anti-Germinal Center Expressed Transcript 2 (GCET2) Antikörper

Mouse (Murine) Germinal Center Expressed Transcript 2 (GCET2) Interaktionspartner

1. Assays identified a non-consensus binding site for Sp factors near sites of transcriptional initiation. The site binds Spl and Sp3 in nuclear extracts.

Human Germinal Center Expressed Transcript 2 (GCET2) Interaktionspartner

1. Diagnostic Utility of the Germinal Center-associated Markers GCET1, HGAL, and LMO2 in Hematolymphoid Neoplasms.

2. These findings further elucidate the growing and complex role of HGAL in B-cell biology and suggest that membrane-bound and cytoplasmic HGAL protein differently regulates distinct biological processes.

3. HGAL and LMO2 may be useful adjuncts in the identification of follicular lymphoma of the nongastric gastrointestinal tract.

4. the germinal centre protein human germinal centre-associated lymphoma regulates B-cell receptor signalling in B-lymphocytes which, without appropriate control, may lead to B-cell lymphoproliferation.

5. HGAL/GCET2 protein expression may function as a marker for germinal center B-cell type diffuse large B-cell lymphoma.

6. Immunostaining for HGAL was more frequently positive than that for BCL6 and CD10 in follicular lymphomas

7. Data suggest that both HGAL and LMO2 are directly regulated by the transcription repressor PRDM1--overexpression of PRDM1 down-regulates HGAL and LMO2; PRDM1 directly binds to promoters of both HGAL and LMO2 and represses genetic transcription.

8. necessary for germinal center maintenance and confining B-cells to the germinal center microenvironment

9. show that HGAL increases the binding of myosin to F-actin and inhibits the ability of myosin to translocate actin by reducing the maximal velocity of myosin head/actin movement

10. HGAL is sensitive and specific marker for detecting follicular lymphoma in nodal and extranodal sites

11. molecular mechanism underlying the inhibitory effects of germinal center-specific HGAL protein on the motility of GC-derived lymphoma cells

12. Our results show that HGAL and LMO2 are sensitive markers for follicular lymphoma diagnosis.

13. Study confirms and validates findings of a correlation between HGAL expression and outcome in classical HL.

14. results report the cloning of HGAL, a germinal center its expression pattern in normal tissues and hematologic malignancies, its induction by IL4, and the prognostic significance of its expression in predicting survival in diffuse large B-cell lymphoma

15. Results report the cloning of germinal center B-cell expressed transcripts 1 and 2 (GCET1 and 2), and show that both are expressed in follicular lymphoma and diffuse large B-cell lymphoma with germinal center B-cell differentiation

16. The restricted expression and germinal center specificity of HGAL protein suggest that it may have an important role in the diagnosis of specific lymphomas

17. HGAL is involved in negative regulation of lymphocyte migration, thus constraining lymphocytes to the germinal center

18. The correlation of HGAL expression with the germinal center B-cell phenotype demonstrates the role of this marker in the classification of cutaneous large B-cell lymphomas