General Transcription Factor III Proteine (GTF2I)

The protein encoded by GTF2I contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. Zusätzlich bieten wir Ihnen GTF2I Antikörper (116) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
GTF2I 2969 P78347
Ratte GTF2I GTF2I 353256 Q5U2Y1
GTF2I 14886 Q9ESZ8
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Top GTF2I Proteine auf

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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage

GTF2I Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
Mouse (Murine)

Weitere Proteine zu General Transcription Factor III (GTF2I) Interaktionspartnern

Human General Transcription Factor III (GTF2I) Interaktionspartner

  1. we identified largest-ever effect on Asian rheumatoid arthritis across human non-HLA regions at GTF2I by heterogeneity mapping followed by replication studies, and pinpointed a possible causal variant

  2. the frequency of GTF2I mutation is higher in more indolent TETs and correlated with better prognosis.

  3. GTF2I/Gtf2i, its physiologic role in human disorders was relatively unknown until recently. Novel studies show that it is involved in an array of human diseases including neurocognitive disorders, systemic lupus erythematosus (SLE), and cancer.

  4. the results reported here support a model whereby common genetic variation in GTF2I mediates human sociality and anxiety via effects on oxytocin reactivity.

  5. GTF2I mutations common in thymic epithelial tumors are not present/uncommon in hematological malignancies.

  6. a new BRAF (zeige BRAF Proteine) fusion in pilocytic astrocytoma

  7. A common polymorphism in the Williams syndrome gene GTF2I associated with reduced social anxiety predicts decreased threat-related amygdala reactivity, which mediates an association between genotype and increased warmth in women.

  8. We identified rs117026326 on GTF2I with GWAS significance (P = 1.10 x 10(-15)) and rs13079920 on RBMS3 (zeige RBMS3 Proteine) with suggestive significance (P = 2.90 x 10(-5)) associating with Primary Sjogren's syndrome in women.

  9. The authors found that human adenovirus 5 infection or ectopic E4-ORF3 expression leads to SUMOylation of TFII-I that precedes a rapid decline in TFII-I protein levels.

  10. A novel interaction between TFII-I and Mdm2 (zeige MDM2 Proteine) with a negative effect on TFII-I transcriptional activity has been documented.

Mouse (Murine) General Transcription Factor III (GTF2I) Interaktionspartner

  1. The Cre-mediated deletion of exon 3 recapitulates a genetic null phenotype, indicating that the conditional Gtf2i line is a valuable tool for studying TFII-I function during embryonic development

  2. found a highly conserved DNA element, common to a set of genes regulated by TFII-I, and identified and validated novel in vivo neuronal targets of this protein affecting the PI3K and TGFbeta (zeige TGFB1 Proteine) signaling pathways

  3. GTF2IRD2 (zeige GTF2IRD2 Proteine) has evolved as a regulator of GTF2IRD1 and TFII-I; inhibiting their function by direct interaction and sequestration into inactive nuclear zones.

  4. data support the hypothesis that upregulation of TFII-I factors leads to activation of a specific group of developmental genes during mESC differentiation

  5. GTF2I duplication results in separation anxiety in mice and humans

  6. In order to clarify the involvement of GTF2I in neurocognitive function, especially social behavior, we have developed and characterized Gtf2i-deficient mice.

  7. Results suggest that DJ-1 (zeige PARK7 Proteine) together with TFII-I operate in concert to cope with various insults and to sustain pancreatic beta-cell function.

  8. behavioral characterization of heterozygous mice with a deletion of the first 140 amino-acids of TFII-I.

  9. data demonstrate that TFII-I, through a Src (zeige SRC Proteine)-dependent mechanism, reversibly translocates from the cytoplasm to the nucleus, leading to the transcriptional activation of growth-regulated genes

  10. acts as a transcriptional cofactor for the SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 (zeige PIAS2 Proteine)

GTF2I Protein Überblick

Protein Überblick

This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7, 13 and 21.

Genbezeichner und Symbole assoziert mit GTF2I

  • general transcription factor IIi (GTF2I)
  • general transcription factor II I (Gtf2i)
  • general transcription factor IIi (gtf2i)
  • general transcription factor IIi (Gtf2i)
  • general transcription factor IIi S homeolog (gtf2i.S)
  • 6030441I21Rik Protein
  • bap-135 Protein
  • bap135 Protein
  • btkap1 Protein
  • diws Protein
  • gtf2i Protein
  • gtf2i.L Protein
  • Gtf2ird1 Protein
  • gtfii-i Protein
  • ib291 Protein
  • spin Protein
  • tfii-i Protein
  • wbs Protein
  • wbscr6 Protein

Bezeichner auf Proteinebene für GTF2I

BTK-associated protein, 135kD , Bruton tyrosine kinase-associated protein 135 , SRF-Phox1-interacting protein , Williams-Beuren syndrome chromosome region 6 , general transcription factor II-I , GTFII-I , TFII-I , BTK-associated protein 135 , general transcription factor II, i , general transcription factor IIi L homeolog , general transcription factor IIi S homeolog

2969 Homo sapiens
353256 Rattus norvegicus
14886 Mus musculus
534669 Bos taurus
549986 Xenopus (Silurana) tropicalis
417486 Gallus gallus
479714 Canis lupus familiaris
100724513 Cavia porcellus
443780 Xenopus laevis
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