Weitere Produktkategorien zu GTF2A1 ELISA Kit
Weitere ELISA Kits für GTF2A1 Interaktionspartner
Mouse (Murine) General Transcription Factor IIA, 1, 19/37kDa (GTF2A1) Interaktionspartner
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TFIIA is the principal TASP1 substrate that orchestrates craniofacial morphogenesis.
Human General Transcription Factor IIA, 1, 19/37kDa (GTF2A1) Interaktionspartner
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De novo produced TFIIA is rapidly confined to the cytoplasm via an evolutionary conserved nuclear export signal (NES, amino acids 21VINDVRDIFL30), interacting with the nuclear export receptor Exportin-1/chromosomal region maintenance 1 (Crm1).
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Proteolytic processing of TFIIA by Taspase1 was found to mask evolutionary conserved nuclear export signal, thereby promoting nuclear localization and transcriptional activation of TFIIA target genes, such as CDKN2A.
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In a cohort of youth at risk for bipolar disorder, pathway analysis showed an enrichment of the glucocorticoid receptor (GR) pathway with the genes MED1, HSPA1L, GTF2A1 and TAF15, which might underlie the previously reported role of stress response in the risk for bipolar disorder in vulnerable populations.
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Data suggest that many TATA-box-containing promoters contain a TFIIA recognition element (IIARE) that activates transcription by increasing the recruitment of RNA polymerase II, TFIIA (TF2A1/TF2A2 subunits), TAF4, and P300. (TAF4 = TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1; P300 = E1A binding protein p300)
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The interaction of TBP-like protein with TFIIA is essential to suppress proteasome-dependent turnover of TBP-like protein
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Our results provide first evidence that Taspase1 processing affects TFIIA regulation of TFIID and suggest that Taspase1 processing of TFIIA is required to establish INR-selective core promoter activity in the presence of NC2.
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spatial positioning of the DNA-bound activation domain is important for efficient activation, possibly by maximizing its interactions with the transcriptional machinery including the TBP-TFIIA-TFIIB-promoter quaternary complex
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Results present the X-ray structures of human and yeast TATA box-binding protein /transcription factor IIA/DNA complexes at 2.1A and 1.9A resolution, respectively
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transcription factor IIA may regulate the intracellular molecular state and the function of TATA-binding protein-like protein (TLP) through its property of binding to TLP
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Transfected taspase 1 enhances cleavage of TFIIA, and RNA interference knockdown of endogenous taspase 1 diminishes cleavage of TFIIA in vivo.
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TFIIA induces a conformational change within the TBP/TATA complex that enhances its stability under both in vitro and physiological salt conditions.
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GTF2A1 alone, or GTF2A1 plus HAAO are excellent candidate biomarkers for detecting Ovarian cancer
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V96F substitution of a deamidated human GTF2A1 (TFIIA) peptide promotes T-cell activation in an in vitro model of Celiac disease inflammation.
GTF2A1 Antigen-Profil
Beschreibung des Gens
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A\; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993
Genbezeichner und Symbole assoziert mit GTF2A1
- general transcription factor IIA subunit 1 (GTF2A1) Antikörper
- general transcription factor IIA 1 L homeolog (gtf2a1.L) Antikörper
- general transcription factor IIA, 1 (gtf2a1) Antikörper
- general transcription factor IIA 1 (gtf2a1) Antikörper
- general transcription factor IIA 1 S homeolog (gtf2a1.S) Antikörper
- general transcription factor II A, 1 (Gtf2a1) Antikörper
- general transcription factor 2A subunit 1 (Gtf2a1) Antikörper
- 6330549H03Rik Antikörper
- AA536742 Antikörper
- AA959775 Antikörper
- AW060250 Antikörper
- fc15h02 Antikörper
- fj36b10 Antikörper
- GTF2A1 Antikörper
- Tf2a Antikörper
- TF2A1 Antikörper
- TFIIA Antikörper
- TFIIA-42 Antikörper
- Tfiia1 Antikörper
- TfIIAa/b Antikörper
- tfiiaa/b-1 Antikörper
- tfiiaa/b-2 Antikörper
- TFIIAL Antikörper
- wu:fc15h02 Antikörper
- wu:fj36b10 Antikörper
- zgc:55847 Antikörper
Bezeichner auf Proteinebene für GTF2A1
general transcription facter IIA subunit 1 variant 1 , transcription initiation factor IIA subunit 1 , transcription factor IIA large subunit-2 , general transcription factor IIA, 1, 19/37kDa , TFIIA alpha, p55 , transcription factor IIA large subunit-1 , TFIIA alpha/beta , general transcription factor IIA subunit 1 , general transcription factor IIa, 1 (37kD and 19kD subunits) , TFIIA large subunit , general transcription factor 2a, 1 , glucose regulated protein, 58kD pseudogene , transcription initiation factor TFIIA 42 kDa subunit
GENE ID | SPEZIES |
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423389 | Gallus gallus |
399209 | Xenopus laevis |
323974 | Danio rerio |
467523 | Pan troglodytes |
549662 | Xenopus (Silurana) tropicalis |
613006 | Canis lupus familiaris |
708130 | Macaca mulatta |
785612 | Bos taurus |
398704 | Xenopus laevis |
100059967 | Equus caballus |
100568291 | Ovis aries |
100580580 | Nomascus leucogenys |
83602 | Mus musculus |
83830 | Rattus norvegicus |
2957 | Homo sapiens |
100172100 | Pongo abelii |
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