anti-Gasdermin B (GSDMB) Antikörper

Human Gasdermin B (GSDMB) Interaktionspartner

1. These studies demonstrate that GSDMB, a gene highly linked to asthma but whose function in asthma is previously unknown, regulates AHR (zeige AHR Antikörper) and airway remodeling without airway inflammation through a previously unrecognized pathway in which GSDMB induces 5-LO (zeige ALOX5 Antikörper) to induce TGF-beta1 (zeige TGFB1 Antikörper) in bronchial epithelium.

2. Full-length GSDMB and its N-terminal domain bind to phosphoinositides or sulfatide, but not cardiolipin. The GSDMB N-terminal domain binds liposomes containing sulfatide, suggesting a role in sulfatide transport. A loop with SNP AAs (zeige FGD1 Antikörper) from controls (Gly299:Pro306) shows high conformational flexibility, but one with AAs (zeige FGD1 Antikörper) (Arg299:Ser306) from people at risk for IBD and asthma is less so and has higher positive surface charge.

3. Data identifies the ERBB2 (zeige ERBB2 Antikörper) co-amplified and co-expressed gene GSDMB as a critical determinant of poor prognosis and therapeutic response in HER2 (zeige ERBB2 Antikörper)-positive breast cancer.

4. Chromosome 17q21 genes ORMDL3 (zeige ORMDL3 Antikörper) and GSDMB are linked to asthma and other immune diseases. (Review)

5. The rs8067378 SNP variants may increase the expression of GSDMB and the risk of the development and progression of cervical SCC (zeige CYP11A1 Antikörper).

6. GSDMB levels are significantly modulated by NMD. Importantly, both AS isoforms and the identified ecircRNA were significantly dysregulated in peripheral blood mononuclear cells of relapsing-remitting MS patients compared to controls.

7. We found strong associations among GSDMB polymorphisms and the presence of AERD and FEV1 in Korean patients with asthma. Our findings indicated that genetic variations of GSDMB may be associated with the development of AERD and aspirin-induced bronchospasm.

8. we investigated the association between GSDMA (zeige GSDMA Antikörper) and GSDMB variants and the incidence of adult and childhood asthma among Jordanians.An association between the GSDMB T/C single nucleotide polymorphism (SNP) genotype and the incidence of childhood asthma was found

9. Based on our results and published findings on GSDMA, GSDMB, LRRC3C, and related proteins, we propose that this locus in part affects IBD susceptibility via effects on apoptosis and cell proliferation

10. GSDMB variants have been shown to be associated with Asthma in children with Rhinovirus infections -induced wheezing illnesses.