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Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Zusätzlich bieten wir Ihnen G Protein-Coupled Receptor 12 Kits (6) und G Protein-Coupled Receptor 12 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Since we have demonstrated that CBD is an inverse agonist for GPR12, this provides novel mechanism of action for CBD, and an initial chemical scaffold upon which highly potent and efficacious agents acting on GPR12 may be developed with the ultimate goal of blocking cancer metastasis.
GPR12 may play a role in cell proliferation and survival
control of gene expression in vascular endothelial cells in the presence of fluid shear stress and classifies it as a sphingosine 1-phosphate receptor
Studying metabolic and emotionality parameters in Gpr12 mutant mice did not reveal a major phenotypic impact of the gene mutation.
the cAMP levels required for maintaining meiotic arrest in mouse and rat oocytes are dependent on the expression of Gpr3 and/or Gpr12
GPCR12 is considered important for the energy balance since GPCR12 KO mice develop obesity and have lower energy expenditure.
Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.
G-protein coupled receptor 12