anti-G Protein Pathway Suppressor 2 (GPS2) Antikörper

GPS2 encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. Zusätzlich bieten wir Ihnen GPS2 Proteine (4) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
GPS2 2874 Q13227
GPS2 56310  
GPS2 497941  
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Top anti-GPS2 Antikörper auf antikoerper-online.de

Showing 10 out of 55 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from RAW264.7 cells, using GPS2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert ELISA, WB 100 μL Verfügbar
$363.46
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, WB ABIN6275133 staining Hela by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL 11 bis 12 Tage
$390.77
Details
Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of PC-3 cells, using GPS2 antibody. Western blot analysis of extracts of various cell lines, using GPS2 antibody (ABIN1872875) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s. 100 μL 11 bis 13 Tage
$366.77
Details
Human Kaninchen Unkonjugiert IP, WB Western blot analysis of extracts of various cell lines, using GPS2 antibody (ABIN5972076) at 1:3000 dilution. Immunoprecipitation analysis of 150 μg extracts of HeLa cells using 3 μg GPS2 antibody (ABIN5972076). Western blot was performed from the immunoprecipitate using GPS2 antibody (ABIN5972076) at a dilition of 1/1000. 100 μL 11 bis 16 Tage
$426.40
Details
Human Maus Unkonjugiert ELISA, WB Detection limit for recombinant GST tagged GPS2 is approximately 0.3ng/ml as a capture antibody. Western Blot analysis of GPS2 expression in transfected 293T cell line by GPS2 monoclonal antibody (M01), clone 3C4.Lane 1: GPS2 transfected lysate (Predicted MW: 36.7 KDa).Lane 2: Non-transfected lysate. 100 μg 11 bis 12 Tage
$364.00
Details
Human Kaninchen Unkonjugiert WB Western Blot analysis of GPS2 expression in transfected 293T cell line by GPS2 MaxPab polyclonal antibody.Lane 1: GPS2 transfected lysate(36.70 KDa).Lane 2: Non-transfected lysate. 100 μg 11 bis 12 Tage
$350.67
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Mouse testis lysates probed with GPS2 Polyclonal Antibody, Unconjugated  at 1:300 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:10000 for 60 min at 37˚C. 100 μL 14 bis 21 Tage
$317.90
Details
Human Kaninchen Unkonjugiert WB   200 μL 13 bis 14 Tage
$487.50
Details

Am meisten referenzierte anti-GPS2 Antikörper

  1. Human Monoclonal GPS2 Primary Antibody für ELISA, WB - ABIN561119 : Sanyal, Båvner, Haroniti, Nilsson, Lundåsen, Rehnmark, Witt, Einarsson, Talianidis, Gustafsson, Treuter: Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)

Weitere Antikörper gegen GPS2 Interaktionspartner

Human G Protein Pathway Suppressor 2 (GPS2) Interaktionspartner

  1. Because GPS2 expression is down-regulated in some humans with obese and type 2 diabetes, the macrophage GPS-2/ABC-A1 pathway could be altered and contribute to atherogenesis

  2. GPS2 enhances BK channel activity and its protein expression by reducing ERK1/2 signaling-mediated degradation of the channel.

  3. These findings, together, reveal an additional layer of regulation of mitochondrial gene transcription, uncover a direct mitochondria-nuclear communication pathway, and indicate that GPS2 retrograde signaling is a key component of the mitochondrial stress response in mammals.

  4. The study of adipose tissue from humans with and without obesity revealed correlations between reduced GPS2 expression in macrophages, elevated systemic and adipose tissue inflammation, and diabetic status.

  5. our studies identify GPS2 functions as a tumor suppressor in LPS and its downregulation is correlated to prognosis of LPS.

  6. Posttranslational modification of GPS2 by SUMOylation may serve as a key factor that regulates the function of GPS2 in vivo.

  7. regulation of GPS2 by posttranslational modifications provides an effective strategy for modulating its molecular function within the nuclear compartment.

  8. Chromosomal translocation in a pediatric undifferentiated spindle cell sarcoma have characterized this alteration to show rearrangement of the MLL4 and GPS2 genes, resulting in fusion gene MLL4-GPS2, the expression of which promotes independent growth.

  9. GPS2 is required for the association of viral NS5A with VAP-A and hepatitis C virus replication.

  10. expression of the transcriptional corepressor complex subunits GPS2 and SMRT was significantly reduced in obese adipose tissue, inversely correlated to inflammatory status

  11. Results show for the first time that GPS-2 is differentially methylated at a site that lacks known methylation motifs and that the methylation state is detected by the immune system

  12. metabolically important coregulator GPS2 functions as a hitherto unrecognized transrepression mediator of interactions between SUMOylated nuclear receptors and the N-CoR corepressor complex

  13. Results show that the N-CoR-HDAC3 complex inhibits JNK activation through the associated GPS2 subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP-1 function.

  14. the GPS2 might function in concert with hMSH4-hMSH5 during the process of homologous recombination.

  15. Direct interactions of GPS2 with hnf4alpha and farnesoid x receptor indicate alternative coregulator recruitment strategies to cause differential transcriptional outcomes in governing bile acid biosynthesis.

  16. GPS2 interacts with RFX4_v3 to modulate transactivation of genes involved in brain morphogenesis, including Cx3Cl1

  17. Data describe the requirement of GPS2 for ABCG1 gene transcription and cholesterol efflux from macrophages, and implicate GPS2 in facilitating LXRalpha/beta recruitment to an ABCG1-specific promoter/enhancer unit upon ligand activation.

  18. G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation.

Mouse (Murine) G Protein Pathway Suppressor 2 (GPS2) Interaktionspartner

  1. GPS2 enhances BK channel activity and its protein expression by reducing ERK1/2 signaling-mediated degradation of the channel.

  2. Study in GPS2 knockout mice reveals that GPS2 in hepatocytes functionally cooperates with NCOR but not with SMRT to repress PPAR-alpha. These data collectively suggest that GPS2 promotes the progression of fatty liver disease as an epigenome modifier and PPAR-alpha-selective corepressor in hepatocytes.

  3. These findings, together, reveal an additional layer of regulation of mitochondrial gene transcription, uncover a direct mitochondria-nuclear communication pathway, and indicate that GPS2 retrograde signaling is a key component of the mitochondrial stress response in mammals.

  4. In macrophage-specific Gps2-knockout mice, inappropriate co-repressor complex function caused enhancer activation, pro-inflammatory gene expression and hypersensitivity toward metabolic-stress signals. By contrast, transplantation of GPS2-overexpressing bone marrow into two mouse models of obesity (ob/ob and diet-induced obesity) reduced inflammation and improved insulin sensitivity.

  5. GPS2 is required for restricting the activation of TLR and BCR signaling pathways and the AKT/FOXO1 pathway in immune cells based on direct inhibition of Ubc13 enzymatic activity

  6. GPS2 stabilizes KDM4A on target promoters by inhibiting Ubc13/RNF8 ubiquitination.

  7. GPS2 binds to active PPARgamma, facilitates its repression by NCoR, and is required for the optimal NCoR corepressor function for PPARgamma.

  8. GPS2 as a molecular guardian required for precise control of inflammatory responses involved in immunity and homeostasis.

  9. metabolically important coregulator GPS2 functions as a hitherto unrecognized transrepression mediator of interactions between SUMOylated nuclear receptors and the N-CoR corepressor complex

GPS2 Antigen-Profil

Protein Überblick

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.

Genbezeichner und Symbole assoziert mit GPS2

  • G protein pathway suppressor 2 (gps2) Antikörper
  • G protein pathway suppressor 2 L homeolog (gps2.L) Antikörper
  • G protein pathway suppressor 2 (GPS2) Antikörper
  • G protein pathway suppressor 2 (Gps2) Antikörper
  • AI505953 Antikörper
  • AMF-1 Antikörper
  • GPS2 Antikörper
  • MGC63588 Antikörper
  • MGC68832 Antikörper
  • MGC133909 Antikörper
  • zgc:63588 Antikörper

Bezeichner auf Proteinebene für GPS2

G protein pathway suppressor 2 , G-protein pathway suppressor 2 , GPS-2

GENE ID SPEZIES
379878 Xenopus laevis
393948 Danio rerio
403370 Xenopus laevis
455229 Pan troglodytes
518494 Bos taurus
100135707 Xenopus (Silurana) tropicalis
100529005 Ictalurus punctatus
2874 Homo sapiens
56310 Mus musculus
497941 Rattus norvegicus
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