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GPS2 encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades.
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Human Monoclonal GPS2 Primary Antibody für ELISA, WB - ABIN561119
Sanyal, Båvner, Haroniti, Nilsson, Lundåsen, Rehnmark, Witt, Einarsson, Talianidis, Gustafsson, Treuter: Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis. in Proceedings of the National Academy of Sciences of the United States of America 2007
The study of adipose tissue from humans with and without obesity revealed correlations between reduced GPS2 expression in macrophages, elevated systemic and adipose tissue inflammation, and diabetic status.
our studies identify GPS2 functions as a tumor suppressor in LPS (zeige IRF6 Antikörper) and its downregulation is correlated to prognosis of LPS (zeige IRF6 Antikörper).
Posttranslational modification of GPS2 by SUMOylation may serve as a key factor that regulates the function of GPS2 in vivo.
regulation of GPS2 by posttranslational modifications provides an effective strategy for modulating its molecular function within the nuclear compartment.
Chromosomal translocation in a pediatric undifferentiated spindle cell sarcoma have characterized this alteration to show rearrangement of the MLL4 (zeige MLL2 Antikörper) and GPS2 genes, resulting in fusion gene MLL4 (zeige MLL2 Antikörper)-GPS2, the expression of which promotes independent growth.
GPS2 is required for the association of viral NS5A with VAP-A (zeige VAPA Antikörper) and hepatitis C virus replication.
expression of the transcriptional corepressor complex subunits GPS2 and SMRT was significantly reduced in obese adipose tissue, inversely correlated to inflammatory status
Results show for the first time that GPS-2 is differentially methylated at a site that lacks known methylation motifs and that the methylation state is detected by the immune system
metabolically important coregulator GPS2 functions as a hitherto unrecognized transrepression mediator of interactions between SUMOylated nuclear receptors and the N-CoR (zeige NCOR1 Antikörper) corepressor complex
Results show that the N-CoR (zeige NCOR1 Antikörper)-HDAC3 (zeige HDAC3 Antikörper) complex inhibits JNK (zeige MAPK8 Antikörper) activation through the associated GPS2 subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP-1 (zeige FOSB Antikörper) function.
In macrophage-specific Gps2-knockout mice, inappropriate co-repressor complex function caused enhancer activation, pro-inflammatory gene expression and hypersensitivity toward metabolic-stress signals. By contrast, transplantation of GPS2-overexpressing bone marrow into two mouse models of obesity (ob/ob and diet-induced obesity) reduced inflammation and improved insulin (zeige INS Antikörper) sensitivity.
GPS2 is required for restricting the activation of TLR and BCR (zeige BCR Antikörper) signaling pathways and the AKT (zeige AKT1 Antikörper)/FOXO1 (zeige FOXO1 Antikörper) pathway in immune cells based on direct inhibition of Ubc13 (zeige UBE2N Antikörper) enzymatic activity
GPS2 stabilizes KDM4A (zeige KDM4A Antikörper) on target promoters by inhibiting Ubc13 (zeige UBE2N Antikörper)/RNF8 (zeige RNF8 Antikörper) ubiquitination.
GPS2 binds to active PPARgamma (zeige PPARG Antikörper), facilitates its repression by NCoR (zeige NCOR1 Antikörper), and is required for the optimal NCoR (zeige NCOR1 Antikörper) corepressor function for PPARgamma (zeige PPARG Antikörper).
GPS2 as a molecular guardian required for precise control of inflammatory responses involved in immunity and homeostasis.
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.
G protein pathway suppressor 2
, G-protein pathway suppressor 2