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FUT8 encodes an enzyme belonging to the family of fucosyltransferases. Zusätzlich bieten wir Ihnen FUT8 Antikörper (67) und FUT8 Kits (19) und viele weitere Produktgruppen zu diesem Protein an.
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our study provides the first direct evidence for the involvement of Fut8 in liver regeneration.
Loss of core fucosylation on AMPARs enhanced their heteromerization, which increase sensitivity for postsynaptic depolarization and persistently activate N-methyl-d-aspartate receptors as well as Ca(2 (zeige CA2 Proteine)+) influx and CaMKII (zeige CAMK2G Proteine) and then impair LTP (zeige SCP2 Proteine).
findings define FUT8 as a novel factor for hemoglobin production and demonstrate that core fucosylation plays an important role in erythroid differentiation
FUT8 is up-regulated during epithelial-mesenchymal transition (EMT (zeige ITK Proteine)), a critical process for malignant transformation of tumor, via the transactivation of beta-catenin (zeige CTNNB1 Proteine)/lymphoid enhancer-binding factor-1 (LEF-1 (zeige LEF1 Proteine)).
These data suggest that reduced Fut8 activity is associated with the progression of COPD (zeige ARCN1 Proteine) and serum Fut8 activity is a non-invasive predictive biomarker candidate for progression and exacerbation of COPD (zeige ARCN1 Proteine).
Increased expression and activity of alpha-1,6-fucosyltransferase (FUT8) in the liver are strongly linked to the age-related changes in protein glycosylation.
epidermal growth factor (zeige EGF Proteine) induced phosphorylation levels of the EGF receptor (EGFR (zeige EGFR Proteine)) were substantially blocked in Fut8-/- cells. Consistent with this, EGFR (zeige EGFR Proteine)-mediated JNK (zeige MAPK8 Proteine) or ERK (zeige EPHB2 Proteine) activation was significantly suppressed in Fut8-/- cells.
EGFR (zeige EGFR Proteine)-trypsin-PAR-2 (zeige F2RL1 Proteine) pathway is suppressed in Fut8-/- mice.
Reduced alpha4 1 integrin/vascular cell adhesion molecule 1 (zeige VCAM1 Proteine) interactions lead to impaired pre-B cell repopulation in alpha 1,6-fucosyltransferase deficient mice
Vascular endothelial growth factor receptor-2 (VEGFR-2 (zeige KDR Proteine)) expression was significantly suppressed in Fut8(-/-) mice, suggesting that Fut8 was required for VEGFR-2 (zeige KDR Proteine) expression.
This study thus provides insights into the interplay among FUT8, N-acetylglucosaminyltransferase (zeige GCNT2 Proteine) , and GnT-V (zeige MGAT5 Proteine) in N-linked glycosylation during the assembly of glycoproteins.
Our results reveal a positive feedback mechanism of FUT8-mediated receptor core fucosylation that promotes TGF-b signaling and EMT (zeige ITK Proteine), thus stimulating breast cancer cell invasion and metastasis.
FUT8 is regulated by microRNAs and has a role in hepatocellular carcinoma progression
the possibility that the higher fucose levels on cell surface glycans of aggressive anaplastic thyroid cancer samples (ATCs (zeige CHST14 Proteine)), compared to those of less aggressive papillary thyroid cancer samples(PTC (zeige F9 Proteine)), may be at least in part responsible for the more aggressive and metastatic phenotype of ATCs (zeige CHST14 Proteine) compared to PTCs, as the expression levels of FUCA1 (zeige FUCA1 Proteine) and FUT8 were inversely related in these two types of cancers.
We observed a strong correlation between EVI1 (zeige MECOM Proteine) and alpha1, 6-fucosyltransferase (FUT8) in the chronic phase of the disease and both of them were found to be up-regulated with the progression of the disease.
results suggest that an appropriate polypeptide context or other adequate structural elements in the acceptor substrate could facilitate the core fucosylation by FUT8
FUT8 is a driver of melanoma metastasis which, when silenced, suppresses invasion and tumor dissemination.
The production of the homogeneous core-fucosylated Man5GlcNAc2 glycoform of EPO (zeige EPO Proteine) in the FUT8-overexpressed HEK293S GnT I (zeige MGAT1 Proteine)(-/-) cell line represents the first example of production of fully core-fucosylated high-mannose glycoforms.
Expression of FUT8 can stratify breast cancer tissue and may be considered a prognostic marker for breast cancer patients
MiR (zeige MLXIP Proteine)-198 was shown to target the 3'UTR of FUT8 directly to downregulate FUT8 expression.
This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants.
, GDP-fucose--glycoprotein fucosyltransferase
, alpha (1,6) fucosyltransferase
, glycoprotein 6-alpha-L-fucosyltransferase
, Glycoprotein 6-alpha-L-fucosyltransferase
, alpha 1,6 fucosyltransferase