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FLI1 encodes a transcription factor containing an ETS DNA-binding domain. Zusätzlich bieten wir Ihnen Friend Leukemia Virus Integration 1 Antikörper (158) und Friend Leukemia Virus Integration 1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
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CXCL6 expression is upregulated by Fli1 deficiency in fibroblasts and endothelial cells, potentially contributing to the development of fibrosis and vasculopathy in the skin, lung, and heart of systemic sclerosis.
This is the first report presenting CD13 (zeige ANPEP Proteine) and FLI1 as important mediators of resistance to BRAF (zeige BRAF Proteine) inhibition with potential as drug targets in BRAF (zeige BRAF Proteine) inhibitors refractory melanoma.
This study uncovers FLI1 as an important driving factor that promotes tumor growth in SCLC through the miR-17-92 pathway. FLI1 may serve as an attractive target for therapeutic intervention of SCLC.
identification of two novel FLI1 variants (c.1010G>A and c.1033A>G) responsible for macrothrombocytopenia; study provides new insights into the phenotype, pathophysiology and diagnosis of FLI1 variant-associated thrombocytopenia
miR (zeige MLXIP Proteine)-145 acts as a tumor suppressor by directly reducing expression of FLI-1, and the miR (zeige MLXIP Proteine)-145/FLI-1 pathway is important for tumor progression in osteosarcoma
this paper provides a mechanistic insight into the regulation of angiogenesis by TLRs and confirm a central role of Fli1 in regulating vascular homeostasis.
Recent advances in biologic and genomic understanding of these two cancers has expanded the potential for therapeutic advancement and prevention. In Ewing sarcoma, directed focus on inhibition of EWSR1 (zeige EWSR1 Proteine)-FLI1 and its effectors has produced promising results.
Fusion of short fragments of EWSR1 (zeige EWSR1 Proteine) to FLI1 is sufficient to recapitulate BAF (zeige BANF1 Proteine) complex retargeting and EWS (zeige EWSR1 Proteine)-FLI1 activities; studies thus demonstrate that the physical properties of prion (zeige PRNP Proteine)-like domains can retarget critical chromatin regulatory complexes to establish and maintain oncogenic gene expression programs.
In American cutaneous leishmaniasis caused by Leishmania braziliensis infection, MMP1 (zeige MMP1 Proteine) is regulated by factors other than FLI1, and the influence of IL-6 (zeige IL6 Proteine) on MMP1 (zeige MMP1 Proteine) was independent of its effect on FLI1.
epithelial Fli1 deficiency might be involved in the systemic autoimmunity and selective organ fibrosis in systemic sclerosis (SSc (zeige CYP11A1 Proteine)).
Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 (zeige NFE2 Proteine) and either RUNX1 (zeige RUNX1 Proteine), FLI1 or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.
loss of ERG (zeige ERG Proteine) and FLI1 might contribute to the pathogenesis of vascular lung complications through the induction of inflammation.
These results provide the first evidences that Fli-1 positively regulates LPS (zeige TLR4 Proteine)-induced IL-27 (zeige IL27 Proteine) production in macrophages
protective against nephritis MRL/lpr (zeige FAS Proteine) mice
Fli1 is epigenetically suppressed and is a potential predisposing factor in the pathogenesis of systemic sclerosis. (Review)
The short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 (zeige ETS1 Proteine) and FLI1.
Simultaneous downregulation of KLF5 (zeige KLF5 Proteine) and Fli1 is a key feature underlying systemic sclerosis.
bosentan...increased DNA binding of Fli1 and the suppression of type I collagen expression in systemic sclerosis fibroblasts
FLI1 and GATA2 (zeige GATA2 Proteine) are upstream regulators of SMAD1 (zeige SMAD1 Proteine) and SMAD5 (zeige SMAD5 Proteine) expression in endothelial cells.
These results demonstrate that Fli-1 is a novel regulator of the proinflammatory chemokine (zeige CCL1 Proteine) MCP-1 (zeige CPT1B Proteine).
mesodermal Wnt3a (zeige WNT3A Proteine)-mediated signaling via the transcription factor Lef1 (zeige LEF1 Proteine) positively regulates EC specification (defined by kdrl expression) at the expense of primitive erythrocyte specification (defined by gata1 (zeige GATA1 Proteine) expression) in zebrafish embryos.
Fli+ etsrp (zeige ETV2 Proteine)+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
These results showed that young thrombocytes have higher GATA1 (zeige GATA1 Proteine) promoter activity, while mature thrombocytes have more fli1 gene promoter transcription.
fli1, and etsrp (zeige ETV2 Proteine), demonstrated that erg (zeige KCNH2 Proteine) and fli1 act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin (zeige CDH5 Proteine)
Interaction between EWSR1 (zeige EWSR1 Proteine)/FLI1 and EWSR1 (zeige EWSR1 Proteine) in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11\;22)(q24\;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4\;11)(q21\;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
Ewing sarcoma breakpoint region 2
, Friend leukemia integration 1 transcription factor
, Friend leukemia virus integration 1
, proto-oncogene Fli-1
, transcription factor ERGB
, fli-1 proto-oncogene
, friend leukemia integration 1 transcription factor-like
, Friend leukemia integration 1 transcription factor-like
, retroviral integration site protein Fli-1
, retroviral integration site protein Fli-1 homolog