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FLI1 encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. Zusätzlich bieten wir Ihnen Friend Leukemia Virus Integration 1 Proteine (8) und Friend Leukemia Virus Integration 1 Kits (7) und viele weitere Produktgruppen zu diesem Protein an.
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Cow (Bovine) Polyclonal FLI1 Primary Antibody für WB - ABIN2780392
van den Akker, van Dijk, Schmidt, Felida, Beug, Loewenberg, von Lindern: The Btk inhibitor LFM-A13 is a potent inhibitor of Jak2 kinase activity. in Biological chemistry 2004
Show all 3 Pubmed References
These results indicate that Fli1 deficiency promotes migration, proliferation and cell survival, while abating tube formation of endothelial cells, suggesting that Fli1 deficiency is potentially attributable to the development of both proliferative obliterative vasculopathy (occlusion of arterioles and small arteries) and destructive vasculopathy (loss of small vessels) characteristic of SSc (zeige CYP11A1 Antikörper) vasculopathy.
Fli1 functioned as an oncogene (zeige RAB1A Antikörper) in HCC (zeige FAM126A Antikörper) carcinogenesis and it exerted its promoting metastatic effect primarily by modulating the matrix metalloproteinase (MMP)2 (zeige MMP2 Antikörper) signaling pathway.
Decreased serum LIF levels may be associated with vasculopathy in systemic sclerosis (SSc) and that Fli1 deficiency may contribute to the inhibition of LIF-dependent biological effects on SSc endothelial cells by suppressing the expression of LIF, LIF receptor, and gp130.
Studies demonstrate that the translocation-derived fusion protein EF (EWS (zeige EWSR1 Antikörper)-FLI1) misregulates numerous genes involved in metabolism suggesting that EF is a master regulator of metabolic reprogramming in Ewing sarcoma, diverting metabolites toward biosynthesis.
The gene that was most reproducibly up-regulated by EWS (zeige EWSR1 Antikörper)/FLI (zeige FLII Antikörper) was NR0B1 (zeige NR0B1 Antikörper).
The mouse (Fli1) and human Fli1 genes are similarly regulated by Ets (zeige ETS1 Antikörper) factors in T cells.
In contrast, expression of Spi1 (zeige SPI1 Antikörper)/PU.1 in a Fli1 producing erythroleukemia cell line in which fli1 is activated, resulted in increased proliferation through activation of growth promoting proteins MAPK (zeige MAPK1 Antikörper), AKT (zeige AKT1 Antikörper), cMYC (zeige MYC Antikörper) and JAK2 (zeige JAK2 Antikörper)
CXCL6 expression is upregulated by Fli1 deficiency in fibroblasts and endothelial cells, potentially contributing to the development of fibrosis and vasculopathy in the skin, lung, and heart of systemic sclerosis.
This is the first report presenting CD13 (zeige ANPEP Antikörper) and FLI1 as important mediators of resistance to BRAF (zeige BRAF Antikörper) inhibition with potential as drug targets in BRAF (zeige BRAF Antikörper) inhibitors refractory melanoma.
This study uncovers FLI1 as an important driving factor that promotes tumor growth in SCLC through the miR-17-92 pathway. FLI1 may serve as an attractive target for therapeutic intervention of SCLC.
the Fox transcription factor binding motif was frequently observed within EWS (zeige EWSR1 Antikörper)-FLI1 peaks and Foxq1 (zeige FOXQ1 Antikörper) was identified as the cooperative partner that interacts with the EWS (zeige EWSR1 Antikörper) portion of EWS (zeige EWSR1 Antikörper)-FLI1.
Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 (zeige NFE2 Antikörper) and either RUNX1 (zeige RUNX1 Antikörper), FLI1 or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.
loss of ERG (zeige ERG Antikörper) and FLI1 might contribute to the pathogenesis of vascular lung complications through the induction of inflammation.
These results provide the first evidences that Fli-1 positively regulates LPS (zeige TLR4 Antikörper)-induced IL-27 (zeige IL27 Antikörper) production in macrophages
protective against nephritis MRL/lpr (zeige FAS Antikörper) mice
Fli1 is epigenetically suppressed and is a potential predisposing factor in the pathogenesis of systemic sclerosis. (Review)
The short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 (zeige ETS1 Antikörper) and FLI1.
Simultaneous downregulation of KLF5 (zeige KLF5 Antikörper) and Fli1 is a key feature underlying systemic sclerosis.
bosentan...increased DNA binding of Fli1 and the suppression of type I collagen expression in systemic sclerosis fibroblasts
mesodermal Wnt3a (zeige WNT3A Antikörper)-mediated signaling via the transcription factor Lef1 (zeige LEF1 Antikörper) positively regulates EC specification (defined by kdrl expression) at the expense of primitive erythrocyte specification (defined by gata1 (zeige GATA1 Antikörper) expression) in zebrafish embryos.
Fli+ etsrp (zeige ETV2 Antikörper)+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
These results showed that young thrombocytes have higher GATA1 (zeige GATA1 Antikörper) promoter activity, while mature thrombocytes have more fli1 gene promoter transcription.
fli1, and etsrp (zeige ETV2 Antikörper), demonstrated that erg (zeige KCNH2 Antikörper) and fli1 act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin (zeige CDH5 Antikörper)
Interaction between EWSR1 (zeige EWSR1 Antikörper)/FLI1 and EWSR1 (zeige EWSR1 Antikörper) in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11\;22)(q24\;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4\;11)(q21\;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
Ewing sarcoma breakpoint region 2
, Friend leukemia integration 1 transcription factor
, Friend leukemia virus integration 1
, proto-oncogene Fli-1
, transcription factor ERGB
, fli-1 proto-oncogene
, friend leukemia integration 1 transcription factor-like
, Friend leukemia integration 1 transcription factor-like
, retroviral integration site protein Fli-1
, retroviral integration site protein Fli-1 homolog