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The protein encoded by FNBP1L binds to both CDC42 and N-WASP.
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This suggests that TOCA1 binding to Cdc42 is an early step in the Cdc42-dependent pathways that govern actin dynamics, and the differential binding affinities of the effectors facilitate a handover from TOCA1 to N-WASP, which can then drive recruitment of the actin-modifying machinery.
Loss of p53 tumor suppressor (zeige TP53 ELISA Kits) function in breast cancers leads to upregulation of Toca-1, and results in enhanced risk of developing metastatic disease.
GWAS results show that the aggregate effects of common SNPs explain 22-46% of phenotypic variation in childhood intelligence in the three largest cohorts; FNBP1L was also significantly associated with childhood intelligence
findings suggest that Toca-1 functions at an early step in the dissemination of metastatic breast tumor cells; taken together, results identify Toca-1 as a proinvasive protein in breast adenocarcinoma
Toca-1 knockdown cells also display a significant defect in EGF (zeige EGF ELISA Kits)-induced motility and invasiveness.
Cdc42 may influence endocytic membrane trafficking by regulating the formation and activity of the Toca-1/N-WASP complex.
Toca-1 promotes actin nucleation by activating the N-WASP-WIP/CR16 complex, the predominant form of N-WASP in cells.
a vesicle trafficking regulator Toca-1 regulates different aspects of neuronal morphology from N-WASP
We show that actin tail initiation by S. flexneri requires Toca-1 for the conversion of N-WASP from a closed inactive conformation to an open active one.
the Toca-1-N-WASP complex can link filopodial formation to endocytosis
Toca-1(knockdown) cells have defects in formation of myotubes probably due to reduced activity of actin cytoskeleton regulators such as N-WASP.
The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.
formin-binding protein 1-like
, transducer of Cdc42-dependent actin assembly 1
, transducer of Cdc42-dependent actin assembly protein 1
, Cdc42 effector
, formin binding protein 1-like
, transducer of Cdc42-dependent actin assembly-1
, Transducer of Cdc42-dependent actin assembly protein 1