Fibrinogen alpha Chain (FGA) ELISA Kits

Human Fibrinogen alpha Chain (FGA) Interaktionspartner

1. ERp5 triggers fibrinogen dissociation from aIIbb3 integrin.

2. Certain core genes, including COL12A1, glutathione Stransferase alpha3 (GSTA3), fibrinogen alpha chain (FGA) and fibrinogen gamma chain (FGG), were the first reported to be associated with Gastric Cancer. Survival analysis suggested that these four genes, COL12A1 (P=0.002), GSTA3 (P=3.4x106), FGA (P=0.00075) and FGG (P=1.4x105), were significant poor prognostic factors of gastric cancer.

3. this study shows that hypofibrinogenaemia associated with novel Aalpha126Val-->Asp mutation in the fibrinogen coiled coil

4. All the exons and exon-intron boundaries of fibrinogen genes (FGA, FGB and FGG) were analysed by direct DNA sequencing

5. Taken together, an increased pretreatment plasma fibrinogen level was related to worse survival in digestive system tumors, indicating that it could be a useful prognostic marker in these types of tumors.

6. The risk of early pregnancy loss was significantly higher in women with homozygous or heterozygous FGA: p.Thr331Ala polymorphism than in women with FGA: p.Thr331 (Odds ratio: 8.84, P < .05).

7. Data defined the mutational burden of the fibrinogen FGA, FGB, and FGG genes, and estimated the prevalence of inherited fibrinogen disorders through a systematic analysis of exome/genome data.

8. CD47 expression is decreased on the surface of erythrocytes in obese subjects. These changes in CD47 expression on the erythrocytes surface may be an adaptive response to hyperfibrinogenemia associated with obesity.

9. Fibrinogen A alpha arginine-glycine-aspartate sequence (residues 95-97) is essential for binding to its erythrocyte receptor.

10. Binding of human fibrinogen to MRP enhances Streptococcus suis survival in host blood in a alphaXbeta2 integrin-dependent manner.

11. High fibrinogen level is associated with Type-2 diabetes and diabetic vascular disease.

12. The heterozygous AalphaArg16His and gammaAsp185Asn identified in the study probably underlie the dysfibrinogenemia in this pedigree, with the latter being identified for the first time.

13. A brief history of some key events in the conversion of fibrinogen to fibrin has been reviewed. (Review)

14. Preoperative fibrinogen levels appeared as an independent mortality risk factor in non-metastatic colorectal cancer patients with normal GPS scores

15. evidence that VLITL confers amyloidogenic properties to Aalpha-chain frameshift variants, yielding a previously unknown molecular basis for the pathogenesis of Aalpha-chain amyloidosis

16. We used mass spectrometry of plasma from trauma patients to find that fibrinogen Aalpha-C domain methionine sulfoxide content was selectively-increased in patients with coagulopathy vs. those without coagulopathy. This evidence supports a novel linkage between oxidative stress, coagulopathy, and bleeding after injury

17. Using a quantum chemical approach method, it has been established that mutations in MMP-10 and FGA proteins led to substantial energetic modifications suggesting an impact on their functions and/or stability in the recurrent pregnancy loss patients.

18. this study elucidates a molecular mechanism linking CB1R signaling, ERRgamma expression and fibrinogen gene transcription.

19. Data indicate that repeated measurement after five hours showed a statistical significant difference for the fractional synthesis rate of fibrinogen but not for albumin.

20. Data indicate only the highest concentration of apixaban was capable to significantly reduce thrombus formation, fibrin association and platelet-aggregate formation.

Cow (Bovine) Fibrinogen alpha Chain (FGA) Interaktionspartner

1. two different approaches to tune the fibrillar structure and mechanical properties of fibrin hydrogels, are reported.

2. Full-length bovine alphaC-domain, bAalpha374-568, and its human counterpart, hAalpha392-610, can form ordered oligomers in a similar manner.

3. NMR solution structure of the bovine fibrinogen alphaC-domain fragment, including residues Aalpha374-538, reveals a type-I' beta-hairpin, restricted at the base by a C423-C453 disulfide linkage and a short turn preceding C423.

4. the complete NMR solution structure of the Aalpha406-483 alphaC-domain fragment, provide direct evidence for the intra- and intermolecular interactions between the alphaC-domains, and confirm that these interactions are thermodynamically driven.

Mouse (Murine) Fibrinogen alpha Chain (FGA) Interaktionspartner

1. cellular fibrin uptake was diminished by elimination of CCR2-expressing cells.

2. Mice expressing a mutant form of fibrinogen cannot support fibrin formation exhibit compromised antimicrobial host defense.

3. Data indicate RU-505 as an effective inhibitor of the beta-amyloid (Abeta)-fibrinogen interaction.

4. These results suggest that immunoreactivity of Fg in the kidney, as well as urinary excretion of Fg, serves as a sensitive and early diagnostic translational biomarker for detection of acute kidney injury.

5. Data indicate that FXIIIa-targeted probe signals showed good overlap with immune-fluorescent fibrin staining images.

6. Fbg deficiency was associated with enhanced hepatic expression of the transcription factor early growth response-1.