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FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known. Zusätzlich bieten wir Ihnen FTO Antikörper (143) und FTO Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.
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Studied weight loss in obese patients with Perilipin 4 (PLIN4 (zeige PLIN4 ELISA Kits)), Fat mass and obesity-associated (FTO), and beta- adrenergic receptor 3 (ADRB3 (zeige ADRB3 ELISA Kits)) polymorphisms treated with Garcinia cambogia/Glucomannan. Results suggest weight loss was attenuated in carriers of PLIN4 (zeige PLIN4 ELISA Kits), FTO, ADRB3 (zeige ADRB3 ELISA Kits) polymorphisms.
Fat mass and obesity associated (FTO) was the first gene found to be associated with obesity in three independent genome-wide association studies.
It has been shown, that presence of one mutant allele of rs9939609 (gene FTO) and rs4994 (gene ADRB3 (zeige ADRB3 ELISA Kits)) leads to statistically significant association with obesity.
Food advertisement exposure was associated with greater caloric consumption of a recently advertised food, and this effect was modified by an FTO genotype. Future research is needed to understand the neurological mechanism underlying these associations.
FTO rs9939609 polymorphism is observed to be associated with obesity.
FTO rs9939609 polymorphism in recurrent VTE may differ according to gender.
the first intron of the FTO gene is associated with obesity in humans in a mechanism potentially involving the risk allele (rs1421085)
The age of diabetes was not affect by the tested FTO polymorphisms (rs9939609 , rs1421085, and rs9930506).
Infants carrying the GG genotype of the LEP (zeige LEP ELISA Kits) rs7799039 polymorphism were 2.12 times more likely to be born large for gestational age (LGA (zeige GLS2 ELISA Kits)) than those carrying the GA + AA genotypes. Newborns carrying the TG or GG genotype of the ADIPOQ rs2241766 polymorphism were 1.88 times more likely to be born LGA (zeige GLS2 ELISA Kits) than those carrying the TT genotype. No association was found between the FTO gene polymorphism and newborn weight status.
FTO obesity risk allele is associated with differential neural processing of food images.
This is the first study revealing the presence of a parallel increase in expressions of FTO and HNRNPK (zeige HNRNPK ELISA Kits) proteins. This increase may codictate the metabolic changes occurring in the cell and may attribute a significance to HNRNPK (zeige HNRNPK ELISA Kits) in FTO-associated transformations.
Contextual fear conditioning decreased FTO levels in neurons from the hippocampus.
The involvement of mTOR (zeige FRAP1 ELISA Kits)-PGC-1alpha (zeige PPARGC1A ELISA Kits) pathway in the connection between FTO and muscle differentiation is displayed.
In vivo experiments revealed that Fto(-/-) and Fto(+/-) mice were more susceptible to thiopurine-induced myelosuppression than wild-type mice.
propose that PKCbeta acts to suppress the degradation of FTO protein and reveals the associated role of PKCbeta and FTO in adipogenesis, suggesting a new pathway that affects the development of obesity and metabolic diseases
the results of this study indicate that the effects of FTO-associated SNPs on energy homeostasis are due in part to the effects of these genetic variations on hypothalamic FTO, RPGRIP1L (zeige RPGRIP1L ELISA Kits), and possibly other genes.
FTO may have a deleterious role in hepatic cells during lipotoxic conditions, and up-regulation of FTO may contribute to the increased liver damage in non-alcoholic steatohepatitis
Fto deficiency affects the gene and miR130/miR378 expression involved in brown adipogenesis and browning of white adipose tissue in mice.
Here we show that FTO expression is increased after ureteral obstruction and renal fibrosis.
Taken together, the results suggest that Fto regulates the proliferation and differentiation of 3T3-L1 cells via multiple mechanisms, including PPARgamma (zeige PPARG ELISA Kits) and PI3K/Akt (zeige AKT1 ELISA Kits) signaling.
In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.
In pig, the FTO gene influences back fat depth in the commercial populations.
This study will provide clues for obtaining a better understanding of the porcine FTO gene function.
The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.
The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.
34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.
association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein (zeige CSN2 ELISA Kits) yield
Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.
alpha-ketoglutarate-dependent dioxygenase FTO
, fat mass and obesity-associated protein
, protein fto
, protein fatso
, fat mass and obesity associated protein
, Protein fatso