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The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Zusätzlich bieten wir Ihnen FANCL Kits (4) und FANCL Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal FANCL Primary Antibody für WB - ABIN1881336
Zhang, Zhao, Park, Wang, Dyer, Liu, Klee, McNiven, Tindall, Molina, Fei: FAVL elevation in human tumors disrupts Fanconi anemia pathway signaling and promotes genomic instability and tumor growth. in The Journal of clinical investigation 2010
Show all 5 Pubmed References
Human Polyclonal FANCL Primary Antibody für ELISA, WB - ABIN4310523
García, Fernández, Osorio, Barroso, Fernández, Urioste, Benítez et al.: Mutational analysis of FANCL, FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer ... in Carcinogenesis 2009
Human Polyclonal FANCL Primary Antibody für IHC, IHC (p) - ABIN4310524
Panneerselvam, Pickering, Han, Li, Zheng, Zhang, Zhang, Fei: Basal level of FANCD2 monoubiquitination is required for the maintenance of a sufficient number of licensed-replication origins to fire at a normal rate. in Oncotarget 2014
A novel homozygous mutation c.822_823insCTTTCAGG (p.Asp275LeufsX13) in the FANCL gene identified in a Chinese patient with Fanconi anemia (zeige PALB2 Antikörper).
Using small interfering RNA (siRNA), knockdown of FANCF (zeige FANCF Antikörper), FANCL, or FANCD2 (zeige FANCD2 Antikörper) inhibited function of the FA/BRCA pathway in A549, A549/DDP (zeige TIMM8A Antikörper) and SK-MES (zeige ME1 Antikörper)-1 cells, and potentiated sensitivity of the three cells to cisplatin.
Loss-of-Function FANCL Mutations Associate with Severe Fanconi Anemia (zeige PALB2 Antikörper) Overlapping the VACTERL Association
a signal transduction pathway involved in self-renewal and survival of hematopoietic stem cells also functions to stabilize FANCL and suggesting that FANCL participates directly in support of stem cell function.
Suppression of FANCL expression in normal CD34(+) stem and (zeige CTNNB1 Antikörper)progenitor cells results in fewer beta-catenin active cells and inhibits expansion of multilineage progenitors.
FA DNA repair genes, FANCD2 (zeige FANCD2 Antikörper), FANCL, and FANCC (zeige FANCC Antikörper), are transcriptionally upregulated differently in melanoma compared with non-melanoma skin cancer
genetic diversity in FANCA (zeige FANCA Antikörper), FANCC (zeige FANCC Antikörper) and FANCL does not support an association of these genes with cervical cancer susceptibility in the Swedish population.
FANCL is associated with acute lung injury in mice
expression of a novel splice variant of FA complementation group L (FANCL), named FAVL, can impair the FA pathway in non-FA tumor cells and act as a tumor promoting factor
data suggest that PHF9 has a crucial role in the Fanconi anemia (zeige PALB2 Antikörper) pathway as the likely catalytic subunit required for monoubiquitination of FANCD2 (zeige FANCD2 Antikörper)
The authors report the structure of the human FANCL central domain and show that the RING domain is necessary and sufficient for E2 binding.
Using HeLa cells and lymphoblasts from Fanconi anemia (zeige PALB2 Antikörper) patients, the authors characterize PHF9 (FANCL) as a ubiquitin ligase (zeige RNF123 Antikörper) and show it is essential for FANCD2 (zeige FANCD2 Antikörper) monoubiquitination. The authors state that PHF9 is the human homolog of mouse Pog (Fancl).
FANCL increases the activity and expression of beta-catenin (zeige CTNNB1 Antikörper), a key pluripotency factor in hematopoietic stem cells.
UBE2W (zeige UBE2W Antikörper) regulates FANCD2 (zeige FANCD2 Antikörper) monoubiquitination by mechanisms different from UBE2T (zeige Ube2t Antikörper) and HRR6.
Fancl is associated with acute lung injury
Deletion of Pog causes germ cell deficiency, but is also accompanied by reduced embryonic body weight and sometimes lethality.
GGN1 and GGN3, interacted with POG, regulated the localization of POG, and played a role in spermatogenesis.
unlike in POG-deficient females, the germ cells in POG-deficient males eventually populate the seminiferous tubules at 9 wk, and fertility can be achieved by 12 wk.
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms.
E3 ubiquitin-protein ligase FANCL
, PHD finger protein 9
, fanconi anemia group L protein
, fanconi anemia-associated polypeptide of 43 kDa
, fanconi anemia group L protein homolog
, germ cell deficient
, proliferation of germ cells protein