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FAM20C encodes a member of the family with sequence similarity 20 (FAM20) family of secreted proteins. Zusätzlich bieten wir Ihnen FAM20C Proteine (3) und FAM20C Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Histidine-rich Ca-binding protein (HRC (zeige HRC Antikörper)) was phosphorylated by family with sequence similarity 20C (Fam20C) both in vitro and in vivo.
These results suggest that TET1 (zeige TET1 Antikörper) potentially promotes the cytodifferentiation potential of human dental pulp cells through its DNA demethylation machinery and upregulation of FAM20C protein expression.
Alterations of Fam20C activity, promoted by myriocin and sphingolipids, are not accompanied by any significant change in Fam20C protein. These data provide the proof of concept that Fam20C activity is under the control of sphingolipid signaling
Fam20A (zeige FAM20A Antikörper) potentiates Fam20C kinase activity and promotes the phosphorylation of enamel matrix proteins in vitro.
The Fam20C-and VLK (zeige PKDCC Antikörper)-family of kinases mediate the phosphorylation of proteins in the secretory pathway and extracellular space.Mutation in several secretory pathway kinases cause human disease
by treating Fam20C expressing HEK293T cells with myriocin, a potent inhibitor of the sphingosine biosynthetic pathway, the activity of Fam20C released into the conditioned medium is substantially decreased corroborating the concept that sphingosine
Using CRISPR/Cas9 genome editing, mass spectrometry, and biochemistry, study identifies more than 100 secreted phosphoproteins as genuine Fam20C substrates; further, study shows that Fam20C exhibits broader substrate specificity than previously appreciated.
phenotype in two families with non-lethal Raine syndrome with FAM20C mutations
Findings suggest that certain homozygous FAM20C mutations can cause FGF23 (zeige FGF23 Antikörper)-related hypophosphatemic osteomalacia and indicate the multiple roles of FAM20C in bone.
Results suggest that FAM20C suppresses FGF23 (zeige FGF23 Antikörper) production by enhancing DMP1 (zeige DMP1 Antikörper) expression, and inactivating mutations in FAM20C cause FGF23 (zeige FGF23 Antikörper)-related hypophosphatemia by decreasing transcription of DMP1 (zeige DMP1 Antikörper).
Loss of Fam20C function leads to periodontal disease in mice
Successful generation of Fam20C-GFP transgenic mice will provide a unique model for studying Fam20C gene expression and the biological function of this gene during odontogenesis and osteogenesis
we have successfully generated the immortalized mouse floxed Fam20c dental papilla mesenchymal and osteoblast cell lines.
These results indicated that the downregulation of Dmp1 (zeige DMP1 Antikörper) may not directly associate with, or significantly contribute to the bone and dentin defects in the Fam20C-cKO mice.
that FAM20C is not a constituent of the enamel extracellular matrix and functions intracellularly within ameloblasts.
FAM20C is a molecule essential to amelogenesis, its inactivation in the dental epithelium does not significantly affect dentinogenesis.
FAM20C is essential to the differentiation and mineralization of dental tissues through the regulation of molecules critical to the differentiation of tooth-formative cells.
Our findings indicate that FAM20C is essential to the differentiation of osteoblasts/osteocytes and is involved in the regulation of phosphate homeostasis via the mediation of FGF23 (zeige FGF23 Antikörper)
Fam20c null mice develop hypophosphatemic rickets and defective enamel and dentin
This gene encodes a member of the family with sequence similarity 20 (FAM20) family of secreted proteins. A similar gene in mice encodes a protein that plays a role in dentin mineralization, and mutations in the human gene are associated with the autosomal recessive disorder Raine syndrome.
family with sequence similarity 20, member C
, dentin matrix protein 4
, extracellular serine/threonine protein kinase FAM20C
, golgi-enriched fraction casein kinase