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FEV belongs to the ETS transcription factor family. Zusätzlich bieten wir Ihnen FEV (ETS Oncogene Family) Antikörper (11) und FEV (ETS Oncogene Family) Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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identified FEV is unique to fetal HSCs and stably expressed in leukemic cells of prenatal origin
novel evidence for the role of Pet-1 in human amygdala threat processing extends literature demonstrating the influence of genetic variation in the serotonin system on emotional regulation
Fev-ERK signaling is essential for hemogenic endothelium-based hematopoietic stem cell development.
our data argue against an exclusive role of FEV in the adult human brain serotonergic system and genetic analyses did not suggest that FEV variation adds to the genetic liability towards affective disorders
FEV identifies serotonin-producing cells in normal and neoplastic small intestine.
Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American population.
FEV acts as a transcriptional repressor through its DNA-binding ETS (zeige ETS1 Proteine) domain and alanine-rich domain.
We showed that fev is exclusively expressed in the midline part of the human brainstem containing raphe nuclei, which also specifically expressed 5-HT (zeige DDC Proteine) transporter (sert (zeige SLC6A4 Proteine)) and tryptophan hydroxylase (tph (zeige TPH1 Proteine)), two markers of the 5-HT (zeige DDC Proteine) neurotransmitter system.
Analysis of transgene expression in Pet-1 null mice indicates that Pet-1 is required to maintain the activity of the Pet-1 enhancer region in a subset of serotonin (5-HT (zeige DDC Proteine)) neurons.
Variation in FEV gene observed exclusively in a subset of African American sudden infant death syndrome cases may help explain the observed abnormalities of this system in some SIDS (zeige IDS Proteine) cases and the ethnic disparity.
These results suggest a causal relationship between 5-HT1A (zeige HTR1A Proteine) and Pet1, and reveal a potential mechanism by which 5-HT1A (zeige HTR1A Proteine)-Pet1 autoregulatory loop is maintained by serotonin.
novel evidence for the role of Pet-1 in fear processing and dendritic organization of amygdala neurons
Pet1-dependent and Pet1-resistant 5-serotonin (5-HT (zeige DDC Proteine)) neurons target different brain centers that might delineate the anatomical basis for a dual serotonergic control on stress responses.
The data of this study indicated that, in addition to transcriptional regulation by Pet-1 in raphe neurons, 5-HT1A receptor (zeige CC2D1A Proteine) expression is regulated indirectly by alterations in 5-HT (zeige DDC Proteine) neurotransmission in a region-specific manner
This study indicated that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription.
Pet-1(-/-) neonates are probably not hypoxic from respiratory dysfunction until P14 (zeige PCOLCE Proteine)-15; neither apnea-related hypoxia nor greater hypopnea contribute to the enhanced bradycardias of Pet-1 and there may be enhanced temperature reflex in hyperthermia
expressed in central serotonergic (5-hydroxytryptaminergic) neurons located in the mes (zeige PTCH1 Proteine)-/metencephalic raphe nuclei from E11 (zeige PDPN Proteine) on until adulthood
Pet-1 is a critical determinant of 5-HT (zeige DDC Proteine) neuron identity and Pet-1-dependent program is involved in serotonergic modulation of behavior
Ectopic expression of Lmx1b (zeige LMX1B Proteine) plus Pet-1 is able to induce formation of 5-HT (zeige DDC Proteine) cells in the most ventral spinal cord, where Nkx2.2 (zeige Nkx2-2 Proteine) is normally expressed. Combined expression of Lmx1b (zeige LMX1B Proteine), Pet-1, and Nkx2.2 (zeige Nkx2-2 Proteine), drives 5-HT (zeige DDC Proteine) differentiation in the dorsal spinal cord
Our findings identify a direct transcriptional interaction between Gata-2 (zeige GATA2 Proteine) and FEV and a unique marker for new insight into FEV/Pet-1 function in 5-HT (zeige DDC Proteine) neuron development.
Spatiotemporal expression profile of the Ets-domain transcription factor-encoding gene pet1 in developing and adult zebrafish.
This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations.
, FEV (ETS oncogene family)
, PC12 ETS domain-containing transcription factor 1
, fifth Ewing variant protein
, ETS-domain transcription factor Pet-1
, FEV (fifth Ewing variant)
, PC12 ETS factor 1
, pheochromocytoma 12 ETS (E26 transformation-specific)
, ETS domain transcription factor Pet-1
, ETS domain transcription factor
, protein Pet-1