Eukaryotic Translation Initiation Factor 4E (EIF4E) ELISA Kits

The protein encoded by EIF4E is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. Zusätzlich bieten wir Ihnen EIF4E Antikörper (257) und EIF4E Proteine (16) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
EIF4E 1977 P06730
Anti-Maus EIF4E EIF4E 13684 P63073
Anti-Ratte EIF4E EIF4E 117045 P63074
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Weitere ELISA Kits für EIF4E Interaktionspartner

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 4E (EIF4E) Interaktionspartner

  1. The structures of eIF4E-eIF4G complexes reveal an extended interface to regulate translation initiation.

  2. Phosphorylation of 4E-BP1 (zeige EIF4EBP1 ELISA Kits) impairs the competition with eIF4G for eIF4E binding.

  3. Both eIF4E-1 and eIF4E-3 are required in spermatocytes for chromosome condensation and cytokinesis during the meiotic stages.

  4. eIF4E-binding protein (zeige EIF4EBP1 ELISA Kits) requires non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.

  5. Protein-protein interactions rather than interactions with the mRNA are essential for the recruitment of eIF4E and for a putative nucleation function.

  6. Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.

  7. eIF4E regulates the sex-specific expression of the master switch gene Sxl.

  8. data are consistent with the idea that Parkin (zeige PARK2 ELISA Kits) and eIF4E act in a common pathway, likely modulating cap-dependent translation initiation events.

  9. results show that LK6 binds to ERK (zeige MAPK1 ELISA Kits) and is activated by ERK (zeige MAPK1 ELISA Kits) signalling and it is responsible for phosphorylating eIF4E in Drosophila

  10. our results suggest that the level of eIF4E protein is regulated by Diap1 (zeige DIAPH1 ELISA Kits), and that IAPs may play a role in cap-dependent translation by regulating the level of eIF4E protein.

Xenopus laevis Eukaryotic Translation Initiation Factor 4E (EIF4E) Interaktionspartner

  1. Pumilio 2 controls translation by competing with eIF4E for 7-methyl guanosine cap recognition.

  2. CDK1 (zeige CDK1 ELISA Kits) and calcineurin regulate Maskin association with eIF4E and translational control of cell cycle progression

  3. CPEB, partnered with several highly conserved RNA-binding partners, inhibits protein synthesis in oocytes using a novel pairing of 4E-T and eIF4E1b

Human Eukaryotic Translation Initiation Factor 4E (EIF4E) Interaktionspartner

  1. Our results indicate that AURKA (zeige AURKA ELISA Kits) plays an important role in the activation of EIF4E and cap-dependent translation. Targeting the AURKA (zeige AURKA ELISA Kits)-EIF4E-c-MYC (zeige MYC ELISA Kits) axis using alisertib is a novel therapeutic strategy that can be applicable for everolimus-resistant tumors and/or subgroups of cancers that show overexpression of AURKA (zeige AURKA ELISA Kits) and activation of EIF4E and c-MYC (zeige MYC ELISA Kits)

  2. Treatment with 240 mg/l matrine reduced the protein expression levels of PCNA (zeige PCNA ELISA Kits) and eIF4E. Matrine also reduced the migration ability of A549 cells and inhibited their proliferation, which may be associated with the overexpression of p53 (zeige TP53 ELISA Kits) and p21 (zeige CDKN1A ELISA Kits), and the reduction of PCNA (zeige PCNA ELISA Kits) and eIF4E expression levels.

  3. eIF4E and MMP9 (zeige MMP9 ELISA Kits) expression in endometrial cancer specimens suggests their potential up-regulation during carcinogenesis.

  4. eIF4E promoted cholangiocarcinoma cell metastasis by up-regulating the expression of VEGF-C (zeige VEGFC ELISA Kits), MMP-2 (zeige MMP2 ELISA Kits) and suppressing E-cadherin (zeige CDH1 ELISA Kits) expression.

  5. Translational initiation pathway inhibition could be of clinical utility in male breast cancer patients overexpressing eIF4E and eIF5. With mTOR (zeige FRAP1 ELISA Kits) inhibitors that target this pathway now in the clinic, these biomarkers may represent new targets for therapeutic intervention, although further independent validation is required

  6. Data show association of eIF4E expression with chemotherapeutic response in esophageal squamous cell carcinoma (ESCC), and suggest that therapeutically targeting eIF4E may be a viable means of improving chemotherapy response in ESCC.

  7. We performed bioinformatics analyses of ESTs and the 3'UTRs of the main transcript splice variants of the translational initiation factor eIF4E1 and its family members, eIF4E2 and eIF4E3. We propose to elucidate the minor splice variants of eIF4E2 and eIF4E3 in great detail because they might produce proteins with modified features that fulfill different cellular roles from their major counterparts.

  8. EIF4E associated signaling pathways are associated with lymphangiogenesis and lymph node metastases of hypopharyngeal cancer.

  9. The authors show that LARP1 directly binds the cap and adjacent 5'TOP motif of TOP mRNAs, effectively impeding access of eIF4E to the cap and preventing eIF4F (zeige EIF4A2 ELISA Kits) assembly. Thus, LARP1 is a specialized TOP mRNA cap-binding protein that controls ribosome biogenesis.

  10. Mitogen-activated protein kinase (zeige MAPK1 ELISA Kits) interacting protein (zeige CIB1 ELISA Kits) kinases (Mnks) control translation by phosphorylation of eIF4E, whereas the mTOR (zeige FRAP1 ELISA Kits) kinase phosphorylates/de-activates the eIF4E inhibitor, 4E-BP1 (zeige EIF4EBP1 ELISA Kits), to release translational repression.

Mouse (Murine) Eukaryotic Translation Initiation Factor 4E (EIF4E) Interaktionspartner

  1. Lack of Def6 results in deregulation of Bcl6 (zeige BCL6 ELISA Kits) protein synthesis in T cells as a result of enhanced activation of the mTORC1-4E-BP-eIF4E axis.

  2. Mitogen-activated protein kinase (zeige MAPK1 ELISA Kits) interacting protein (zeige CIB1 ELISA Kits) kinases (Mnks) control translation by phosphorylation of eIF4E, whereas the mTOR (zeige FRAP1 ELISA Kits) kinase phosphorylates/de-activates the eIF4E inhibitor, 4E-BP1 (zeige EIF4EBP1 ELISA Kits), to release translational repression.

  3. PRMT1 inhibition prevents gastric cancer progression by downregulating eIF4E and targeting type II PRMT5.

  4. Our work demonstrates that a single phosphorylation site on the 5' cap-binding protein eIF4E is a critical mechanism for changes in nociceptor excitability that drive the development of chronic pain.

  5. data suggest a physiological role for MNK1a-Ser (zeige SIGLEC1 ELISA Kits)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E phosphorylation in vitro and in vivo.

  6. Results of our study suggest that the eIF4E/Fmr1 (zeige FMR1 ELISA Kits) double mutant mouse may be a reliable model to study cognitive dysfunction in the context of autism spectrum disorder.

  7. Our findings identify the eIF4E- beta-catenin (zeige CTNNB1 ELISA Kits) axis as a critical regulator of lung cancer cell growth and survival, and suggest that its pharmacological inhibition may be therapeutically useful in lung cancer.

  8. Unphosphorylated HSP27 (zeige HSPB1 ELISA Kits) associates with eIF4E in osteoblasts and suppresses the translation initiation process.

  9. Rotenone induction of hydrogen peroxide inhibits mTOR (zeige FRAP1 ELISA Kits)-mediated S6K1 (zeige RPS6KB1 ELISA Kits) and 4E-BP1 (zeige EIF4EBP1 ELISA Kits)/eIF4E pathways, resulting in caspase (zeige CASP3 ELISA Kits)-dependent and -independent apoptosis in neuronal cells.

  10. Findings indicate eIF4E is maintained at levels in excess for normal development that are hijacked by cancer cells to drive a translational program supporting tumorigenesis.

Pig (Porcine) Eukaryotic Translation Initiation Factor 4E (EIF4E) Interaktionspartner

  1. These data suggest that sapovirus VPg can hijack the cellular translation initiation mechanism by recruiting the eIF4F (zeige EIF4A2 ELISA Kits) complex through a direct eIF4E interaction

  2. it is proposed that a balanced regulation of the truncation of the cap-binding complex component eIF4F and degradation of 4E-BP1 and/or truncation of 4E-BP2 that together ensures correct translational control during the dynamic process of conceptus implantation

  3. Results show that in pigs, the truncated eIF4E is located in the endometrial luminal epithelium during implantation. Neither glandulary tissue nor stroma expressed any truncated eIF4E.

  4. The translation initiation in the endometrium is differently regulated by the two eIF4E forms with regard to different 4E-BP1 (zeige EIF4EBP1 ELISA Kits) abundance and phosphorylation as well as different eIF4E/4E-BP1 (zeige EIF4EBP1 ELISA Kits) binding dynamic depending on the type of implantation.

  5. Modified translational initiation of eIF4E may particularly regulate protein synthesis during conceptus attachment at the time of implantation in swine.

  6. Translation initiation factor eIF4E is phosphorylated during in vitro maturation of pig oocytes with a maximum in metaphase II stage oocytes.

EIF4E Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit EIF4E

  • Eukaryotic initiation factor 4E (eIF-4E) Antikörper
  • eucaryotic initiation factor 6 (eif6) Antikörper
  • eukaryotic translation initiation factor 4E (eif4e) Antikörper
  • eukaryotic translation initiation factor 4E family member 1B S homeolog (eif4e1b.S) Antikörper
  • eukaryotic translation initiation factor 4E (EIF4E) Antikörper
  • eukaryotic translation initiation factor 4E (Eif4e) Antikörper
  • eukaryotic translation initiation factor 4E L homeolog (eif4e.L) Antikörper
  • eukaryotic translation initiation factor 4ea (eif4ea) Antikörper
  • translation initiation factor eIF4E (LOC100533326) Antikörper
  • 2 Antikörper
  • 0260/09 Antikörper
  • 0587/11 Antikörper
  • 0589/11 Antikörper
  • 0919/12 Antikörper
  • 1004/13 Antikörper
  • 7238 Antikörper
  • AUTS19 Antikörper
  • cbp Antikörper
  • CG4035 Antikörper
  • CT13384 Antikörper
  • CT39424 Antikörper
  • CT39426 Antikörper
  • D-eIF4E Antikörper
  • deIF-4E Antikörper
  • deIF4E Antikörper
  • Dmel\\CG4035 Antikörper
  • EG668879 Antikörper
  • EIF-4E Antikörper
  • eIF-4E1 Antikörper
  • eIF-4E2 Antikörper
  • eIF-4EII Antikörper
  • eif4e Antikörper
  • eIF 4E Antikörper
  • eif4e-1 Antikörper
  • eIF4E-1/2 Antikörper
  • eIF4E-2 Antikörper
  • Eif4e-ps Antikörper
  • EIF4E1 Antikörper
  • eIF4EI Antikörper
  • EIF4EL1 Antikörper
  • EIF4F Antikörper
  • If4e Antikörper
  • l(3)07238 Antikörper
  • l(3)67Af Antikörper
  • l(3)S025007 Antikörper
  • l(3)S026009 Antikörper
  • l(3)S058711 Antikörper
  • l(3)S091912 Antikörper
  • zgc:86680 Antikörper

Bezeichner auf Proteinebene für EIF4E

CG4035-PA , CG4035-PB , CG4035-PC , CG4035-PD , CG4035-PE , CG4035-PF , CG4035-PG , CG4035-PH , CG4035-PI , cap binding protein , eIF-4E-PA , eIF-4E-PB , eIF-4E-PC , eIF-4E-PD , eIF-4E-PE , eIF-4E-PF , eIF-4E-PG , eIF-4E-PH , eIF-4E-PI , eukaryotic initiation factor 4E , eukaryotic translation initiation factor 4E , lethal(3)67Af , eucaryotic initiation factor6 , eIF4E , PCO081734 , PCO081734_ov , mRNA cap-binding protein , eukaryotic translation initiation factor small subunit , eIF-4F 25 kDa subunit , eIF-4E , eukaryotic translation initiation factor 4E-like 1 , elongation initiation factor 4E , eukaryotic translation initiation factor 4e 1a , eukaryotic translation initiation factor eIF4E-1

GENE ID SPEZIES
45525 Drosophila melanogaster
542608 Zea mays
548663 Xenopus (Silurana) tropicalis
399255 Xenopus laevis
1977 Homo sapiens
13684 Mus musculus
117045 Rattus norvegicus
422703 Gallus gallus
734259 Xenopus laevis
281751 Bos taurus
100009338 Oryctolagus cuniculus
487870 Canis lupus familiaris
100038030 Sus scrofa
79380 Danio rerio
100533326 Aplysia californica
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