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Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. Zusätzlich bieten wir Ihnen EIF4G2 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal EIF4G2 Primary Antibody für WB - ABIN1944751
Imataka, Olsen, Sonenberg: A new translational regulator with homology to eukaryotic translation initiation factor 4G. in The EMBO journal 1997
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Human Monoclonal EIF4G2 Primary Antibody für FACS, WB - ABIN265943
Levy-Strumpf, Deiss, Berissi, Kimchi: DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death. in Molecular and cellular biology 1997
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Human Monoclonal EIF4G2 Primary Antibody für IHC (p), ELISA - ABIN560721
Katsogiannou, Andrieu, Baylot, Baudot, Dusetti, Gayet, Finetti, Garrido, Birnbaum, Bertucci, Brun, Rocchi: The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. in Molecular & cellular proteomics : MCP 2014
The percentage at the S-stage was decreased in the miR (zeige MLXIP Antikörper)-379 mimics and EIF4G2 shRNA groups.
DAP5 knockdown from human ESCs (zeige NR2E3 Antikörper) (hESCs) resulted in persistence of pluripotent gene expression, delayed induction of differentiation-associated genes in different cell lineages, and defective embryoid body formation
Data show that microRNA miR (zeige MLXIP Antikörper)-379 potentiated lung cancer (LCa (zeige CLTA Antikörper)) chemosensitivity via modulation of cisplatin (CDDP)-induced apoptosis by directly targeting the eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) 3' UTR (zeige UTS2R Antikörper).
These results indicate that miR (zeige MLXIP Antikörper)-139 is capable of inhibiting chondrocyte proliferation and migration, thus being a possible therapeutic target for OA. The mechanism of miR (zeige MLXIP Antikörper)-139 in chondrocytes may be related to its regulation on EIF4G2 and IGF1R (zeige IGF1R Antikörper).
The Coxsackievirus B3 protease 2A-mediated cleavage of DAP5 results in the production of two truncates that exert differential effects on protein translation of the IRES-containing genes, leading to enhanced host cell death.
Knockdown of EIF4G2 recapitulated the effects of mir (zeige MLXIP Antikörper)-139, whereas restoring EIF4G2 expression rescued the mir (zeige MLXIP Antikörper)-139 phenotype. elevated miR (zeige MLXIP Antikörper)-139-5p expression is associated with a favorable outcome in acute myeloid leukemia (zeige BCL11A Antikörper).
findings provide the first mechanistic insights into the function of DAP5 as a selective regulator of cap-independent translation
Our results provide evidence that the tumor suppressor effect of miR (zeige MLXIP Antikörper)-520c-3p is mediated through repression of translation while inducing senescence and that eIF4GII (zeige EIF4G3 Antikörper) is a key effector of this anti-tumor activity.
DAP5, a translation initiation factor shown to positively regulate the translation of various internal ribosome entry sites containing mRNAs, promotes internal ribosome entry site-driven translation of p53 (zeige TP53 Antikörper) mRNA.
DAP5/p97 and DAP5/p86 enhanced the translation of the anti-apoptotic protein Bcl-2 (zeige BCL2 Antikörper) and inhibited cisplatin-induced apoptosis
analysis of the tandem MA-3 (zeige PDCD6 Antikörper) region of Pdcd4 (zeige PDCD4 Antikörper) protein and characterization of its interactions with eIF4A (zeige EIF4A1 Antikörper) and eIF4G (zeige EIF4G1 Antikörper)
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3\; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
eukaryotic translation initiation factor 4 gamma, 2
, eukaryotic translation initiation factor 4 gamma 2
, Eukaryotic translation initiation factor 4 gamma 2
, aging-associated protein 1
, death-associated protein 5
, eIF-4-gamma 2
, eIF-4G 2
, eIF4G 2
, eukaryotic translation initiation factor 4G-like 1
, eIF4G-related protein NAT1
, novel APOBEC-1 target 1
, translation repressor NAT1
, translation repressor Nat1