Euchromatic Histone-Lysine N-Methyltransferase 1 (EHMT1) ELISA Kits

The protein encoded by EHMT1 is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. Zusätzlich bieten wir Ihnen EHMT1 Antikörper (133) und EHMT1 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
EHMT1 77683 Q5DW34
EHMT1 79813 Q9H9B1
Anti-Ratte EHMT1 EHMT1 362078  
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human < 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests Anmelden zum Anzeigen 11 bis 18 Tage
$810.17
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Maus < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Anmelden zum Anzeigen 11 bis 18 Tage
$810.17
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Weitere ELISA Kits für EHMT1 Interaktionspartner

Mouse (Murine) Euchromatic Histone-Lysine N-Methyltransferase 1 (EHMT1) Interaktionspartner

  1. EHMT1 deficiency impaired neural network activity during the transition from uncorrelated background action potential firing to synchronized network bursting. Spontaneous bursting and excitatory synaptic currents were transiently reduced, whereas miniature excitatory postsynaptic currents were not affected.

  2. GLP/G9a (zeige EHMT2 ELISA Kits) H3K9 methyltransferase complex is an enzyme counteracting Jmjd1a-mediated H3K9 demethylation at the Sry (zeige SRY ELISA Kits) locus in gonadal somatic cells

  3. miR (zeige MLXIP ELISA Kits)-217-mediated, genetic, or pharmacological inactivation of EHMT1/2 was sufficient to promote pathological hypertrophy

  4. EHMT1 Mediates Homeostatic Synaptic Scaling

  5. The stress-induced Brg1 (zeige SMARCA4 ELISA Kits)-G9a (zeige EHMT2 ELISA Kits)/GLP-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (zeige MYH6 ELISA Kits) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.

  6. data provide genetic and pharmacologic evidence that EHMT1 and EHMT2 (zeige EHMT2 ELISA Kits) are epigenetic regulators involved in gamma-globin repression and represent a novel therapeutic target for SCD (zeige SCD ELISA Kits).

  7. histone methyltransferase activities of GLP and G9a (zeige EHMT2 ELISA Kits) are stimulated by neighboring nucleosomes that are premethylated at H3K9

  8. Prdm16 (zeige PRDM16 ELISA Kits) was required in young mice to suppress the expression of white-fat-selective genes in BAT through recruitment of the histone methyltransferase Ehmt1.

  9. G9a and GLP have an essential role in normal morphogenesis of the atrioventricular septum through regulation of the size of the atrioventricular cushion.

  10. Reduced Euchromatin histone methyltransferase 1 (zeige DNMT1 ELISA Kits) causes developmental delay, hypotonia, and cranial abnormalities associated with increased bone gene expression in Kleefstra syndrome mice.

Human Euchromatic Histone-Lysine N-Methyltransferase 1 (EHMT1) Interaktionspartner

  1. Neurodevelopmental disorders may be related to deficits in activity-dependent wiring of brain circuits during development. Although Kleefstra syndrome has been associated with dendritic and synaptic defects in mice and Drosophila, little is known about the role of EHMT1 in the development of cortical neuronal networks. We investigated the impact of EHMT1 deficiency at the network and single cell level.

  2. These results suggest that EHMT2 (zeige EHMT2 ELISA Kits) downregulation in CD4 (zeige CD4 ELISA Kits)(+) T-cells may be linked to a protection mechanism against the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP (zeige THBS1 ELISA Kits)).

  3. Regulated methylation and phosphorylation serve as a switch controlling G9a and GLP coactivator function, suggesting that this mechanism may be a general paradigm for directing specific transcription factor and coregulator actions on different genes.

  4. trr (zeige TXNRD1 ELISA Kits) and G9a (zeige EHMT2 ELISA Kits) also have common direct targets, including the Drosophila ortholog of Arc (Arc1 (zeige CDH1 ELISA Kits)), a key regulator of synaptic plasticity. Our data highlight the clinical and molecular convergence between the KMT2 and EHMT protein families, which may contribute to a molecular network underlying a larger group of intellectual disability / autism spectrum disorder -related disorders.

  5. missense variants in EHMT1 that lead to protein misfolding and disrupted histone mark binding can lead to Kleefstra Syndrome [case reports]

  6. we find an estrogen receptor-independent synthetic lethal interaction between a GATA3 frameshift mutant with an extended C-terminus and the histone methyltransferases G9A and GLP, indicating perturbed epigenetic regulation

  7. Selective degradation of the mutant EHMT1 mRNA leads to Kleefstra syndrome.

  8. G9a and GLP are required for stable maintenance of imprinted DNA methylation in embryonic stem cells.

  9. the clinical picture we found in Norwegian patients with Kleefstra syndrome is similar to the findings described in the literature. An interesting point is that in the literature >85% of the patients have a deletion of 9q34.3 and the remaining have a mutation in the EHMT1 gene, whereas in this study we found 50% with a deletion, and 50% with a mutation.

  10. Data indicate zinc finger proteins ZNF644 and WIZ as two core subunits in the histone-lysine N-methyltransferase G9a/GLP complex, and interact with the transcription activation domain of G9a and GLP.

EHMT1 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome). Two transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit EHMT1

  • euchromatic histone lysine methyltransferase 1 (EHMT1) Antikörper
  • histone-lysine N-methyltransferase EHMT2 (LOC100121084) Antikörper
  • euchromatic histone-lysine N-methyltransferase 1 (ehmt1) Antikörper
  • euchromatic histone lysine methyltransferase 1 (ehmt1) Antikörper
  • euchromatic histone methyltransferase 1 (Ehmt1) Antikörper
  • euchromatic histone lysine methyltransferase 1 (Ehmt1) Antikörper
  • 9230102N17Rik Antikörper
  • bA188C12.1 Antikörper
  • D330003E03 Antikörper
  • EHMT1 Antikörper
  • Eu-HMTase1 Antikörper
  • EUHMTASE1 Antikörper
  • FP13812 Antikörper
  • G9a Antikörper
  • GLP Antikörper
  • GLP1 Antikörper
  • KMT1D Antikörper
  • mKIAA1876 Antikörper

Bezeichner auf Proteinebene für EHMT1

euchromatic histone methyltransferase 1 , histone-lysine N-methyltransferase, H3 lysine-9 specific 5 , euchromatic histone-lysine N-methyltransferase 1 , histone-lysine N-methyltransferase EHMT1 , histone-lysine N-methyltransferase, H3 lysine-9 specific 5-like , G9a-like protein 1 , lysine N-methyltransferase 1D , G9a like protein , H3-K9-HMTase 5 , histone H3-K9 methyltransferase 5

GENE ID SPEZIES
417250 Gallus gallus
464891 Pan troglodytes
491224 Canis lupus familiaris
528606 Bos taurus
100023838 Monodelphis domestica
100058869 Equus caballus
100078328 Ornithorhynchus anatinus
100121084 Nasonia vitripennis
100124713 Xenopus (Silurana) tropicalis
100217666 Taeniopygia guttata
100466861 Ailuropoda melanoleuca
100538392 Meleagris gallopavo
100565730 Anolis carolinensis
77683 Mus musculus
79813 Homo sapiens
362078 Rattus norvegicus
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