Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41) ELISA Kits

The protein encoded by EPB41, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. Zusätzlich bieten wir Ihnen Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) Antikörper (66) und Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
EPB41 2035 P11171
EPB41 269587 P48193
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Weitere ELISA Kits für Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) Interaktionspartner

Zebrafish Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41) Interaktionspartner

  1. The results indicate that the gene product of ZF4.1R is essential for normal morphological shape of the developing heart and to support the repetitive cycles of its muscle contraction and relaxation.

  2. This study defines unique structural and functional properties for ZF4.1R.

Human Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41) Interaktionspartner

  1. 6 Single Nucleotide Polymorphisms within the EPB41 gene are significantly associated with Mandibular Prognathism (rs2762686, rs2788888, rs4654388, rs502393, rs11581096, and rs488113). The G-allele of SNP, assigned as rs4654388, showed the strongest link with an increased risk of Mandibular Prognathism in the Chinese population.

  2. Using Next-Generation sequencing, we identified the causative genetic mutations in fifteen patients with clinically suspected hereditary elliptocytosis and hereditary pyropoikilocytosis and correlated the identified mutations with the clinical phenotype and ektacytometry profile.

  3. Our study shows alternative polyadenylation to be an additional mechanism for the generation of 4.1 protein diversity in the already complex EPB41-related genes. Understanding the diversity of EPB41 RNA processing is essential for a full appreciation of the many 4.1 proteins expressed in normal and pathological tissues.

  4. identification of EPB41 as a hepatocellular carcinoma susceptibility gene in vitro and in vivo; consistent with this notion, EPB41 expression is significantly decreased in HCC tissue specimens, especially in portal vein metastasis or intrahepatic metastasis, compared to normal tissues

  5. The 4.1R, 4.1N and 4.1B are all expressed at the lateral membrane as well as cytoplasm of epithelial cells, suggesting a potentially redundant role of these proteins.

  6. Calcium mediates the conformation-based 4.1R FERM domain binding to membrane proteins by calmodulin.

  7. Results suggest a previously unidentified role for the scaffolding protein 4.1R in locally controlling CLASP2 behavior, CLASP2 cortical platform turnover and GSK3 activity, enabling correct MT organization and dynamics essential for cell polarity.

  8. We conclude that PIP2 may play an important role as a modulator of apo-CaM binding to 4.1R(80) throughout evolution.

  9. Plasmodium falciparum PF3D7_0402000 was identified as a new binding partner for the major erythrocyte cytoskeletal protein, 4.1R.

  10. a novel gene region, EPB41, which may be associated with smoking cessation, along with gene regions in CNR1 that may be targeted to further elucidate the etiology of gender differences in smoking behaviors.

  11. 4.1R regulates NHE1 activity through a direct protein-protein interaction that can be modulated by intracellular pH and Na(+) and Ca(2+) concentrations.

  12. Further studies involving siRNA-mediated knockdowns of spectrin, adducin, or p4.1 revealed that those proteins are needed for efficient docking of enterohaemorrhagic Escherichia coli to host cells.

  13. This study characterizes the mechanism by which RBFOX2 regulates protein 4.1R exon 16 splicing through the downstream intronic element UGCAUG.

  14. apo-calmodulin stabilizes the 4.1R N-terminal domain through interaction with its beta-strand-rich C-lobe and provide a novel function for calmodulin, i.e. structural stabilization of 4.1R

  15. Data show that protein 4.1R is necessary for the localization of IQGAP1 to the leading edge of cells migrating into a wound, whereas IQGAP1 is not required for protein 4.1R localization.

  16. Data provide evidence that 4.1R has functional interactions with emerin and A-type lamin that impact upon nuclear architecture, centrosome-nuclear envelope association and the regulation of beta-catenin transcriptional co-activator activity.

  17. 4.1R plays a role in the phosphatidylserine exposure signaling pathway that is of fundamental importance in red cell turnover.

  18. Proteins in the membrane skeleton protein 4.1 family are weakly expressed in non-small cell lung cancer and are related to tumor cell differentiation.

  19. in addition to two known minor shortened and stable spliceoforms, a 4.1R splicing mutation activates an intronic cryptic splice site, which results in a nonsense mRNA major isoform, targeted to degradation in intact cells by Nonsense-mediated mRNA decay.

  20. Four EPB41 SNPs showed allelic and genotypic associations with MP in first stage. In the second stage, the allele rs4654388 showed the strongest significant association with MP. rs4654388 G-allele was associated with a significantly increased risk of MP.

Xenopus laevis Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41) Interaktionspartner

  1. Data hypothesize that protein 4.1 (4.1R) could function as a linker protein between cytokeratin and the actin-based cytoskeleton.

Cow (Bovine) Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41) Interaktionspartner

  1. 4.1G interacts with a subset of CNG channels and implicate this protein-protein interaction in organizing the spatial arrangement of CNG channels in the plasma membrane of retinal outer segments.

  2. Band 4.1 protein is found in a retinal cDNA library screened for proteins interacting with the intracellular C-terminus of the metabotropic glutamate receptor isoform 8a (mGluR8a).

Mouse (Murine) Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41) Interaktionspartner

  1. Formation of an erythroid-specific, protein 4.1R-dependent membrane skeleton is an important feature not only of definitive, but also of primitive, erythropoiesis in mammals.

  2. 4.1R plays an important role in transporting 5-aminolevulinic acid into cells via at least partly interaction with GAT1 and GAT2 transporters in 5-ALA-PDT.

  3. This suggests that 4.1R may influence myogenesis by preventing VHL-mediated myogenin degradation.

  4. The proportion of 4.1R-positive cells was significantly higher in the HF group than in the controls, which was confirmed by the positive mRNA expression of 4.1R. 4.1R localized mostly to the plasma membrane of myocardial cells and was upregulated with the progression of HF. This suggests that 4.1R may be associated with HF progression.

  5. suggest that 4.1R can prevent pathogenic autoimmunity in MS/EAE progression by suppressing the CD4(+) T cell activation

  6. Loss of 4.1/NuMA interaction results in spindle orientation defects and inhibition of Cdk1 causes increase in cortical NuMA localization

  7. a functional role for 4.1R in small intestinal calcium absorption through regulation of membrane expression of PMCA1b.

  8. At the intercalated disc 4.1R does not colocalise with the adherens junction protein, beta-catenin, but does overlap with the other plasma membrane signalling proteins, the Na/K-ATPase and the Na/Ca exchanger NCX1.

  9. Cell adhesion and signaling pathways regulated by alphavbeta8 integrin and Band 4.1B are essential for normal formation and function of the heart during embryogenesis.

  10. A conserved exonic splicing silencer element (CE(16)) in protein 4.1R exon 16 (E16) interacts with hnRNP A/B proteins & plays a role in repression of E16 splicing during early erythropoiesis

  11. We speculate that over the repetitive cycles of heart muscle contraction and relaxation, 4.1R is likely to locate, support, and coordinate functioning of key membrane-bound macromolecular assemblies.[Epb41]

  12. These results suggest that erythroid protein 4.1 plays a major role in volume regulation and physiologically downregulates Na/H exchange in mouse erythrocytes.

  13. 4.1R organizes a macromolecular complex of skeletal and transmembrane proteins at the junctional node.

  14. Cytoskeletal protein 4.1R affects repolarization and regulates calcium handling in the heart.

  15. Silencing of histone acetyltransferase Elongator complex scaffold (Elp1) or catalytic subunit (Elp3) cell-autonomously delays the migration and impairs the branching of projection neurons.

  16. 4.1R knockout mice exhibit bradycardia, prolonged action potentials & QT intervals, and anomalous ion channel activities. 4.1R has a role in the cellular accumulation of NaV1.5. Review.

  17. 4.1R gene expression involves transcriptional regulation coupled with a complex splicing regulatory network.

Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit EPB41

  • erythrocyte membrane protein band 4.1b (epb41b) Antikörper
  • erythrocyte membrane protein band 4.1 (EPB41) Antikörper
  • erythrocyte membrane protein band 4.1 (epb41) Antikörper
  • erythrocyte membrane protein band 4.1 L homeolog (epb41.L) Antikörper
  • erythrocyte membrane protein band 4.1 (Epb41) Antikörper
  • 4.1R Antikörper
  • AI415518 Antikörper
  • D4Ertd442e Antikörper
  • EL1 Antikörper
  • Elp-1 Antikörper
  • Elp1 Antikörper
  • Epb41 Antikörper
  • HE Antikörper
  • mKIAA4056 Antikörper
  • P4.1R Antikörper
  • wu:fb70c02 Antikörper

Bezeichner auf Proteinebene für EPB41

erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) , cha , mot , merlot , chablis , protein 4.1R , cytoskeletal protein 4.1 , protein 4.1 , protein 4.1-like , EPB4.1 , P4.1 , band 4.1 , erythrocyte surface protein band 4.1 , 4.1R , erythroid membrane skeletal protein 4.1 , erythroid protein 4.1

326287 Danio rerio
456689 Pan troglodytes
720360 Macaca mulatta
100038195 Xenopus (Silurana) tropicalis
100226658 Taeniopygia guttata
100350667 Oryctolagus cuniculus
100402250 Callithrix jacchus
100455211 Pongo abelii
100546883 Meleagris gallopavo
100563114 Anolis carolinensis
100596891 Nomascus leucogenys
2035 Homo sapiens
442955 Canis lupus familiaris
397741 Xenopus laevis
281753 Bos taurus
396493 Gallus gallus
100515614 Sus scrofa
269587 Mus musculus
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