Endoplasmic Reticulum Aminopeptidase 2 Proteine (ERAP2)

Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Zusätzlich bieten wir Ihnen Endoplasmic Reticulum Aminopeptidase 2 Antikörper (36) und Endoplasmic Reticulum Aminopeptidase 2 Kits (7) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ERAP2 64167 Q6P179
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 60 bis 65 Tage
Human Cells Human His tag 10 μg Anmelden zum Anzeigen 14 bis 16 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage

ERAP2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,

Weitere Proteine zu Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) Interaktionspartnern

Human Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) Interaktionspartner

  1. Increased aminopeptidase expression governed by altered transcript dynamics at both ERAP1 and ERAP2 is a key mechanism driving the degree to which these enzymes contribute to immune-mediated disease.

  2. this study shows the association of ERAP2 single nucleotide polymorphism and its haplotypes with psoriasis vulgaris, and its dependence on the presence or absence of the HLA-C*06:02 allele and age at disease onset

  3. ERAP1 and ERAP2 heterodimers have a role in mediating the processing pathway of MHC class I antigens

  4. These results indicated that the ERAP gene may play a critical role in HCV chronicity in this Chinese Han population

  5. ERAP1 and ERAP2 have significant and distinct effects on the HLA-B*27 peptidome, suggesting that both enzymes largely act as separate entities in vivo. This may explain their different patterns of association with AS.

  6. This review focuses on the ambivalent role of HLA-B27 in autoimmunity and viral protection correlating its functions to the quantitative and qualitative effects of ERAP1 and ERAP2 polymorphisms on their enzymatic activity.

  7. ERAP2 deficiency causes increased MHC class I free heavy chain expression and up-regulation of the unfolded protein response pathway in anklyosing spondylitis.

  8. ERAP-2 significantly influences the B*27:05-bound peptidome by destroying some ligands and decreasing the abundance of many more ligands with N-terminal basic residues, while increasing the abundance of nonamers. The former effects are best explained by direct ERAP-2 trimming. The effects on peptide length might be attributed to ERAP-2-induced activation of ERAP-1 trimming. These data support the notion of a peptide-media

  9. study reveals fine-mapped AID risk variants that act as eQTLs with ERAP2 in thymus

  10. there is a significant association of ERAP2 with psoriatic arthritis and HLA-B27 negative psoriatic arthritis, while ERAP1 association is restricted only to HLA-B27 positive disease

  11. Increased expression of ERAP2 in GC-responders before therapy warrants further investigation into their role as potential predictors for the response to GC, and in the inflammatory process of rheumatoid arthritis.

  12. ERAP2 is associated with ankylosing spondylitis in HLA-B27 positive and HLA-B27 negative patients.

  13. ERAP2 might be associated with CLNM in PTMC.

  14. ERAP2 variation does not have a significant effect on PBMC intracellular and cell surface HLA-class I expression and heavy chain formation, markers of ER stress or inflammatory cytokine production.

  15. Studies indicate the critical role of M1 aminopeptidases ERAP1, ERAP2 and NPEPPS in immune-mediated diseases.

  16. The risk allele of the polymorphism near ERAP2 is strongly associated with birdshot chorioretinopathy.

  17. Data indicate that dimerization of endoplasmic reticulum aminopeptidases ERAP1/2 creates complexes with superior peptide-trimming efficacy.

  18. concerted aminoproteolytic activity of ERAP 1 and ERAP2

  19. ERAP2 haplotype A is correlated with resistance to HIV-1 infection, possibly secondarily to its effect on antigen processing and presentation.

  20. ERAP1 and ERAP2 might be involved in the development of immune escape mechanisms of renal cell carcinoma.

Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) Protein Überblick

Protein Überblick

Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP1 (MIM 606832) and LRAP to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2\; MIM 190470) (Tanioka et al., 2003

Genbezeichner und Symbole assoziert mit ERAP2

  • endoplasmic reticulum aminopeptidase 2 (ERAP2)
  • endoplasmic reticulum aminopeptidase 2 (erap2)
  • ERAP2 Protein
  • L-RAP Protein
  • LRAP Protein
  • zgc:172163 Protein

Bezeichner auf Proteinebene für ERAP2

leukocyte-derived arginine aminopeptidase , endoplasmic reticulum aminopeptidase 2 , endoplasmic reticulum aminopeptidase 2-like

64167 Homo sapiens
461959 Pan troglodytes
513572 Bos taurus
700118 Macaca mulatta
100171433 Pongo abelii
100402550 Callithrix jacchus
100856345 Canis lupus familiaris
100073223 Equus caballus
100525036 Sus scrofa
100144556 Danio rerio
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