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The protein encoded by ELF5 is a member of an epithelium-specific subclass of the Ets transcritpion factor family. Zusätzlich bieten wir Ihnen ELF5 Proteine (5) und ELF5 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal ELF5 Primary Antibody für IHC (p), IHC - ABIN249582
Oettgen, Kas, Dube, Gu, Grall, Thamrongsak, Akbarali, Finger, Boltax, Endress, Munger, Kunsch, Libermann: Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes. in The Journal of biological chemistry 1999
Conditional inactivation of Elf5 in the developing collecting ducts results in a small but significant reduction in the expression levels of Aqp2 (zeige AQP2 Antikörper) and Avpr2 (zeige AVPR2 Antikörper) genes.
Mechanistically, RL negatively regulates Stat5 (zeige STAT5A Antikörper) phosphorylation and Elf5 expression at the onset of lactogenesis. Continuous RL exposure leads to the expansion of basal and bipotent cells in WT and MMTV-RANK acini. Overall, we demonstrate that enhanced Rank signaling impairs secretory differentiation during pregnancy by inhibition of the prolactin (zeige PRL Antikörper)/p-Stat5 (zeige STAT5A Antikörper) pathway.
Elf5 at the center of a stoichiometry-sensitive transcriptional network, where it acts as a molecular switch governing the balance between TSC (zeige SLC12A3 Antikörper) proliferation and differentiation
Elf5 and Ets2 (zeige ETS2 Antikörper) maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner
Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 (zeige SOX2 Antikörper) and 3 and inhibiting Hand1 (zeige HAND1 Antikörper) expression.
Blockade of RankL (zeige TNFSF11 Antikörper) action prevented progesterone-induced side branching and the expansion of Elf5(+) mature luminal cells.
Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2.
Studies suggest that Elf5 loss leads to hyperactivation of the Notch (zeige NOTCH1 Antikörper) signaling pathway, which might constitute in part, the underlying molecular mechanism for the altered cell lineage decisions in Elf5-null mammary epithelial cells.
Elf5 promoter methylation is regulated during mammary differentiation in vivo.
identify novel transcriptional targets of Elf5 and show that Muc4 (zeige MUC4 Antikörper) is a direct target of Elf5, further elucidating the mechanisms through which Elf5 regulates proliferation and differentiation in the mammary gland
When ELF5 was transfected into the parental MCF7 cells that lack CEACAM1 (zeige CEACAM1 Antikörper), lumen formation was restored, indicating that ELF5 can replace CEACAM1 (zeige CEACAM1 Antikörper) in this model system of lumenogenesis.
These results support the contention that ABO (zeige ABO Antikörper) expression is dependent upon a downstream positive regulatory element functioning through a tissue-restricted transcription factor, Elf5, in epithelial cells.
Low ELF5 expression is associated with ovarian cancer.
The results of this study suggest that ELF5 is a candidate gene that confers genetic susceptibility for pediatric asthma in the Taiwanese population and SNP rs3910901 may have a minor impact on pediatric asthma in the Taiwanese population.
a novel EWSR1 (zeige EWSR1 Antikörper)/ETS (zeige ETS1 Antikörper) chimeric gene, was identified in a patient diagnosed with refractory AML (zeige RUNX1 Antikörper), suggesting a potential role of leukemogenesis in rare cases of AML (zeige RUNX1 Antikörper). This fusion gene is very likely to exhibit oncogenic potential by interfering with the p53 (zeige TP53 Antikörper)/p21 (zeige CDKN1A Antikörper)-dependent pathway.
Alternative promoter use, conferring differential regulatory responses, is the main mechanism governing ELF5 action rather than differential transcriptional activity of the isoforms.
Data (including data from studies in transgenic mice) suggest that expression of ELF5 in luminal breast cancer correlates with increased myeloid cell invasion, inflammation, and lung metastasis.
we identified Elf5 as a novel biomarker of urothelial cancer on several biological levels and established a causative link between Elf5 and epithelial-mesenchymal transition in urothelial cancer.
Elf5 expression is inversely correlated with epithelial-mesenchymal transition in prostate cancer.
ELF5 provides a key transcriptional determinant of breast cancer molecular subtype by suppression of estrogen sensitivity in luminal breast cancer cells.
Elf5 regulation in the trophectoderm
The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
E74-like factor 5 (ets domain transcription factor)
, ETS-related transcription factor Elf-5
, Epithelium specific Ets-2
, epithelium-restricted ESE-1-related Ets factor
, epithelium-specific Ets transcription factor 2
, E74-like factor 5 ESE-2a