Dynein, Axonemal, Heavy Chain 11 Proteine (DNAH11)

DNAH11 encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. Zusätzlich bieten wir Ihnen DNAH11 Antikörper (24) und DNAH11 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
DNAH11 8701 Q96DT5
Maus DNAH11 DNAH11 13411  
Ratte DNAH11 DNAH11 117253  
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Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 15 bis 18 Tage
$420.00
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Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$672.00
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Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$668.03
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DNAH11 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human
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Weitere Proteine zu Dynein, Axonemal, Heavy Chain 11 (DNAH11) Interaktionspartnern

Human Dynein, Axonemal, Heavy Chain 11 (DNAH11) Interaktionspartner

  1. Dnah11(avc)(4) did not disrupt SHF (zeige SHF Proteine) Hh signaling and caused Atrioventricular septal defects (AVSDs) only concurrently with heterotaxy, a left/right axis abnormality. In contrast, Mks1 (zeige MKS1 Proteine)(avc)(6) disrupted SHF (zeige SHF Proteine) Hh signaling and caused AVSDs without heterotaxy.We speculate that cilia gene mutations contribute to both syndromic and non-syndromic AVSDs in humans

  2. DNAH11 mutations result in a subtle outer dynein arm defect in only the proximal region of respiratory cilia.

  3. In an epithelial cell line engineered to contain the DNAH11 target site, TALENs cleaved over 80% of the mutated DNAH11 sequence and replaced the mutated sequence with wild-type sequence in about 50% of cells. This study demonstrates that gene editing can rescue ciliary beating ex vivo, opening up new avenues for treating Primary ciliary dyskinesia.

  4. Mutations in DNAH11 are a common cause of PCD in patients without ciliary ultrastructural defects; thus, genetic analysis can be used to ascertain the diagnosis of PCD in this challenging group of patients.

  5. mutations: splice site in acceptor splice site of exon 5 and nonsense mutation located in exon 23 for DNAH11 in primary ciliary dyskinesia

  6. mutations in the DNAH11 gene cause one form of situs inversus totalis and most likely primary ciliary dyskinesia

  7. Dynein plays an unexpected role in the regulation of mitochondrial morphology in living cells, by controlling the recruitment of Drp1 (zeige CRMP1 Proteine) to these organelles.

  8. a specific requirement for p150(Glued (zeige DCTN1 Proteine))/dynein/functional microtubules in activation of MKK3 (zeige MAP2K3 Proteine)/6 and p38 (zeige CRK Proteine) MAPKs in vivo.

  9. These findings support the view that DNAH11 mutations indeed cause Primary ciliary dyskinesia and Kartagener syndrome, and that the reported DNAH11 nonsense mutations are associated with a normal axonemal ultrastructure.

  10. Two "major" genes, DNAI1 and DNAH5, underlie PCD in nearly half of the patients with ODA defects

Mouse (Murine) Dynein, Axonemal, Heavy Chain 11 (DNAH11) Interaktionspartner

  1. Dnah11(avc)(4) did not disrupt SHF (zeige SHF Proteine) Hh signaling and caused Atrioventricular septal defects (AVSDs) only concurrently with heterotaxy, a left/right axis abnormality. In contrast, Mks1 (zeige MKS1 Proteine)(avc)(6) disrupted SHF (zeige SHF Proteine) Hh signaling and caused AVSDs without heterotaxy.We speculate that cilia gene mutations contribute to both syndromic and non-syndromic AVSDs in humans

  2. These data unveil a previously unrecognized role for the dynein-dynactin (zeige DCTN1 Proteine) motor complex in osteoclast formation and function.

  3. work supports the claim that LRD functions in a mechanism for selective chromatid segregation

DNAH11 Protein Überblick

Protein Überblick

This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility.

Genbezeichner und Symbole assoziert mit DNAH11

  • dynein axonemal heavy chain 11 (DNAH11)
  • dynein, axonemal, heavy chain 11 (Dnah11)
  • dynein heavy chain 11, axonemal (LOC497208)
  • dynein, axonemal, heavy chain 11 (DNAH11)
  • dynein heavy chain 11, axonemal (LOC100497531)
  • dynein axonemal heavy chain 11 (dnah11)
  • hypothetical protein LOC472305 (DNAH11)
  • dynein axonemal heavy chain 11 L homeolog (dnah11.L)
  • dynein axonemal heavy chain 11 (Dnah11)
  • b2b598Clo Protein
  • b2b1203Clo Protein
  • b2b1279Clo Protein
  • b2b1289Clo Protein
  • b2b1727Clo Protein
  • Bv1 Protein
  • CILD7 Protein
  • DNAHBL Protein
  • Dnahc11 Protein
  • DNHBL Protein
  • DPL11 Protein
  • iv Protein
  • lrd Protein

Bezeichner auf Proteinebene für DNAH11

axonemal beta dynein heavy chain 11 , axonemal dynein heavy chain 11 , ciliary dynein heavy chain 11 , dynein heavy chain 11, axonemal , dynein, axonemal, heavy polypeptide 11 , dynein, ciliary, heavy chain 11 , dynein, axon, heavy chain 11 , situs inversus viscerum , dynein, axonemal, heavy chain 11 , dynein heavy chain Bv1 , dynein heavy chain 11, axonemal-like , hypothetical protein LOC472305

GENE ID SPEZIES
8701 Homo sapiens
13411 Mus musculus
117253 Rattus norvegicus
482346 Canis lupus familiaris
497208 Bos taurus
100067501 Equus caballus
100497531 Xenopus (Silurana) tropicalis
100566880 Anolis carolinensis
100584743 Nomascus leucogenys
472305 Pan troglodytes
100462917 Xenopus laevis
100518444 Sus scrofa
100733692 Cavia porcellus
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