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DCX encodes a member of the doublecortin family. Zusätzlich bieten wir Ihnen Doublecortin Antikörper (166) und Doublecortin Proteine (12) und viele weitere Produktgruppen zu diesem Protein an.
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this suggests that the microtubule-interacting doublecortin domain observed in cryo-electron micrographs is the C-terminal domain rather than the N-terminal one.
From this family, we conclude that a DCX mutation causes a pleiotropic phenotype in the female even if X chromosome inactivation pattern is not skewed, and the novel missense mutation in DCX produced relatively mild dysfunction of the doublecortin protein.
We identified a novel DCX mutation c.785A > G, p.Asp262Gly in a family with X-linked lissencephaly and subcortical band heterotopia
In high-risk metastatic Neuroblastoma, TH and DCX mRNA quantification could be used for the assessment of response to treatment and for early detection of progressive disease or relapses.
Results point to a critical role of doublecortin in the formation of the neuromuscular junctions.
DCX-positive cells occur in a wide range of hypothalamic nuclei in humans, mice and sheep.
human DCX protein was expressed in human adipose stem cells, collagen II was decreased while aggrecan (zeige ACAN ELISA Kits), matrilin 2 (zeige MATN2 ELISA Kits), and GDF5 (zeige GDF5 ELISA Kits) were increased during the 14-day pellet culture.
We propose that DCDC2 is a tumor suppressor gene of HCC.
in utero doublecortin knockdown, but not knockout, shows a neocortical neuronal migration phenotype.
Immunoblots revealed that depressed subjects displayed increased expression of doublecortin.
Authors found that 14-3-3epsilon binds to the microtubule binding protein, doublecortin (Dcx) in a phosphorylation dependent manner and that this binding increases the Dcx protein levels in the cell by interrupting ubiquitin based degradation.
MEIS2 associates with chromatin-bound PBX1 (zeige PBX1 ELISA Kits), recruits PARP1/ARTD1 (zeige PARP1 ELISA Kits), and initiates PARP1 (zeige PARP1 ELISA Kits)-mediated eviction of H1 from the chromatin fiber.
The regulation axis from microRNA-128-3p to doublecortin is critical for hippocampus-related contextual learning not only in wild type, but also in mice infused with Abeta (zeige APP ELISA Kits)-42.
Findings demonstrate the direct requirement of ADAM10 (zeige ADAM10 ELISA Kits) in cortical radial migration and reveal the underlying mechanism by linking ADAM10 (zeige ADAM10 ELISA Kits)-initiated regulated intramembrane proteolysis of Notch (zeige NOTCH1 ELISA Kits) to the regulation of microtubule cytoskeleton through transcriptional control of Dcx expression
Dcx is a new marker for the Pax7 (zeige PAX7 ELISA Kits)(+)MyoD (zeige MYOD1 ELISA Kits)(-) subpopulation, which contributes to myofiber maturation during muscle regeneration.
DCX-positive cells resembling immature and developing neurons were found in mice and sheep and human hypothalamus.
we showed that miR (zeige MLXIP ELISA Kits)-29a directly regulated its target protein Doublecortin (DCX) expression, which further modulated axon branching in primary culture.
Cdk5 (zeige CDK5 ELISA Kits) and its substrates, Dcx and p27kip1 (zeige CDKN1B ELISA Kits), regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons.
Doublecortin knockout mice show lamination defects of the hippocampal pyramidal cell layer largely restricted to the CA3 (zeige CA3 ELISA Kits) region.
Dcx protein- and mRNA-levels reflected changes in neurogenesis
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
doublecortex; lissencephaly, X-linked (doublecortin)
, neuronal migration protein doublecortin
, lissencephaly, X-linked (doublecortin)