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DLG2 encodes a member of the membrane-associated guanylate kinase (MAGUK) family.
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Mammalian Monoclonal DLG2 Primary Antibody für ISt, IHC - ABIN1304596
Chaudhury, He, Goyal: Role of PSD95 in membrane association and catalytic activity of nNOSalpha in nitrergic varicosities in mice gut. in American journal of physiology. Gastrointestinal and liver physiology 2010
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Human Polyclonal DLG2 Primary Antibody für ICC, IP - ABIN1742273
Requena, Parra, Baust, Quiroz, Leak, Garcia-Olivares, Torres: The molecular chaperone Hsc70 interacts with the vesicular monoamine transporter-2. in Journal of neurochemistry 2009
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Mammalian Monoclonal DLG2 Primary Antibody für ISt, IHC - ABIN1304597
Liu, Lee, Ackerman: Mutations in the microtubule-associated protein 1A (Map1a) gene cause Purkinje cell degeneration. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
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Guinea Pig Polyclonal DLG2 Primary Antibody für WB - ABIN2781502
Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006
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Two novel promoters and coding first exons in the DLG2 gene were identified. These novel isoforms are expressed in the fetal brain. Deletions of these new elements were found associated with neurodevelopmental disorders. The work brings evidence for the lack of cross-annotation in human versus mouse reference genomes and nucleotide versus protein databases.
DLG2 - novel candidate genes validated in a large case-control sample of schizophrenia.
The PDZ1 domain of PSD-93 might accept peptides with larger residues at the C-terminus than that of PSD-95 (zeige DLG4 Antikörper), for example the GluD2 (zeige GLUD2 Antikörper) C-terminal Ile versus the Val found at the C-terminus of NMDA receptors.
This study showed that DLG2 is related the complex learning.
Comparison of the structures of the binding cleft of PSD-93 PDZ1 with the previously reported structures of PSD-93 PDZ2 and PDZ3 as well as of the closely related human PSD-95 (zeige DLG4 Antikörper) PDZ1 shows that they are very similar in terms of amino-acid composition
Variation at the DLG2 locus contributes to maintenance of glucose homeostasis through regulation of insulin (zeige INS Antikörper) sensitivity and beta-cell function.
Coexpression of Kir2.1 (zeige KCNJ2 Antikörper) and PSD (zeige PSD Antikörper)-93delta had no discernible effect upon channel kinetics but resulted in cell surface Kir2.1 (zeige KCNJ2 Antikörper) clustering and suppression of channel internalization.
identifies new isoform of DLG2 gene, which contains 3'-end exons of the known DLG2 gene along with the hypothetical gene FLJ37266; new isoform is specifically upregulated in renal oncocytoma
This study demonstrated that in Chronic social defeat stress leads to changes PSD-93 in hippocampus of young mice.
New DLG2 gene models for human and mouse. The work brings evidence for the lack of cross-annotation in human versus mouse reference genomes and nucleotide versus protein databases.
PSD-93 knockout led to downregulation of Cox-2 (zeige COX2 Antikörper) and iNOS (zeige NOS2 Antikörper) expression, and increase in the mRNA levels of IL-10 (zeige IL10 Antikörper) following ischemic brain injury.
This study identified four proteins SynGAP (zeige SYNGAP1 Antikörper), Syntaxin-1A (zeige STX1A Antikörper), VDLC, and PKCbeta differentially expressed between PSD-93 KO and WT mice 4 h after tMCAO
Downregulation of nAChR (zeige CHRNA4 Antikörper) subunit and PSD-93 expression after cavernous nerve injury, or even manipulation, could interrupt synaptic transmission within the MPG (zeige MPG Antikörper) and thus contribute to the loss of neural control of urogenital organs after pelvic surgeries.
Membrane-associated guanylate kinase (zeige GUK1 Antikörper) homolog PSD-93 is a central organizer of the postsynaptic density at excitatory synapses on pyramidal neurons.
These data show critical roles for psd-93 and interactions with NMDA receptor subunits in organizing the differential expression in rafts and postsynaptic densities of synaptic signaling complexes.
Since NMDARs, Ca(2 (zeige CA2 Antikörper)+), and NO play a critical role during the development of brain trauma, seizures, and ischemia, the present work suggests that PSD-93 might contribute to molecular mechanisms of neuronal damage in these brain disorders.
PSD-93 deficiency in knock-out mice results in a decrease in the minimum alveolar anesthetic concentration of halothane (zeige RYR1 Antikörper).
PSD-93 serves as a membrane-anchored substrate of Fyn (zeige FYN Antikörper) and plays a role in the regulation of Fyn (zeige FYN Antikörper)-mediated modification of NMDA receptor function
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known.
, disks large homolog 2
, postsynaptic density protein 93
, channel-associated protein of synapse-110
, channel-associated protein of synapses, 110kDa
, discs, large homolog 2, chapsyn-110
, postsynaptic density protein PSD-93
, protein phosphatase 1, regulatory subunit 58
, discs large homolog 2
, synaptic density protein PSD-93