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The product of DLGAP2 is one of the membrane-associated guanylate kinases localized at postsynaptic density in neuronal cells.
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Human Polyclonal DLGAP2 Primary Antibody für IHC, ELISA - ABIN1003104
Takeuchi, Hata, Hirao, Toyoda, Irie, Takai: SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. in The Journal of biological chemistry 1997
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Results show that RP11-397D12.4, AC007403.1, and ERICH1-AS1 LncRNA expression are up-regulated in non-small-cell lung cancer (NSCLC) and may be potential biomarkers for predicting the tumorigenesis of NSCLC in the future.
The Gene-based analyses revealed four significant associations in the WT1 (zeige WT1 Antikörper), ZC3H12C (zeige ZC3H12C Antikörper), DLGAP2, and GPR1 (zeige GPR1 Antikörper) genes at p < 0.05. in this study.
DLGAP2 is a susceptible gene of schizophrenia.
this study demonistrated that two SNPs in DLGAP2 (rs6558484 and rs7014992) and prefrontal cortex white matter volume.
DLGAP2 gene is imprinted, with preferential expression from the paternal allele in testis.
Increased expression of PSD-25 and its coassembly with NMDA-receptor subunits NR1 and MR2B in resected epileptic cortical tissue suggest a possible functional role of the complex in in situ epileptogenicity of focal cortical dysplasia.
Semi-quantitative analysis of RNA levels in FMRP (zeige FMR1 Antikörper) immunoprecipitates showed that in the mouse brain mRNAs encoding PSD (zeige PSD Antikörper) components, such as Shank1 (zeige SHANK1 Antikörper), SAPAP1 (zeige DLGAP1 Antikörper)-3, PSD-95 (zeige DLG4 Antikörper), and the glutamate (zeige GRIN1 Antikörper) receptor subunits NR1 (zeige GRIN1 Antikörper) and NR2B (zeige GRIN2B Antikörper), are associated with FMRP (zeige FMR1 Antikörper).
The product of this gene is a membrane-associated guanylate kinase. The encoded protein may play a role in synapse organization and signalling in neuronal cells. This gene is biallelically expressed in the brain, however, only the paternal allele is expressed in the testis (PMID:18055845). Alternatively spliced transcript variants encoding different isoforms have been identified.
discs, large (Drosophila) homolog-associated protein 2
, discs large-associated protein 2
, Disks large-associated protein 2-like
, disks large-associated protein 2-like
, PSD-95/SAP90-associated protein-2
, PSD-95/SAP90-binding protein 2
, SAP90/PSD-95-associated protein 2
, discs large homolog-associated protein 2
, disks large-associated protein 2
, postsynaptic density 95
, SAP90/PSD-95 associated protein 2