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may mediate vascular cell growth.
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Human Polyclonal DCBLD2 Primary Antibody für IHC, IHC (p) - ABIN4304485
Fukumoto, Kinoshita, Hanazawa, Kikkawa, Chiyomaru, Enokida, Yamamoto, Goto, Nishikawa, Nakagawa, Okamoto, Seki: Identification of tumour suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature. in British journal of cancer 2014
Knockdown of the Esdn homolog (dcbld2) in zebrafish impaired normal vascular development.
Dynamic multi-site phosphorylation by Fyn (zeige FYN Antikörper) and Abl (zeige ABL1 Antikörper) drives the interaction between CRKL (zeige CRKL Antikörper) and the novel scaffolding receptors DCBLD1 and DCBLD2.
DCBLD2 protein expression profiles were compared between 11 invasive and non-invasive myxofibrosarcomas. Higher DCBLD2 expression was significantly associated with invasive properties of tumor cells. The expression level of DCBLD2 was consistent in different portions of tumor tissues.
phosphorylation of DCBLD2 Y750 recruited TRAF6 (zeige TRAF6 Antikörper), leading to increased TRAF6 (zeige TRAF6 Antikörper) E3 ubiquitin ligase (zeige MUL1 Antikörper) activity and subsequent activation of AKT (zeige AKT1 Antikörper), thereby enhancing EGFR (zeige EGFR Antikörper)-driven tumorigenesis
ESDN associates with VEGFR-2 and regulates its complex formation with negative regulators of VEGF signaling, protein tyrosine phosphatases PTP1B and TC-PTP, and VE-cadherin.
SFK activity was shown to be sufficient, but not required for the interaction between ESDN and the CrkL-SH2 domain
ESDN and AP-2g (zeige TFAP2C Antikörper) expression is lower in thick melanomas, it is associated with unfavourable histo-pathological parameters (increased vascularity, vascular invasion and mitoses) and correlates with a shorter DFS (zeige FST Antikörper) like for AP-2a.
These findings suggest that DCBLD2 could be a potential marker and drug target for treatment of nasal polyposis in Korean asthma patients.
Seven SNPs (rs1371687, rs7615856, rs828621, rs828618, rs828616, rs1062196, and rs8833) and one haplotype (DCBLD2-ht1) show associations with susceptibility to AERD.
The full-length signal peptides of DCBLD2 is functional and furthermore that the C-domains are sufficient and essential for ER targeting, whereas the N-domains are dispensable. Thus, the N-domains are available for additional functions.
our study is the first to identify and validate Endofin (zeige ZFYVE16 Antikörper), DCBLD2, and KIAA0582 as part of a complex EGF (zeige EGF Antikörper) phosphotyrosine signaling network
ESDN regulates insulin (zeige INS Antikörper) signaling and subsequently a wide array of insulin (zeige INS Antikörper) effects in cultured cells and in vivo through modulation of IR interaction with APS (zeige SH2B2 Antikörper) and Grb10 (zeige GRB10 Antikörper).
Deletion of Esdn in the mouse interfered with adult and developmental angiogenesis.
may mediate vascular cell growth
discoidin, CUB and LCCL domain containing 2
, discoidin, CUB and LCCL domain-containing protein 2-like
, CUB, LCCL and coagulation factor V/VIII-homology domains protein 1
, coagulation factor V/VIII-homology domains protein 1
, discoidin, CUB and LCCL domain-containing protein 2
, endothelial and smooth muscle cell-derived neuropilin-like protein