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DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen DEF6 Antikörper (68) und viele weitere Produktgruppen zu diesem Protein an.
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Swap70b and Def6a delineate Wnt11 (zeige WNT11 Proteine) and Wnt5b (zeige WNT5B Proteine) signalling pathways and have roles in convergent and extension cell movement during zebrafish gastrulation
def6 morphants phenocopy Wnt5b (zeige WNT5B Proteine) mutants and ectopic overexpression of def6 essentially rescues Wnt5b (zeige WNT5B Proteine) morphants, indicating a novel role for def6 as a central GEF (zeige SLC2A4RG Proteine) downstream of Wnt5b (zeige WNT5B Proteine) signaling
Studies indicate that the autoimmune phenotype in DEF6 and SWAP-70 knock-out (DKO) mice is characterized by the accumulation of B cell subset that expresses high levels of CD11c and T-bet (ABCs).
DEF6 and SWAP70 (zeige SWAP70 Proteine) are SWEF proteins with important contributors to hematopoietic stem and precursor cells biology
this study identifies Def6 as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions
These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling.
SLAT is an IP3R1 (zeige ITPR1 Proteine)-interacting protein required for T cell activation.
PKClambda/iota was identified as an important factor for actin cytoskeletal regulation in podocytes and Def-6 as a specific downstream target of PKClambda/iota that regulates the activity of small GTPases and subsequently the actin cytoskeleton of podocytes.
Data suggest that SLAT acts as a negative modulator of RANKL (zeige TNFSF11 Proteine)-induced osteoclastogenesis.
SLAT-mediated nuclear factor of activated T-cell (zeige NFATC3 Proteine) (NFAT)1 (zeige NFAT1 Proteine) activation is required for efficient expansion of CD8 (zeige CD8A Proteine)+ T cells during the primary response but is not necessary for cytotoxic T lymphocyte (CTL) differentiation.
SLAT/Def6 plays a major role in the T cell-mediated autoimmune processes that bring about the inflammatory eye disease, experimental autoimmune uveitis.
plays a role in Th2 development and/or activation, perhaps by interfering with ZAP-70 (zeige ZAP70 Proteine) signaling
this study identifies Def6 (zeige DEFA6 Proteine) as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions
DEF6 expression may serve as an independent prognostic factor, and interacted positively with p16 toward high tumor stage and shorter survival.
IBP (zeige TSPO Proteine) was expressed ectopically in someoral squamous cell carcinoma samples and correlated significantly with tumor size, differentiation, clinical stage and distant metastases
DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies.
Molecular cloning of IBP (zeige TSPO Proteine), a guanine nucleotide exchange factor (zeige RASGRF1 Proteine), which is highly expressed in the immune system.
IBP (zeige TSPO Proteine) is a novel guanine nucleotide exchange factor (zeige RASGRF1 Proteine) and is recruited to the immunological synapse by T cell receptor engagement
DEF6 not only activates Rho-family GTPases but also cooperates with activated Rac1 to exert its cellular function
Overexpression of the Interferon regulatory factor 4 (zeige IRF4 Proteine)-binding protein is associated with Colorectal Carcinoma.
DEF6 (zeige DEFA6 Proteine), a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42 (zeige CDC42 Proteine), and RhoA (zeige RHOA Proteine).
DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003
differentially expressed in FDCP 6 homolog (mouse)
, differentially expressed in FDCP 6 homolog
, IRF-4-binding protein
, IRF4-binding protein
, SWAP-70-like adapter of T-cells
, SWAP-70-like adaptor protein of T cells