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DNASE1 encodes a member of the DNase family.
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Human DNASE1 ELISA Kit für Sandwich ELISA - ABIN414564
Dhondup, Ueland, Dahl, Askevold, Sandanger, Fiane, Ohm, Sjaastad, Finsen, Wæhre, Gullestad, Aukrust, Yndestad, Vinge: Low Circulating Levels of Mitochondrial and High Levels of Nuclear DNA Predict Mortality in Chronic Heart Failure. in Journal of cardiac failure 2016
Genetic variants in DNase I hypersensitive sites play an important role in carcinogenesis. two novel single nucleotide polymorphisms rs12309362 (odds ratio = 0.64, P = 5.61 x 10(-6) ) and rs9970827 (odds ratio = 0.73, P = 7.23 x 10(-6) ) significantly associated with decreased risk of HCC.
Serum DNase1-activity is significantly decreased in ALD (zeige ABCD1 ELISA Kits) patients, indicating its potential implication in their pathogenesis. Furthermore, DNase1-activity could be used as a new surrogate biomarker for predicting response to AIH treatment.
Although no significant association between Q222R polymorphism in DNAse I gene and the risk of systemic lupus erythematosus was found, the presence of the A allele was associated with an increased risk for the development of nephropathy
DNase I activity was observed to be increased in type 2 diabetes, and high glucose combined with increased DNase I is suggested to aggravate beta-cell apoptosis.
Single nucleotide polymorphisms producing a loss-of-function variant of the enzymes in DNASE1, DNASE1L3, and DNASE2, possibly serving as a genetic risk factor for autoimmune diseases, were confirmed.
TNF-alpha (zeige TNF ELISA Kits) amplifies DNaseI expression in renal tubular cells while IL-1beta (zeige IL1B ELISA Kits) promotes nuclear DNaseI translocation in inactive form in lupus nephritis.
HumDN1 polymorphisms were examined in blood of 11 worldwide populations by polymerase chain reaction. 15 genotypes were found leading to the conclusion that HumDN1 variable no. tandem repeats are ethnic group specific.
Val66Met in the BDNF (zeige BDNF ELISA Kits) gene and two SNPs, Fokl and Apal, in the VDR (zeige CYP27B1 ELISA Kits) gene may potentially be associated with DED (zeige AATF ELISA Kits). Additionally, the association between DED (zeige AATF ELISA Kits) and Val66Met may vary by depression status.
In conclusion, elevated DNase I in diabetes may be related to pancreatic injury and could be one of the causes that induce diabetes.
Our results indicate that increased DNASE1 expression is common to both SLE and RA, while DNase1 reduction activity is specific to SLE.
DNase1 and DNase1-like 3 are independently expressed and thus provide dual host protection against deleterious effects of intravascular neutrophil extracellular traps.
HMGN1 (zeige HMGN1 ELISA Kits) binds to CpG island-containing promoters and affects the organization of nucleosomes, DNase I hypersensitivity, and the transcriptional profile of mouse embryonic stem cells and neural progenitors.
Early mesangial nephritis initiates a cascade of inflammatory signals that lead to up-regulation of Trap1 (zeige TRAP1 ELISA Kits) and a consequent down-regulation of renal DNaseI by transcriptional interference.
silencing of renal DNaseI gene expression initiates a cascade of inflammatory signals including activation of Toll (zeige TLR4 ELISA Kits) like receptors and Clec4e (zeige CLEC4E ELISA Kits), leading to progression of both murine and human lupus nephritis
Data show that deletion of DNaseI hypersensitive sites does not have an obvious impact on the IgH locus or B cell development.
Reduction in renal Dnase1 expression and activity is limited to mice and SLE patients with signs of membranoproliferative nephritis, and may be a critical event in the development of severe forms of lupus nephritis.
A conserved sequence located 211 kilobases upstream of class II major histocompatibility complex transcriptional coactivator (CIITA) promoter III is hypersensitive to DNase I.
The impact of antibodies to dsDNA, renal Dnase1 and matrix metalloprotease (MMP) mRNA levels and enzyme activities on early and late events in murine lupus nephritis, was determined.
serum Dnase1 in cooperation with the plasminogen (zeige PLG ELISA Kits) system guarantees a fast and effective breakdown of chromatin during necrosis by the combined cleavage of DNA as well as of DNA binding proteins.
DNase I is essential for kidney injury induced by cisplatin
ascorbic acid has the ability to inhibit DNase I, one of the main endonucleases involved in DNA fragmentation during apoptosis.
the practical capability of this assay system was successfully demonstrated by its use to determine DNase I activity in bovine urine.
Specificity in DNA-DNase I interaction is mediated by DNA flexibility, which influences the induced-fit transitions required to form productive complexes.
Purification and characterization of equine DNase 1 was done; it was confirmed to be of the parotid-type.
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
, DNase I, lysosomal
, Dornase alfa
, human urine deoxyribonuclease I
, deoxyribonuclease I
, Deoxyribonuclease I