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Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Zusätzlich bieten wir Ihnen beta Defensin 1 Antikörper (168) und beta Defensin 1 Kits (50) und viele weitere Produktgruppen zu diesem Protein an.
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identification of critical promoter regions of DEFB1 that are epigenetically influenced by lactobacilli in vaginal keratinocytes
Endometrial tissues and epithelial cells constitutively secreted both BD-1 and -2 mostly at the apical compartment. Both genistein and daidzein induced BDs secretion which reached a peak at 5-15 min. The apical secretion of BDs was coincidence with increased Cl- secretion induced by genistein.
The polymorphisms in DEFB1 were not associated with hBD (zeige HBd Proteine) salivary level and caries experience (p > 0.05) in children.
These findings suggest a role for hBD-1 in psoriasis pathogenesis
Significant associations were found between periodontitis and g. -20G> A (rs11362) and g. -44C> G (rs1800972) SNPs in DEFB1 gene as well as p.Ala29Thr (rs1126477) and p.Lys47Arg (rs1126478) SNPs in LTF (zeige LTF Proteine) gene.
hBD-1 potentiates the induction of in vitro osteoclastogenesis by RANKL via enhanced phosphorylation of the p44/42 MAPKs.
findings lead us to hypothesize an involvement of hBD-1 mediated innate immunity in the modulation of the susceptibility towards adeno (zeige ADORA2A Proteine)-tonsillar hypertrophy development.
Two DEFB1 SNPs were significantly associated with the DMFT(decayed, missing, filled teeth) index.
Multivariate logistic regression analysis showed that hBD-1 basal cell loss (>/=20% of prostatic glands in total cores) is an independent factor for predicting prostatic adenocarcinoma (odds ratio: 4.739, confidence interval: 1.093-20.554, p = 0.038). hBD-1 loss of basal cells is a useful indicator to identify extremely high-risk patients with initially negative biopsy.
It was concluded that bile acids can differentially regulate colonic epithelial beta-defensin expression and secretion; the authors discuss the implications for intestinal health and disease.-
Fenofibrate and gemfibrozil inhibit LPS (zeige TLR4 Proteine)-induced inflammatory activation of macrophages via PPARalpha (zeige PPARA Proteine)/beta-defensin 1/TLR4 (zeige TLR4 Proteine) pathway.
these studies demonstrate a role for the murine beta-defensin 1 peptide in early control of Candida infection in a murine model of mucosal candidiasis
Akt1 (zeige AKT1 Proteine) is involved in the regulation of defensin (zeige DEF Proteine) expression and the innate immune response important for bacterial clearance
Histopathology showed a greater inflammatory influx in the lungs of mBD-1((-/-)) mice at Day 3 postinfection compared with WT C57BL/6 mice
The decreased production of antimicrobial peptides by burn-site epidermal keratinocytes influenced by Gr-1 (zeige GSR Proteine)(+)CD11b (zeige ITGAM Proteine)(+) cells was shown to be restored by glycyrrhizin.
elimination of mBD-1 results in a defect in the ability of the host to clear H. influenzae from the lung, which is most consistent with this peptide functioning as an antibiotic at the airway surface.
The expression of BD1 was significantly elevated in the lungs of cigarette smoke-exposed mice compared with air-exposed mice.
Although both murine beta-defensin (mBD)-1 and mBD2 (zeige MBD2 Proteine) are constitutively expressed in normal BALB/c and C57BL/6 corneas, mBD-1 is not required for host resistance against Pseudomonas aeruginosa-induced corneal infection.
pBD1 showed low hemolytic activity and high thermal stability. These properties are relevant for the biotechnological applications of the peptide.
Zinc sulfate and L-isoleucine induce beta defensin expression in a porcine cell line.
Presence of beta-defensin 1 in the upper respiratory tract is associated with resistance against respiratory infection with Bordetella pertussis in older piglets
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis.
, beta-defensin 1
, Gal 1
, Gal 1-alpha
, antimicrobial peptide 1
, antimicrobial peptide CHP2
, chicken heterophil peptide 2
, gal-1 alpha
, gallinacin-1 alpha
, beta defensin-1 homolog
, prepro-beta-defensin 1
, Beta-defensin 1
, Defensin, beta 1
, DEFB1-like protein
, beta defensin 1