anti-DNA-Damage Regulated Autophagy Modulator 1 (DRAM1) Antikörper

Human DNA-Damage Regulated Autophagy Modulator 1 (DRAM1) Interaktionspartner

1. DRAM1 regulates apoptosis by inhibiting BAX (zeige BAX Antikörper) degradation.

2. DRAM1 mediates autophagic defense against a broader range of intracellular pathogens, since DRAM1 expression was also induced by the common bacterial endotoxin lipopolysaccharide.

3. Suggest that promoting DRAM-mediated autophagy together with PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) inhibition might be more effective for autophagy-based therapy in hepatoma.

4. DRAM is an important gene for the enhancement of p53 (zeige TP53 Antikörper)-dependent apoptosis.

5. DRAM1 affects autophagy through lysosomal acidification, fusion of lysosomes with autophagosomes and clearance of autophagosomes.

6. DRAM gene expression is down regulated by oxidative stress through the mediation of reactive oxygen species

7. DRAM triggers lysosomal membrane permeabilization and cell death in CD4 (zeige CD4 Antikörper)(+) T cells infected with HIV.

8. these findings shed new light on the role of autophagy in GBM and reveal a novel function of the autophagy regulators DRAM1 and p62 in control of migration/invasion in cancer stem cells.

9. Overexpression of miR (zeige MLXIP Antikörper)-199a-5p inhibits DRAM1 and Beclin1 (zeige BECN1 Antikörper) expression.

10. p73 (zeige TP73 Antikörper)-regulated DRAM-1 is functionally involved in neutrophil differentiation of acute promyelocytic leukemia (zeige PML Antikörper) cells.

Mouse (Murine) DNA-Damage Regulated Autophagy Modulator 1 (DRAM1) Interaktionspartner

1. DRAM1 knockdown aggravates OGD (zeige FGFR1 Antikörper)/R-induced cell injury.

2. DRAM-1 encodes not just one mRNA, but a series of p53 (zeige TP53 Antikörper)-inducible splice variants which are expressed at varying levels in multiple human and mouse cell lines.