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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Zusätzlich bieten wir Ihnen DNMT3B Antikörper (133) und DNMT3B Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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dnmt7 specifically methylates no tail gene in the genome
Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (zeige HELLS ELISA Kits) content are rather a function of time, and not a genetic component.
DNMT1 (zeige DNMT1 ELISA Kits), DNMT3A (zeige DNMT3A ELISA Kits), and DNMT3B were overexpressed in 36.9, 26, and 23 % of the OSCC patients, respectively. DNMT1 (zeige DNMT1 ELISA Kits) overexpression was significantly associated with the overall survival, p = 0.029, and relapse-free survival of OSCC patients, p = 0.003. Patients with DNMT1 (zeige DNMT1 ELISA Kits) overexpression, as an independent prognostic factor, had a 2.385 times higher risk to relapse than those with lower expression. The DNMT1 (zeige DNMT1 ELISA Kits) A201G gene polymorphi
report the first crystal structure of the DNMT3B PWWP domain-H3K36me3 complex.
Results continue to establish ANG (zeige ANG ELISA Kits) as an oncoprotein and further reveal that ANG (zeige ANG ELISA Kits) contributes to oncogenesis by the activation of MMP2 (zeige MMP2 ELISA Kits) through modulation of DNMT3b functions.
found association between DNMT3B rs2424913 in T allele carriers with Parkinson's disease
H19 (zeige NCKAP1 ELISA Kits) might function as ceRNA (competing endogenous RNA) for miR (zeige MLXIP ELISA Kits)-29b-3p and relieve the suppression for DNMT3B, which led to EMT (zeige ITK ELISA Kits) and metastasis of bladder cancer (BC). Our findings highlight a novel mechanism of H19 (zeige NCKAP1 ELISA Kits) in progression of BC and provide H19 (zeige NCKAP1 ELISA Kits)/miR (zeige MLXIP ELISA Kits)-29b-3p/DNMT3B axis as a promising therapeutic target for BC.
DNMT1 (zeige DNMT1 ELISA Kits) up-regulation induced by IL-6 (zeige IL6 ELISA Kits)/STAT3 (zeige STAT3 ELISA Kits) signaling was indispensable for IL-6 (zeige IL6 ELISA Kits)-mediated hepaCAM (zeige HEPACAM ELISA Kits) loss in renal cell carcinoma (RCC (zeige XRCC1 ELISA Kits)) cell lines ACHN and 769-P, while DNMT3b up-regulation was crucial for hepaCAM (zeige HEPACAM ELISA Kits) loss in A498.
A Methylated DNA Quantification Kit was used to quantify global DNA methylation (zeige HELLS ELISA Kits), and single nucleotide polymorphisms (SNPs) in DNMT3A (zeige DNMT3A ELISA Kits) (rs36012910, rs1550117, and R882) and DNMT3B (rs1569686, rs2424909, and rs2424913) were identified using the restriction fragment length polymorphism method
A novel homozygous missense mutation, Ala585Thr, was found in DNMT3B.
Definitive diagnosis should be done using metaphase analysis to identify centromeric instability and/or ICF disease gene mutations analysis. Bilateral VUR may occur in ICF patients with homozygous DNMT3B mutations in early childhood. Renal ultrasonography should be included in ICF1 patients for the screening of congenital anomalies.
DNMT 3B was upregulated in invasive subclones and exerted on influence of E-cad gene methylation.
The epiblast expressed epithelial markers, MUC1 (zeige MUC1 ELISA Kits) and E-CADHERIN (zeige CDH1 ELISA Kits), and the pluripotency markers, DNMT3B and CRIPTO (zeige TDGF1 ELISA Kits).
Developmental changes in expression of DNMT3B are indicative of a possible role in changes in methylation in cattle.
The expression levels of DNMT3a (zeige DNMT3A ELISA Kits) and DNMT3b were associated with several beef quality traits.
a new paradigm of transcriptional regulation critical for cardiac development and maturation that is controlled by the interaction of REST, DNMT3B and non-CpG methylation.
Together, this study described the regulation of Chk2 (zeige CHEK2 ELISA Kits) expression through promoter methylation by Dnmt3b and also presented a novel role of Chk2 (zeige CHEK2 ELISA Kits) during neuronal differentiation, which is independent of its previously known function in DNA damage response.
in mouse embryonic stem cells, Dnmt3b-dependent intragenic DNA methylation protects the gene body from spurious RNA polymerase II entry and cryptic transcription initiation
three DNA methyltransferases, Dnmt1 (zeige DNMT1 ELISA Kits), Dnmt3a (zeige DNMT3A ELISA Kits), and Dnmt3b, have been identified. Dnmt3a (zeige DNMT3A ELISA Kits) and Dnmt3b are responsible for establishing DNA methylation (zeige HELLS ELISA Kits) patterns produced through their de novo-type DNA methylation (zeige HELLS ELISA Kits) activity in implantation stage embryos and during germ cell differentiation. Dnmt3-like (Dnmt3l (zeige TRDMT1 ELISA Kits)), which is a member of the Dnmt3 family but does not possess DNA methylation (zeige HELLS ELISA Kits)
While lens epithelial cell survival requires DNMT1 (zeige DNMT1 ELISA Kits), morphologically normal lenses develop in the absence of both DNMT3A (zeige DNMT3A ELISA Kits) and DNMT3B.
Mechanical stimulation regulates osteoblastic genes expression via direct regulation of Dnmt3b.
a miR (zeige MLXIP ELISA Kits)-125b-DNMT3b-p53 (zeige TP53 ELISA Kits) signal pathway may exist in the vascular smooth muscle cells proliferation induced by homocysteine.
miR (zeige MLXIP ELISA Kits)-29a mimic transfection lowered collagen 1alpha1, DNMT1 (zeige DNMT1 ELISA Kits), DNMT3b and SET1A (zeige SETD1A ELISA Kits) expression in hepatic stellate cells.
Loss of DNMT3B results in hypomethylation of the miR (zeige MLXIP ELISA Kits)-196b promoter and increased miR (zeige MLXIP ELISA Kits)-196b expression, which directly targets the mTORC2 (zeige CRTC2 ELISA Kits) component Rictor (zeige RICTOR ELISA Kits).
The findings define PRMT7 (zeige PRMT7 ELISA Kits) as a regulator of the DNMT3b/p21 axis required to maintain muscle stem cell regenerative capacity.
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
DNA (cytosine-5)-methyltransferase 3B
, DNA (cytosine-5-)-methyltransferase 3 beta
, DNA cytosine-5 methyltransferase 3 beta
, DNA (cytosine-5)-methyltransferase 3B-like
, DNA methyl transferase beta
, DNA methyltransferase 3B
, DNA MTase HsaIIIB
, DNA methyltransferase HsaIIIB
, DNA (cytosine-5-)-methyltransferase 3 beta, like
, DNA (cytosine-5-)-methyltransferase 7
, DNA MTase MmuIIIB
, DNA methyltransferase MmuIIIB