DNA (Cytosine-5-)-Methyltransferase 3 alpha Proteine (DNMT3A)

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Zusätzlich bieten wir Ihnen DNMT3A Antikörper (268) und DNMT3A Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
DNMT3A 1788 Q9Y6K1
Ratte DNMT3A DNMT3A 444984 Q1LZ53
DNMT3A 13435 O88508
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Showing 5 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Bioactivity measured with Activity Assay Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage

DNMT3A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine)

Am meisten referenzierte DNMT3A Proteine

  1. Human DNMT3A Protein expressed in HEK-293 Cells - ABIN2719617 : Cree, Fredericks, Miller, Pearce, Filichev, Fee, Kennedy: DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro. in FEBS letters 2016 (PubMed)

Weitere Proteine zu DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartnern

Pig (Porcine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (zeige DNMT1 Proteine), Dnmt3a, Hdac1 (zeige HDAC1 Proteine), Kdm3a (zeige KDM3A Proteine) and Uhrf1 (zeige UHRF1 Proteine) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

Human DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. Our results provided novel insight into the role of the DNMT3A R882H mutation in AML (zeige RUNX1 Proteine) pathogenesis and suggested that targeting the cellular GSH synthetic pathway could enhance the current therapy for AML (zeige RUNX1 Proteine) patients with the DNMT3A R882H mutation.

  2. data confirm MLL (zeige MLL Proteine)-PTD (zeige BCS1L Proteine) and, to a lesser extent, FLT3 (zeige FLT3 Proteine)-ITD as common events in +11 AML (zeige RUNX1 Proteine).6, 7, 8 However, the high mutation frequencies of U2AF1 (zeige U2AF1 Proteine) and genes involved in methylation (DNMT3A, IDH2 (zeige IDH2 Proteine)) have hitherto not been reported in +11 AML (zeige RUNX1 Proteine)

  3. Silencing DNMT3A inhibits proliferation and invasion in ESCC cells by inducing demethylation of DOK7 (zeige DOK7 Proteine).

  4. Data show that DNA methyltransferase 3A (DNMT3A) mutation was significantly associated with adverse outcome in addition to conventional risk stratification.

  5. DNMT3A polymorphisms may be potential predictive markers for acute myelogenous leukemia patients' outcomes in China

  6. this study shows that DNMT3A mutations are present in a significant proportion of SF3B1mut patients with RARS (zeige RARS Proteine) and its presence has a clearly negative impact on outcomes, determining a higher RBC (zeige CACNA1C Proteine) transfusion dependency, higher risk of progression to AML (zeige RUNX1 Proteine), and lower OS.

  7. DNMT1 (zeige DNMT1 Proteine), DNMT3A, and DNMT3B (zeige DNMT3B Proteine) were overexpressed in 36.9, 26, and 23 % of the OSCC patients, respectively. DNMT1 (zeige DNMT1 Proteine) overexpression was significantly associated with the overall survival, p = 0.029, and relapse-free survival of OSCC patients, p = 0.003. Patients with DNMT1 (zeige DNMT1 Proteine) overexpression, as an independent prognostic factor, had a 2.385 times higher risk to relapse than those with lower expression. The DNMT1 (zeige DNMT1 Proteine) A201G gene polymorphi

  8. genetic variations in STX1B (zeige STX1B Proteine), DNMT3A and CYP1A1 (zeige CYP1A1 Proteine) have roles in influencing warfarin maintenance dose

  9. DNMT3A is a de novo DNA methyltransferase (zeige DNMT1 Proteine) that has recently gained relevance because of its frequent mutation in a large variety of immature and mature hematologic neoplasms. DNMT3A mutations are early events during cancer development and seem to confer poor prognosis to acute myeloid leukemia (zeige BCL11A Proteine) patients making this gene an attractive target for new therapies. [review]

  10. the present cohort study demonstrated that FLT3 (zeige FLT3 Proteine)-ITD and DNMT3A R882 double mutation predicts poor prognosis in Chinese AML (zeige RUNX1 Proteine) patients receiving chemotherapy or allo-HSCT treatment.

Horse (Equine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (zeige HELLS Proteine) content are rather a function of time, and not a genetic component.

Cow (Bovine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. The effect of p53 (zeige TP53 Proteine) expression on the development of cloned embryos, and its interaction with HDAC1 (zeige HDAC1 Proteine) and DNMT3A are reported.

  2. The expression levels of DNMT3a and DNMT3b (zeige DNMT3B Proteine) were associated with several beef quality traits.

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. These data suggest that DNMT3a is required for nerve injury-induced and MBD1 (zeige DPEP1 Proteine)-mediated epigenetic silencing of the MOR (zeige OPRM1 Proteine) and KOR (zeige OPRK1 Proteine) in the injured DRG. DNMT3a inhibition may serve as a promising adjuvant therapy for opioid use in neuropathic pain management.

  2. Data show that conditional deletion of Dnmt3a and simultaneous "knock in" of Flt3ITD/+, cooperate to drive leukemia development at a faster rate than Dnmt3a loss alone.

  3. Deletion of DNMT3a in postnatal forebrain neurons does no alter affective behavior.

  4. Altogether, the authors demonstrate that Dnmt3a and Dnmt3b (zeige DNMT3B Proteine) protect the epidermis from tumorigenesis and that squamous carcinomas are sensitive to inhibition of PPAR-gamma (zeige PPARG Proteine).

  5. Upon lysolecithin injection in the spinal cord of transgenic mice, study detected defective oligodendrocyte progenitor cells differentiation and inefficient remyelination in the DNA methyltransferase 3a null and DNA methyltransferase 1/DNA methyltransferase (zeige DNMT1 Proteine) 3a null mice.

  6. This is attributed in part to ineffective repression of Tcf1 (zeige HNF1A Proteine) expression in knockout T cells, as DNMT3a localizes to the Tcf7 (zeige TCF7 Proteine) promoter and catalyzes its de novo methylation in early effector WT CD8 (zeige CD8A Proteine)(+) T cells. These data identify DNMT3a as a crucial regulator of CD8 (zeige CD8A Proteine)(+) early effector cell differentiation and effector versus memory fate decisions.

  7. Compared the activity of individual DNMT3A isoforms in embryonic stem and neuronal progenitor cells and report that these isoforms differ in their genomic binding and DNA methylation (zeige HELLS Proteine) activity at regulatory sites. We identify that the longer isoform DNMT3A1 preferentially localizes to the methylated shores of bivalent CpG island promoters in a tissue-specific manner.

  8. Study shows that in the mouse brain during early life, the DNA methyltransferase (zeige DNMT1 Proteine) DNMT3A preferentially binds transiently to intergenic regions and across transcribed regions of lowly expressed genes and that this binding primarily determines the pattern of DNA methylation (zeige HELLS Proteine) at CA sequences in the adult brain.

  9. conditional inactivation of Dnmt3a in mouse hematopoietic cells leads to an accumulation of immature progenitors in the thymus, which are less apoptotic. These data demonstrate that Dnmt3a is required for normal T-cell development, and acts as a T-ALL tumor suppressor

  10. These data demonstrate that haploinsufficiency for Dnmt3a alters hematopoiesis and predisposes mice (and probably humans) to myeloid malignancies by a mechanism that is not yet clear.

DNMT3A Protein Überblick

Protein Überblick

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit DNMT3A

  • DNA methyltransferase 3 alpha (DNMT3A)
  • DNA methyltransferase 3 alpha (dnmt3a)
  • DNA methyltransferase 3 alpha (Dnmt3a)
  • DNA methyltransferase 3A (Dnmt3a)
  • DNMT3A Protein
  • DNMT3A2 Protein
  • M.HsaIIIA Protein
  • MmuIIIA Protein

Bezeichner auf Proteinebene für DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha , DNA cytosine methyltransferase 3 alpha , DNA (cytosine-5)-methyltransferase 3A , DNA methyl transferase alpha , DNA methyltransferase 3A , DNA MTase HsaIIIA , DNA cytosine methyltransferase 3A2 , DNA-methyltransferase 3a , DNA MTase MmuIIIA , DNA methyltransferase MmuIIIA

482996 Canis lupus familiaris
694822 Macaca mulatta
739139 Pan troglodytes
100037301 Sus scrofa
100030681 Monodelphis domestica
100344715 Oryctolagus cuniculus
100500776 Ovis aries
100594618 Nomascus leucogenys
100529107 Anolis carolinensis
1788 Homo sapiens
421991 Gallus gallus
100510798 Felis catus
100055881 Equus caballus
359716 Bos taurus
444984 Rattus norvegicus
13435 Mus musculus
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