DNA (Cytosine-5-)-Methyltransferase 3 alpha Proteine (DNMT3A)

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Zusätzlich bieten wir Ihnen DNMT3A Antikörper (282) und DNMT3A Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
DNMT3A 1788 Q9Y6K1
Ratte DNMT3A DNMT3A 444984 Q1LZ53
DNMT3A 13435 O88508
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Showing 5 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Bioactivity measured with Activity Assay Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
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Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
$400.46
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DNMT3A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine)

Am meisten referenzierte DNMT3A Proteine

  1. Human DNMT3A Protein expressed in HEK-293 Cells - ABIN2719617 : Cree, Fredericks, Miller, Pearce, Filichev, Fee, Kennedy: DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro. in FEBS letters 2016 (PubMed)

Weitere Proteine zu DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartnern

Pig (Porcine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (zeige DNMT1 Proteine), Dnmt3a, Hdac1 (zeige HDAC1 Proteine), Kdm3a (zeige KDM3A Proteine) and Uhrf1 (zeige UHRF1 Proteine) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

Human DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. we found that DNMT3A was responsible for the down-regulation of miR (zeige MLXIP Proteine)-105 in gastric cancer cells

  2. Taken together, these data demonstrate that adipose Dnmt3a is a novel epigenetic mediator of insulin (zeige INS Proteine) resistance in vitro and in vivo.

  3. Low frequency of DNMT3A mutations in pediatric T-ALL is in striking contrast to adult T-ALL and renders the necessity for the search of other candidate prognostic markers. Combined Sanger sequencing-HRM approach offers a cost-effective option for genotyping DNMT3A coding sequence, with potential clinical application in other hematological malignancies.

  4. 2.65-angstrom crystal structure of the DNMT3A-DNMT3L (zeige TRDMT1 Proteine)-DNA complex in which two DNMT3A monomers simultaneously attack two cytosine-phosphate-guanine (CpG) dinucleotides, with the target sites separated by 14 base pairs within the same DNA duplex; mechanistic basis for DNMT3A-mediated DNA methylation (zeige HELLS Proteine) and establishment of its aetiological link to human disease

  5. based on the investigation of previously reported variants in patients with Tatton-Brown-Rahman syndrome , we found overlap in the spectrum of DNMT3A variants observed in this disorder and somatic variants in hematological malignancies

  6. The emodininduced downregulation of UHRF1 (zeige UHRF1 Proteine) led to an increase in the level of DNA methyltransferase 3A.

  7. Data suggest that miR (zeige MLXIP Proteine)-200b-3p may exhibit targeting and suppressive effects on DNA methyltransferase 3A (DNMT3A).

  8. Prostaglandin E2 promotes the acquisition of DNMT3A-dependent tolerogenic functions in human myeloid-derived suppressor cells.

  9. human mammary epithelial cells reprogramming is dependent on gene silencing by the DNA methyltransferase (zeige DNMT1 Proteine) DNMT3A and loss of histone transcriptional marks following downregulation of the methyltransferase DOT1L (zeige DOT1L Proteine).

  10. the immunohistochemical expressions of Klotho (zeige KL Proteine) and DNMT3a in tissues obtained from oral dysplasia and oral squamous cell carcinoma, is reported.

Horse (Equine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (zeige HELLS Proteine) content are rather a function of time, and not a genetic component.

Cow (Bovine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. The effect of p53 (zeige TP53 Proteine) expression on the development of cloned embryos, and its interaction with HDAC1 (zeige HDAC1 Proteine) and DNMT3A are reported.

  2. The expression levels of DNMT3a and DNMT3b (zeige DNMT3B Proteine) were associated with several beef quality traits.

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. individual pain vulnerability may be inherent mostly in the emotional/affective component of chronic pain and remain consistent in different aspects of negative emotion, in which adaptive changes in the function of DNA methyltransferase 3a for DNA methylation (zeige HELLS Proteine) in central amygdala may play an important role.

  2. Taken together, these data demonstrate that adipose Dnmt3a is a novel epigenetic mediator of insulin (zeige INS Proteine) resistance in vitro and in vivo.

  3. The aim of the present study is to investigate spatial and temporal expression levels and subcellular localizations of the DNMT1 (zeige DNMT1 Proteine), DNMT3A, and DNMT3B (zeige DNMT3B Proteine) proteins in the mouse germinal vesicle (GV) and metaphase II (MII) oocytes, and early embryos from 1-cell to blastocyst stages.

  4. our Dnmt3a R878H mice have shown that leukemic cells have altered gene expression and epigenetic regulatory patterns contributing to the growth/survival advantage over WT mice.The present study found that the DNMT3A mutation contributed to hypomethylation in the gene body region of mTOR (zeige FRAP1 Proteine) in Dnmt3aR878H/WT mice.

  5. Knockdown of DNMT3A or DNMT1 (zeige DNMT1 Proteine) protected neurons against mutant Htt (zeige HTT Proteine)-induced toxicity, together demonstrating a requirement for DNMTs in mutant Htt (zeige HTT Proteine)-triggered neuronal death and suggesting a neurodegenerative mechanism based on DNA methylation (zeige HELLS Proteine)-mediated transcriptional repression.

  6. Data demonstrate that DNMT3A and DNA methylation (zeige HELLS Proteine) are key modulators of mast cell responsiveness to acute and chronic stimulation.

  7. These data suggest that DNMT3a is required for nerve injury-induced and MBD1 (zeige DPEP1 Proteine)-mediated epigenetic silencing of the MOR (zeige OPRM1 Proteine) and KOR (zeige OPRK1 Proteine) in the injured DRG. DNMT3a inhibition may serve as a promising adjuvant therapy for opioid use in neuropathic pain management.

  8. Data show that conditional deletion of Dnmt3a and simultaneous "knock in" of Flt3ITD/+, cooperate to drive leukemia development at a faster rate than Dnmt3a loss alone.

  9. Deletion of DNMT3a in postnatal forebrain neurons does no alter affective behavior.

  10. Altogether, the authors demonstrate that Dnmt3a and Dnmt3b (zeige DNMT3B Proteine) protect the epidermis from tumorigenesis and that squamous carcinomas are sensitive to inhibition of PPAR-gamma (zeige PPARG Proteine).

DNMT3A Protein Überblick

Protein Überblick

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit DNMT3A

  • DNA methyltransferase 3 alpha (DNMT3A)
  • DNA methyltransferase 3 alpha (dnmt3a)
  • DNA methyltransferase 3 alpha (Dnmt3a)
  • DNA methyltransferase 3A (Dnmt3a)
  • DNMT3A Protein
  • DNMT3A2 Protein
  • M.HsaIIIA Protein
  • MmuIIIA Protein

Bezeichner auf Proteinebene für DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha , DNA cytosine methyltransferase 3 alpha , DNA (cytosine-5)-methyltransferase 3A , DNA methyl transferase alpha , DNA methyltransferase 3A , DNA MTase HsaIIIA , DNA cytosine methyltransferase 3A2 , DNA-methyltransferase 3a , DNA MTase MmuIIIA , DNA methyltransferase MmuIIIA

GENE ID SPEZIES
482996 Canis lupus familiaris
694822 Macaca mulatta
739139 Pan troglodytes
100037301 Sus scrofa
100030681 Monodelphis domestica
100344715 Oryctolagus cuniculus
100500776 Ovis aries
100594618 Nomascus leucogenys
100529107 Anolis carolinensis
1788 Homo sapiens
421991 Gallus gallus
100510798 Felis catus
100055881 Equus caballus
359716 Bos taurus
444984 Rattus norvegicus
13435 Mus musculus
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