DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) ELISA Kits

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Zusätzlich bieten wir Ihnen DNMT3A Antikörper (283) und DNMT3A Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
DNMT3A 1788 Q9Y6K1
Anti-Ratte DNMT3A DNMT3A 444984 Q1LZ53
Anti-Maus DNMT3A DNMT3A 13435 O88508
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.061 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
$736.84
Details

Weitere ELISA Kits für DNMT3A Interaktionspartner

Pig (Porcine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a, Hdac1, Kdm3a and Uhrf1 were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

Human DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. In univariable analysis, patients carrying mutations in DNMT3A, U2AF1, and EZH2 (zeige EZH2 ELISA Kits) had worse overall and relapse-free survival.

  2. Elastic Network Models, information theory, Protein Structure Network, and sequence evolution analysis were used to investigate intrinsic dynamics and allosteric properties of DNMT3A resolved in autoinhibitory and active states. The conformational transition between 2 states shows global motions. The dimer interface has a major role in defining the quaternary structure dynamics and establishing interdomain communication.

  3. HIF1A (zeige HIF1A ELISA Kits)-AS2 (zeige ARSA ELISA Kits) exerted the oncogenic functions in CRC (zeige CALR ELISA Kits) through regulating miR (zeige MLXIP ELISA Kits)-129-5p/DNMT3A axis.

  4. we found that DNMT3A was responsible for the down-regulation of miR (zeige MLXIP ELISA Kits)-105 in gastric cancer cells

  5. Taken together, these data demonstrate that adipose Dnmt3a is a novel epigenetic mediator of insulin (zeige INS ELISA Kits) resistance in vitro and in vivo.

  6. Low frequency of DNMT3A mutations in pediatric T-ALL is in striking contrast to adult T-ALL and renders the necessity for the search of other candidate prognostic markers. Combined Sanger sequencing-HRM approach offers a cost-effective option for genotyping DNMT3A coding sequence, with potential clinical application in other hematological malignancies.

  7. 2.65-angstrom crystal structure of the DNMT3A-DNMT3L-DNA complex in which two DNMT3A monomers simultaneously attack two cytosine-phosphate-guanine (CpG) dinucleotides, with the target sites separated by 14 base pairs within the same DNA duplex; mechanistic basis for DNMT3A-mediated DNA methylation and establishment of its aetiological link to human disease

  8. based on the investigation of previously reported variants in patients with Tatton-Brown-Rahman syndrome , we found overlap in the spectrum of DNMT3A variants observed in this disorder and somatic variants in hematological malignancies

  9. The emodininduced downregulation of UHRF1 led to an increase in the level of DNA methyltransferase 3A.

  10. Data suggest that miR (zeige MLXIP ELISA Kits)-200b-3p may exhibit targeting and suppressive effects on DNA methyltransferase 3A (DNMT3A).

Horse (Equine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation content are rather a function of time, and not a genetic component.

Cow (Bovine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. The effect of p53 (zeige TP53 ELISA Kits) expression on the development of cloned embryos, and its interaction with HDAC1 (zeige HDAC1 ELISA Kits) and DNMT3A are reported.

  2. The expression levels of DNMT3a and DNMT3b (zeige DNMT3B ELISA Kits) were associated with several beef quality traits.

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. individual pain vulnerability may be inherent mostly in the emotional/affective component of chronic pain and remain consistent in different aspects of negative emotion, in which adaptive changes in the function of DNA methyltransferase 3a for DNA methylation in central amygdala may play an important role.

  2. Taken together, these data demonstrate that adipose Dnmt3a is a novel epigenetic mediator of insulin (zeige INS ELISA Kits) resistance in vitro and in vivo.

  3. The aim of the present study is to investigate spatial and temporal expression levels and subcellular localizations of the DNMT1 (zeige DNMT1 ELISA Kits), DNMT3A, and DNMT3B (zeige DNMT3B ELISA Kits) proteins in the mouse germinal vesicle (GV) and metaphase II (MII) oocytes, and early embryos from 1-cell to blastocyst stages.

  4. our Dnmt3a R878H mice have shown that leukemic cells have altered gene expression and epigenetic regulatory patterns contributing to the growth/survival advantage over WT mice.The present study found that the DNMT3A mutation contributed to hypomethylation in the gene body region of mTOR (zeige FRAP1 ELISA Kits) in Dnmt3aR878H/WT mice.

  5. Knockdown of DNMT3A or DNMT1 protected neurons against mutant Htt-induced toxicity, together demonstrating a requirement for DNMTs in mutant Htt-triggered neuronal death and suggesting a neurodegenerative mechanism based on DNA methylation-mediated transcriptional repression.

  6. Data demonstrate that DNMT3A and DNA methylation are key modulators of mast cell responsiveness to acute and chronic stimulation.

  7. These data suggest that DNMT3a is required for nerve injury-induced and MBD1 (zeige DPEP1 ELISA Kits)-mediated epigenetic silencing of the MOR (zeige OPRM1 ELISA Kits) and KOR (zeige OPRK1 ELISA Kits) in the injured DRG. DNMT3a inhibition may serve as a promising adjuvant therapy for opioid use in neuropathic pain management.

  8. Data show that conditional deletion of Dnmt3a and simultaneous "knock in" of Flt3ITD/+, cooperate to drive leukemia development at a faster rate than Dnmt3a loss alone.

  9. Deletion of DNMT3a in postnatal forebrain neurons does no alter affective behavior.

  10. Altogether, the authors demonstrate that Dnmt3a and Dnmt3b (zeige DNMT3B ELISA Kits) protect the epidermis from tumorigenesis and that squamous carcinomas are sensitive to inhibition of PPAR-gamma (zeige PPARG ELISA Kits).

DNMT3A Antigen-Profil

Beschreibung des Gens

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit DNMT3A

  • DNA methyltransferase 3 alpha (DNMT3A) Antikörper
  • DNA methyltransferase 3 alpha (dnmt3a) Antikörper
  • DNA methyltransferase 3 alpha (Dnmt3a) Antikörper
  • DNA methyltransferase 3A (Dnmt3a) Antikörper
  • DNMT3A Antikörper
  • DNMT3A2 Antikörper
  • M.HsaIIIA Antikörper
  • MmuIIIA Antikörper

Bezeichner auf Proteinebene für DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha , DNA cytosine methyltransferase 3 alpha , DNA (cytosine-5)-methyltransferase 3A , DNA methyl transferase alpha , DNA methyltransferase 3A , DNA MTase HsaIIIA , DNA cytosine methyltransferase 3A2 , DNA-methyltransferase 3a , DNA MTase MmuIIIA , DNA methyltransferase MmuIIIA

GENE ID SPEZIES
482996 Canis lupus familiaris
694822 Macaca mulatta
739139 Pan troglodytes
100037301 Sus scrofa
100030681 Monodelphis domestica
100344715 Oryctolagus cuniculus
100500776 Ovis aries
100594618 Nomascus leucogenys
100529107 Anolis carolinensis
1788 Homo sapiens
421991 Gallus gallus
100510798 Felis catus
100055881 Equus caballus
359716 Bos taurus
444984 Rattus norvegicus
13435 Mus musculus
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