anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Antikörper

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Zusätzlich bieten wir Ihnen DNA (Cytosine-5)-Methyltransferase 1 Kits (28) und DNA (Cytosine-5)-Methyltransferase 1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
DNMT1 1786 P26358
DNMT1 84350  
DNMT1 13433 P13864
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Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert ChIP, CyTOF, FACS, ICC, IF, IHC, IHC (ff), IHC (fro), IHC (p), IP, SimWes, WB Western Blot: Dnmt1 Antibody (60B1220.1) [ABIN252481] - Western blot analysis for Dnmt1 using ABIN252481 at 2 ug/ml against 10 µg of cell lysates of mouse ES cell. Immunohistochemistry: Dnmt1 Antibody (60B1220.1) [ABIN252481] - IHC analysis of Dnmt1 using ABIN252481 at 2 ug/ml on formalin-fixed, paraffin-embedded medullar kidney tissue sections 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
Human Maus Unkonjugiert ChIP, IP, IHC, WB DNMT1 antibody (mAb) tested by Western blot. Detection of DNMT1 by Western blot. The analysis was performed using mouse ES whole-cell extract and DNMT1 antibody (mAb) at a 2 µg/ml dilution. 100 μg Anmelden zum Anzeigen 1 bis 2 Tage
Maus Kaninchen Unkonjugiert WB Researcher: AnonymousApplication: Western BlottingSpecies+tissue/cell type: Lane 1:241 µg mouse mesenchymal stem cell lysate Primary Antibody dilution: 1:0000<br />Secondary Antibody: Anti-rabbit-HRP <br />Secondary Antibody Dilution: 1:00,000 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
Human Kaninchen Unkonjugiert WB Western blot analysis of DNMT1 Antibody (S1105) (ABIN387879) in MDA-MB435 cell line lysates (35 µg/lane). DNMT1 (arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
Human Kaninchen Unkonjugiert FACS, WB The anti-Dnmt1 C-term Pab (ABIN387878) is used in Western blot to detect Dnmt1 in Jurkat cell lysate. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
Human Kaninchen Unkonjugiert DB Dot blot analysis of anti-Dnmt1 Phospho-specific Pab (ABIN389901) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
Fisch Maus Unkonjugiert ChIP, IP, IHC, WB Dnmt1, 18ug H1299 lysate 1 in1000 Western Blotting. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
Fisch Maus Unkonjugiert ChIP, IP, IHC, WB Dnmt1, 18ug H1299 lysate 1 in1000 Western Blotting. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
Human Kaninchen Unkonjugiert EIA, WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
Human Kaninchen Unkonjugiert IF (p), IHC (p) Formalin-fixed and paraffin embedded mouse lymphoma tissue labeled with Anti-Dnmt1 Polyclonal Antibody, Unconjugated (ABIN671796) at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-Dnmt1 Polyclonal Antibody, Unconjugated (ABIN671796) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 3 bis 7 Tage

DNMT1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-DNA (Cytosine-5)-Methyltransferase 1 Antikörper

  1. Human Monoclonal DNMT1 Primary Antibody für ChIP, CyTOF - ABIN252481 : Dennis, Fan, Geiman, Yan, Muegge: Lsh, a member of the SNF2 family, is required for genome-wide methylation. in Genes & development 2001 (PubMed)
    Show all 106 Pubmed References

  2. Human Monoclonal DNMT1 Primary Antibody für IF, WB - ABIN968896 : Robertson, Ait-Si-Ali, Yokochi, Wade, Jones, Wolffe: DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. in Nature genetics 2000 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal DNMT1 Primary Antibody für ChIP, IP - ABIN2668504 : Schnekenburger, Talaska, Puga: Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. in Molecular and cellular biology 2007 (PubMed)
    Show all 4 Pubmed References

  4. Human Monoclonal DNMT1 Primary Antibody für IF, WB - ABIN968895 : Robertson, Uzvolgyi, Liang, Talmadge, Sumegi, Gonzales, Jones: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. in Nucleic acids research 1999 (PubMed)
    Show all 4 Pubmed References

  5. Human Polyclonal DNMT1 Primary Antibody für DB, ELISA - ABIN4369817 : Saito, Kanai, Nakagawa, Sakamoto, Saito, Ishii, Hirohashi: Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. in International journal of cancer. Journal international du cancer 2003 (PubMed)
    Show all 3 Pubmed References

  6. Human Polyclonal DNMT1 Primary Antibody für IHC (p), IHC - ABIN314281 : Nanduri, Makarenko, Reddy, Yuan, Pawar, Wang, Khan, Zhang, Kinsman, Peng, Kumar, Fox, Godley, Semenza, Prabhakar: Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal DNMT1 Primary Antibody für FACS, WB - ABIN387878 : Peterson, Bögler, Taylor: p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. in Cancer research 2003 (PubMed)
    Show all 7 Pubmed References

  8. Human Polyclonal DNMT1 Primary Antibody für WB - ABIN387879 : Leu, Rahmatpanah, Shi, Wei, Liu, Yan, Huang: Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation. in Cancer research 2003 (PubMed)
    Show all 7 Pubmed References

  9. Human Polyclonal DNMT1 Primary Antibody für IF (p), IHC (p) - ABIN671796 : Khan, Tania, Wei, Mei, Fu, Cheng, Xu, Fu: Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition. in Oncotarget 2015 (PubMed)

  10. Human Polyclonal DNMT1 Primary Antibody für WB - ABIN151855 : Min, Kim, Choi, Liang, Ko, Rhee, Bang, Ham, Park, Lee: Selective death of cancer cells by preferential induction of reactive oxygen species in response to (-)-epigallocatechin-3-gallate. in Biochemical and biophysical research communications 2012 (PubMed)

Weitere Antikörper gegen DNA (Cytosine-5)-Methyltransferase 1 Interaktionspartner

Zebrafish DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Interaktionspartner

  1. Dnmt1 stability requires UHRF1 (zeige UHRF1 Antikörper) phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation

  2. Lsh (zeige HELLS Antikörper) Is Essential for Maintaining Global DNA Methylation (zeige HELLS Antikörper) Levels in Amphibia and Fish and Interacts Directly with Dnmt1.

  3. Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa (zeige CEBPA Antikörper) regulation during definitive hematopoiesis in zebrafish

  4. These data provide the first evidence that Uhrf1 (zeige UHRF1 Antikörper) and Dnmt1 function is required for vertebrate lens development and maintenance.

  5. These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 (zeige SUV39H1 Antikörper) and that, together, Dnmt1 and Suv39h1 (zeige SUV39H1 Antikörper) help guide the terminal differentiation of particular tissues.

  6. Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.

  7. Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.

Human DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Interaktionspartner

  1. PRIMA-1 could cause the demethylation of TP73 (zeige TP73 Antikörper), through DNMT1 depletion, to subsequently enhance the unfolded protein response

  2. Results show that DNMT1 is highly expressed in lung tumors compared to normal tissues, and that DBCCR1 attenuates its expression suggesting a reciprocal regulation between genetic silencing of cancer suppressor genes and activating DNA methylation (zeige HELLS Antikörper).

  3. A decreased expression of anti-DNMT1 miRNAs might account for azacitidine resistance in higher-risk myelodysplastic syndrome and acute myeloid leukemia (zeige BCL11A Antikörper) , and measuring miRNA expression before and during treatment might help predict primary or secondary azacitidine resistance

  4. these findings revealed that miR (zeige MLXIP Antikörper)-217 promotes fibroblasts senescence by suppressing DNMT1-mediated methylation of p16 and pRb (zeige RB1 Antikörper) by targeting the DNMT1 3'-UTR (zeige UTS2R Antikörper).

  5. Ultraviolet B rays suppressed SIRT1 (zeige SIRT1 Antikörper) expression by activating AhR (zeige AHR Antikörper), and subsequently inhibited DNMT1 activity in CD4 (zeige CD4 Antikörper)+ T cells from systemic lupus erythematosus patients.

  6. DNMT1 expression is increased in low-grade gliomas and is associated with improved survival. Its expression is regulated by phosphorylated c-Jun (zeige JUN Antikörper) and correlates with high DNA methylation (zeige HELLS Antikörper).

  7. in patents with chronic hepatitis B, data showed a DNMT1 overexpression significantly correlated to nucleo(t)side analogs (NA) therapy duration and higher regional mitochondrial DNA hypermethylation; this might suggest an epigenetic alteration that could be involved in one of the possible mechanisms of mitochondrial gene regulation during NAs (zeige SCN9A Antikörper) therapy

  8. The meta-analysis also suggested that DNMT1 rs16999593 (T/C) may be associated with gastric cancer, while rs2228611 (G/A) may be associated with breast cancer. In future research, large-scale and well-designed studies are required to verify these findings.

  9. FQI1 mediates alteration of the tumor epigenome by DNMT1-LSF (zeige TFCP2 Antikörper) complex disruption, leading to aberrant DNA methylation (zeige HELLS Antikörper) and gene expression.

  10. DNMT1-mediated transcriptional upregulation of IGF2 is a novel mechanism of resistance to HDIs, highlighting the role of epigenetic deregulation of IGF2 in HDI resistance and the potential value of the H19 (zeige NCKAP1 Antikörper)/IGF2 ICR hypermethylation and DNMT1 expression as predictive biomarkers in HDI-based anticancer therapies.

Pig (Porcine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Interaktionspartner

  1. Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.

  2. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a (zeige DNMT3A Antikörper), Hdac1 (zeige HDAC1 Antikörper), Kdm3a (zeige KDM3A Antikörper) and Uhrf1 (zeige UHRF1 Antikörper) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

  3. DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm (zeige NLRP5 Antikörper) cortex of oocytes and cytoplasm of early embryos.

  4. results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos

  5. Oocyte-specific Dnmt1 is cytoplasmic during early development.

  6. Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.

Cow (Bovine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Interaktionspartner

  1. DNMT1 silencing significantly decreased the methylation levels of miR (zeige MYLIP Antikörper)-29b promoter, up-regulated miR (zeige MYLIP Antikörper)-29b expression and inhibited bovine viral diarrhea virus replication.

  2. Through down-regulating the expression of DNMT1, miR (zeige MYLIP Antikörper)-152 reduced Global DNA methylation (zeige HELLS Antikörper) and the activity of DNMT to reactivate the lactation signal transduction genes Akt (zeige AKT1 Antikörper) and Ppar gamma (zeige PPARG Antikörper).

  3. More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (zeige ASCL2 Antikörper) mRNA was present at highest levels in transgenic SCNT embryos.

  4. Our results indicate an essential role for Dnmt1 during bovine preimplantation development (zeige MTA2 Antikörper), and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.

  5. Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes, it enters the nuclei of 8-16 cell stage embryos

  6. Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.

  7. Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.

  8. Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.

Arabidopsis thaliana DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Interaktionspartner

  1. Long-term stability and epigenetic features differ for individual loci. Our data show that over-expression of MET1, and potentially of other genes encoding epigenetic factors, offers an alternative strategy to identify epigenetic target genes and to create novel epi (zeige TFPI Antikörper)-alleles

  2. MET1 confines ARID1 to the vegetative cell of male gametes, but ARID1 conversely represses MET1 in the central cell of female gametes.

  3. MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis

  4. Met1 gene expression throughout normal development, particularly in the flower

  5. MET1 is a contributor to epigenetic diversity in Arabidopsis.

  6. VIM (zeige VIM Antikörper) proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation (zeige HELLS Antikörper) and histone modification status in collaboration with MET1

  7. VIM (zeige VIM Antikörper) proteins function in transcriptional regulation via their roles in the MET1 DNA methylation (zeige HELLS Antikörper) pathway.

  8. Genetic studies indicate that the Polycomb (zeige CBX2 Antikörper) Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]

  9. MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.

  10. There is a mechanistic link between two major epigenetic pathways involved in histone and DNA methylation (zeige HELLS Antikörper) in plants by physical interaction of MET1 with the FIS-PRC2 core component MEA.

Mouse (Murine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Interaktionspartner

  1. Sp1 (zeige SP1 Antikörper)/NFkappaB p65 (zeige NFkBP65 Antikörper)-Dnmt1 pathway may be exploited as a therapeutic target for protecting against podocyte injury in diabetic nephropathy.

  2. 2-hydroxyglutarate bound to DNMT1 and stimulated its association with the RIP3 (zeige MPRIP Antikörper) promoter, inducing hypermethylation that reduces RIP3 (zeige MPRIP Antikörper) protein and consequently impaired RIP3 (zeige MPRIP Antikörper)-dependent necroptosis.

  3. The results demonstrated that Islet1 (zeige ISL1 Antikörper) upregulated expression of general control of amino acid biosynthesis protein 5 (zeige CAPS Antikörper) (Gcn5 (zeige KAT2A Antikörper)) and enhanced the binding of Gcn5 (zeige KAT2A Antikörper) to the promoters of GATA binding protein 4 (GATA4 (zeige GATA4 Antikörper)) and NK2 homeobox 5 (Nkx2.5 (zeige NKX2-5 Antikörper)). In addition, Islet-1 (zeige ISL1 Antikörper) downregulated DNA methyltransferase (DNMT)1 expression and reduced its binding to the GATA4 (zeige GATA4 Antikörper) promoter.

  4. Data show that RGS6 (zeige RGS6 Antikörper) loss impairs p53 (zeige TP53 Antikörper) activation and promotes aberrant accumulation of oncogenic protein DNMT1 in urothelium.

  5. Data (including data from studies using knockout/transgenic mice) suggest that neuronal Dnmt1 regulates energy homeostasis through pathways controlling energy homeostasis; here, neuronal Dnmt1 deficiency prevents diet-induced obesity, reduces adiposity, reduces food intake, and increases energy expenditure in male mice.

  6. Deletion of DNmt1 in postnatal forebrain neurons results in anxiolytic and antidepressant-like responses.

  7. Upon lysolecithin injection in the spinal cord of transgenic mice, study detected defective oligodendrocyte progenitor cells differentiation and inefficient remyelination in the DNA methyltransferase 3a (zeige DNMT3A Antikörper) null and DNA methyltransferase 1/DNA methyltransferase 3a (zeige DNMT3A Antikörper) null mice.

  8. Data from studies using mouse embryonic fibroblasts suggest that cell proliferation rate positively correlates with expression of Dnmt1 in G1 phase; global DNA methylation (zeige HELLS Antikörper) is significantly higher in G1 phase than in G2/M phase; larger methylation differences are observed on promoters of pluripotency-related genes; thus, high cell proliferation rates promote generation of induced pluripotent stem cells.

  9. Dnmt1 and Ezh2 (zeige EZH2 Antikörper) play distinct roles in the different islet cell types

  10. we extended this work by using a biotinylation tagging approach to characterize DNMT1 protein complexes in mouse erythroleukemic cells. We identified novel DNMT1 interactions with several hematopoietic transcription factors with essential roles in erythroid differentiation

DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Antigen-Profil

Protein Überblick

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit DNMT1

  • DNA methyltransferase 1 (DNMT1) Antikörper
  • DNA (cytosine-5-)-methyltransferase 1 (dnmt1) Antikörper
  • DNA methyltransferase 1 (Dnmt1) Antikörper
  • methyltransferase 1 (MET1) Antikörper
  • DNA methyltransferase (cytosine-5) 1 (Dnmt1) Antikörper
  • ADCADN Antikörper
  • AIM Antikörper
  • cb983 Antikörper
  • cb1075 Antikörper
  • Cxxc9 Antikörper
  • DDM2 Antikörper
  • dmnt1 Antikörper
  • DMT01 Antikörper
  • DMT1 Antikörper
  • Dnmt Antikörper
  • Dnmt1o Antikörper
  • fb05h01 Antikörper
  • HSN1E Antikörper
  • m.MmuI Antikörper
  • MCMT Antikörper
  • Met-1 Antikörper
  • Met1 Antikörper
  • MET2 Antikörper
  • methyltransferase 1 Antikörper
  • METI Antikörper
  • MommeD2 Antikörper
  • mta Antikörper
  • MTase Antikörper
  • wu:fb05h01 Antikörper

Bezeichner auf Proteinebene für DNMT1

DNA (cytosine-5)-methyltransferase 1 , ddn , CXXC-type zinc finger protein 9 , DNA MTase HsaI , DNA methyltransferase HsaI , m.HsaI , DNA methyltransferase 1 , DNA (cytosine 5 ) methyltransferase 1 , DNA methyltransferase (cytosine 5 ) methyltransferase , DNA methyltransferase b , DNA MTase RnoIP , DNA methyltransferase (cytosine-5) 1 , DNA methyltransferase I , MCMT , m.RnoIP , DNA MTase GgaI , DNA MeTase , DNA methyltransferase GgaI , m.GgaI , DNA MTase MmuI , DNA methyltransferase MmuI

443549 Ovis aries
30430 Danio rerio
1786 Homo sapiens
476715 Canis lupus familiaris
606746 Sus scrofa
281119 Bos taurus
84350 Rattus norvegicus
396011 Gallus gallus
834975 Arabidopsis thaliana
13433 Mus musculus
Ausgewählte Anbieter für anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Antikörper
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