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DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Zusätzlich bieten wir Ihnen DNA (Cytosine-5)-Methyltransferase 1 Kits (28) und DNA (Cytosine-5)-Methyltransferase 1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal DNMT1 Primary Antibody für ChIP, CyTOF - ABIN252481
Dennis, Fan, Geiman, Yan, Muegge: Lsh, a member of the SNF2 family, is required for genome-wide methylation. in Genes & development 2001
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Human Monoclonal DNMT1 Primary Antibody für IF, WB - ABIN968896
Robertson, Ait-Si-Ali, Yokochi, Wade, Jones, Wolffe: DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. in Nature genetics 2000
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Human Monoclonal DNMT1 Primary Antibody für ChIP, IP - ABIN2668504
Schnekenburger, Talaska, Puga: Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. in Molecular and cellular biology 2007
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Human Monoclonal DNMT1 Primary Antibody für IF, WB - ABIN968895
Robertson, Uzvolgyi, Liang, Talmadge, Sumegi, Gonzales, Jones: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. in Nucleic acids research 1999
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Human Polyclonal DNMT1 Primary Antibody für DB, ELISA - ABIN4369817
Saito, Kanai, Nakagawa, Sakamoto, Saito, Ishii, Hirohashi: Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. in International journal of cancer. Journal international du cancer 2003
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Human Polyclonal DNMT1 Primary Antibody für IHC (p), IHC - ABIN314281
Nanduri, Makarenko, Reddy, Yuan, Pawar, Wang, Khan, Zhang, Kinsman, Peng, Kumar, Fox, Godley, Semenza, Prabhakar: Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. in Proceedings of the National Academy of Sciences of the United States of America 2012
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Human Polyclonal DNMT1 Primary Antibody für FACS, WB - ABIN387878
Peterson, Bögler, Taylor: p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. in Cancer research 2003
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Human Polyclonal DNMT1 Primary Antibody für WB - ABIN387879
Leu, Rahmatpanah, Shi, Wei, Liu, Yan, Huang: Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation. in Cancer research 2003
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Human Polyclonal DNMT1 Primary Antibody für IF (p), IHC (p) - ABIN671796
Khan, Tania, Wei, Mei, Fu, Cheng, Xu, Fu: Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition. in Oncotarget 2015
Human Polyclonal DNMT1 Primary Antibody für WB - ABIN151855
Min, Kim, Choi, Liang, Ko, Rhee, Bang, Ham, Park, Lee: Selective death of cancer cells by preferential induction of reactive oxygen species in response to (-)-epigallocatechin-3-gallate. in Biochemical and biophysical research communications 2012
Dnmt1 stability requires UHRF1 (zeige UHRF1 Antikörper) phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation
Lsh (zeige HELLS Antikörper) Is Essential for Maintaining Global DNA Methylation (zeige HELLS Antikörper) Levels in Amphibia and Fish and Interacts Directly with Dnmt1.
Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa (zeige CEBPA Antikörper) regulation during definitive hematopoiesis in zebrafish
These data provide the first evidence that Uhrf1 (zeige UHRF1 Antikörper) and Dnmt1 function is required for vertebrate lens development and maintenance.
These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 (zeige SUV39H1 Antikörper) and that, together, Dnmt1 and Suv39h1 (zeige SUV39H1 Antikörper) help guide the terminal differentiation of particular tissues.
Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.
Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.
PRIMA-1 could cause the demethylation of TP73 (zeige TP73 Antikörper), through DNMT1 depletion, to subsequently enhance the unfolded protein response
Results show that DNMT1 is highly expressed in lung tumors compared to normal tissues, and that DBCCR1 attenuates its expression suggesting a reciprocal regulation between genetic silencing of cancer suppressor genes and activating DNA methylation (zeige HELLS Antikörper).
A decreased expression of anti-DNMT1 miRNAs might account for azacitidine resistance in higher-risk myelodysplastic syndrome and acute myeloid leukemia (zeige BCL11A Antikörper) , and measuring miRNA expression before and during treatment might help predict primary or secondary azacitidine resistance
these findings revealed that miR (zeige MLXIP Antikörper)-217 promotes fibroblasts senescence by suppressing DNMT1-mediated methylation of p16 and pRb (zeige RB1 Antikörper) by targeting the DNMT1 3'-UTR (zeige UTS2R Antikörper).
Ultraviolet B rays suppressed SIRT1 (zeige SIRT1 Antikörper) expression by activating AhR (zeige AHR Antikörper), and subsequently inhibited DNMT1 activity in CD4 (zeige CD4 Antikörper)+ T cells from systemic lupus erythematosus patients.
DNMT1 expression is increased in low-grade gliomas and is associated with improved survival. Its expression is regulated by phosphorylated c-Jun (zeige JUN Antikörper) and correlates with high DNA methylation (zeige HELLS Antikörper).
in patents with chronic hepatitis B, data showed a DNMT1 overexpression significantly correlated to nucleo(t)side analogs (NA) therapy duration and higher regional mitochondrial DNA hypermethylation; this might suggest an epigenetic alteration that could be involved in one of the possible mechanisms of mitochondrial gene regulation during NAs (zeige SCN9A Antikörper) therapy
The meta-analysis also suggested that DNMT1 rs16999593 (T/C) may be associated with gastric cancer, while rs2228611 (G/A) may be associated with breast cancer. In future research, large-scale and well-designed studies are required to verify these findings.
FQI1 mediates alteration of the tumor epigenome by DNMT1-LSF (zeige TFCP2 Antikörper) complex disruption, leading to aberrant DNA methylation (zeige HELLS Antikörper) and gene expression.
DNMT1-mediated transcriptional upregulation of IGF2 is a novel mechanism of resistance to HDIs, highlighting the role of epigenetic deregulation of IGF2 in HDI resistance and the potential value of the H19 (zeige NCKAP1 Antikörper)/IGF2 ICR hypermethylation and DNMT1 expression as predictive biomarkers in HDI-based anticancer therapies.
Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a (zeige DNMT3A Antikörper), Hdac1 (zeige HDAC1 Antikörper), Kdm3a (zeige KDM3A Antikörper) and Uhrf1 (zeige UHRF1 Antikörper) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm (zeige NLRP5 Antikörper) cortex of oocytes and cytoplasm of early embryos.
results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos
Oocyte-specific Dnmt1 is cytoplasmic during early development.
Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.
DNMT1 silencing significantly decreased the methylation levels of miR (zeige MYLIP Antikörper)-29b promoter, up-regulated miR (zeige MYLIP Antikörper)-29b expression and inhibited bovine viral diarrhea virus replication.
Through down-regulating the expression of DNMT1, miR (zeige MYLIP Antikörper)-152 reduced Global DNA methylation (zeige HELLS Antikörper) and the activity of DNMT to reactivate the lactation signal transduction genes Akt (zeige AKT1 Antikörper) and Ppar gamma (zeige PPARG Antikörper).
More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (zeige ASCL2 Antikörper) mRNA was present at highest levels in transgenic SCNT embryos.
Our results indicate an essential role for Dnmt1 during bovine preimplantation development (zeige MTA2 Antikörper), and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.
Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes, it enters the nuclei of 8-16 cell stage embryos
Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.
Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.
Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.
Long-term stability and epigenetic features differ for individual loci. Our data show that over-expression of MET1, and potentially of other genes encoding epigenetic factors, offers an alternative strategy to identify epigenetic target genes and to create novel epi (zeige TFPI Antikörper)-alleles
MET1 confines ARID1 to the vegetative cell of male gametes, but ARID1 conversely represses MET1 in the central cell of female gametes.
MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis
Met1 gene expression throughout normal development, particularly in the flower
MET1 is a contributor to epigenetic diversity in Arabidopsis.
VIM (zeige VIM Antikörper) proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation (zeige HELLS Antikörper) and histone modification status in collaboration with MET1
VIM (zeige VIM Antikörper) proteins function in transcriptional regulation via their roles in the MET1 DNA methylation (zeige HELLS Antikörper) pathway.
Genetic studies indicate that the Polycomb (zeige CBX2 Antikörper) Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]
MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.
There is a mechanistic link between two major epigenetic pathways involved in histone and DNA methylation (zeige HELLS Antikörper) in plants by physical interaction of MET1 with the FIS-PRC2 core component MEA.
Sp1 (zeige SP1 Antikörper)/NFkappaB p65 (zeige NFkBP65 Antikörper)-Dnmt1 pathway may be exploited as a therapeutic target for protecting against podocyte injury in diabetic nephropathy.
2-hydroxyglutarate bound to DNMT1 and stimulated its association with the RIP3 (zeige MPRIP Antikörper) promoter, inducing hypermethylation that reduces RIP3 (zeige MPRIP Antikörper) protein and consequently impaired RIP3 (zeige MPRIP Antikörper)-dependent necroptosis.
The results demonstrated that Islet1 (zeige ISL1 Antikörper) upregulated expression of general control of amino acid biosynthesis protein 5 (zeige CAPS Antikörper) (Gcn5 (zeige KAT2A Antikörper)) and enhanced the binding of Gcn5 (zeige KAT2A Antikörper) to the promoters of GATA binding protein 4 (GATA4 (zeige GATA4 Antikörper)) and NK2 homeobox 5 (Nkx2.5 (zeige NKX2-5 Antikörper)). In addition, Islet-1 (zeige ISL1 Antikörper) downregulated DNA methyltransferase (DNMT)1 expression and reduced its binding to the GATA4 (zeige GATA4 Antikörper) promoter.
Data show that RGS6 (zeige RGS6 Antikörper) loss impairs p53 (zeige TP53 Antikörper) activation and promotes aberrant accumulation of oncogenic protein DNMT1 in urothelium.
Data (including data from studies using knockout/transgenic mice) suggest that neuronal Dnmt1 regulates energy homeostasis through pathways controlling energy homeostasis; here, neuronal Dnmt1 deficiency prevents diet-induced obesity, reduces adiposity, reduces food intake, and increases energy expenditure in male mice.
Deletion of DNmt1 in postnatal forebrain neurons results in anxiolytic and antidepressant-like responses.
Upon lysolecithin injection in the spinal cord of transgenic mice, study detected defective oligodendrocyte progenitor cells differentiation and inefficient remyelination in the DNA methyltransferase 3a (zeige DNMT3A Antikörper) null and DNA methyltransferase 1/DNA methyltransferase 3a (zeige DNMT3A Antikörper) null mice.
Data from studies using mouse embryonic fibroblasts suggest that cell proliferation rate positively correlates with expression of Dnmt1 in G1 phase; global DNA methylation (zeige HELLS Antikörper) is significantly higher in G1 phase than in G2/M phase; larger methylation differences are observed on promoters of pluripotency-related genes; thus, high cell proliferation rates promote generation of induced pluripotent stem cells.
Dnmt1 and Ezh2 (zeige EZH2 Antikörper) play distinct roles in the different islet cell types
we extended this work by using a biotinylation tagging approach to characterize DNMT1 protein complexes in mouse erythroleukemic cells. We identified novel DNMT1 interactions with several hematopoietic transcription factors with essential roles in erythroid differentiation
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
DNA (cytosine-5)-methyltransferase 1
, CXXC-type zinc finger protein 9
, DNA MTase HsaI
, DNA methyltransferase HsaI
, DNA methyltransferase 1
, DNA (cytosine 5 ) methyltransferase 1
, DNA methyltransferase (cytosine 5 ) methyltransferase
, DNA methyltransferase b
, DNA MTase RnoIP
, DNA methyltransferase (cytosine-5) 1
, DNA methyltransferase I
, DNA MTase GgaI
, DNA MeTase
, DNA methyltransferase GgaI
, DNA MTase MmuI
, DNA methyltransferase MmuI