anti-DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) Antikörper

Pig (Porcine) DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) Interaktionspartner

1. polymorphism-based approach was used to detect the imprinting status of NNAT (zeige NNAT Antikörper) and DIRAS3 genes in five heterozygous pigs (based on SNP) of Large White and Meishan F(1) hybrids

Human DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) Interaktionspartner

1. lncRNA GAS5 functions as a competing endogenous RNA for miR (zeige MLXIP Antikörper)-221 to suppress cell growth and EMT (zeige ITK Antikörper) in osteosarcoma by regulating the miR (zeige MLXIP Antikörper)-221/ARHI pathway.

2. DiRas3 binds to KSR1 (zeige KSR1 Antikörper) independently of its interaction with activated Ras and RAF (zeige RAF1 Antikörper).

3. We demonstrate that DIRAS3 knock-down (KD) in adipose stromal/progenitor cells (ASCs) induces activation of Akt (zeige AKT1 Antikörper)-mTOR (zeige FRAP1 Antikörper) signaling and proliferation arrest. DIRAS3 KD ASCs lose the potential to form colonies and are negative for Ki-67 (zeige MKI67 Antikörper). Moreover, silencing of DIRAS3 results in a premature senescence phenotype.

4. ARHI-mediated up-regulation of glycolysis and glutaminolysis was found to be autophagy-dependent and inhibition of these metabolic pathways resulted in decreased cell viability.

5. The overexpression of ARHI promotes colon cancer SW480 cell apoptosis by inhibiting the level of Akt (zeige AKT1 Antikörper).

6. Transcriptional, but not post-transcriptional, silencing of GNG12-AS1 (zeige PTGDR Antikörper) causes concomitant upregulation of DIRAS3, indicating a function in transcriptional interference.

7. ARHI mRNA and protein expression is markedly decreased in osteosarcoma MG-63 cells lines. Overexpression of ARHI inhibits cell viability and proliferation.

8. ARHI-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts.

9. EZH2 (zeige EZH2 Antikörper)-''induced H3K27me3 is associated with epigenetic repression of the ARHI tumor-suppressor gene in epithelial ovarian cancer

10. ARHI competes with RanGTPase and interacts with importin beta (zeige KPNB1 Antikörper) via basic-acidic patch interaction, which leads to inhibition of STAT3 (zeige STAT3 Antikörper) translocation.