DEP Domain Containing 2 (DEPDC2) ELISA Kits

Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Zusätzlich bieten wir Ihnen DEP Domain Containing 2 Antikörper (14) und DEP Domain Containing 2 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
DEPDC2 80243 Q70Z35
DEPDC2 109294 Q3LAC4
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Top DEP Domain Containing 2 ELISA Kits auf antikoerper-online.de

Showing 2 out of 7 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 34 pg/mL 78-5000 pg/mL   96 Tests Anmelden zum Anzeigen 2 bis 3 Tage
$779.90
Details
Maus 78 pg/mL - 5000 pg/mL   96 Tests Anmelden zum Anzeigen 11 bis 18 Tage
$589.86
Details

Weitere ELISA Kits für DEP Domain Containing 2 Interaktionspartner

Human DEP Domain Containing 2 (DEPDC2) Interaktionspartner

  1. MiR (zeige MLXIP ELISA Kits)-338-3p suppresses the TNF-alpha (zeige TNF ELISA Kits)-induced lipogenesis in sebocytes by targeting PREX2a and down-regulating PI3K (zeige PIK3CA ELISA Kits)/AKT (zeige AKT1 ELISA Kits) signaling.

  2. Data suggest that PREX1 (zeige PREX1 ELISA Kits) and PREX2 share similarities in amino acid sequence, domain structure, activation by PIP(3) [phosphatidylinositol 3,4,5-triphosphate] and G-protein-coupled receptors beta/gamma subunits; expression of PREX1 (zeige PREX1 ELISA Kits) and PREX2 is altered in many cancers. [REVIEW]

  3. complex signaling mechanisms that involve PREX2, PI3K/AKT/PTEN and downstream epigenetic machinery to deregulate expression of key cell cycle regulators

  4. PREX2 was identified as a frequently mutated gene in human melanoma. .. mutation of PREX2 can accelerate human melanoma growth.

  5. The rapid tumor onset observed in this replication attempt, compared to the original study, makes the detection of accelerated tumor growth in PREX2 expressing NRAS (zeige NRAS ELISA Kits)(G12D) melanocytes extremely difficult.

  6. Elevated PREX2 protein expression is associated with pathogenesis of hepatocellular carcinoma.

  7. The results of the present study suggested that PREX2a may act as an oncogene in osteosarcoma via the inhibition of PTEN activity and activation of PI3K signaling.

  8. findings identify PREX2 as a mediator of NRAS-mutant melanoma development that acts through the PI3K/PTEN/Akt pathway to regulate gene expression of a cell cycle regulator

  9. second messengers activate the Rac1 signal, which sets in motion a cascade whereby PAKs phosphorylate and negatively regulate PREX2 to decrease Rac1 activation.

  10. PREX2 mutants are likely selected in cancer to escape PTEN-mediated inhibition of invasion.

Mouse (Murine) DEP Domain Containing 2 (DEPDC2) Interaktionspartner

  1. complex signaling mechanisms that involve PREX2, PI3K/AKT/PTEN and downstream epigenetic machinery to deregulate expression of key cell cycle regulators

  2. P-REX2 PH-domain-mediated inhibition of PTEN has a role in regulating insulin (zeige INS ELISA Kits) sensitivity and glucose homeostasis

  3. This study demonistrated that the P-Rex2, a GEF (zeige ARHGEF2 ELISA Kits) that specifically activates Rac (zeige AKT1 ELISA Kits) small GTPases, is expressed in a cell- and synapse-specific manner in the retina.

  4. PI3K/P-Rex/Rac (zeige AKT1 ELISA Kits) pathway is required for late phase long-term potentiation in the mouse cerebellum

  5. P-Rex1 (zeige PREX1 ELISA Kits) and P-Rex2 are important regulators of Purkinje cell morphology and cerebellar function

DEP Domain Containing 2 (DEPDC2) Antigen-Profil

Beschreibung des Gens

Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase (By similarity).

Genbezeichner und Symbole assoziert mit DEPDC2

  • phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 (PREX2) Antikörper
  • phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 (Prex2) Antikörper
  • 6230420N16Rik Antikörper
  • AI316880 Antikörper
  • AI553603 Antikörper
  • C030045D06Rik Antikörper
  • D430013K02 Antikörper
  • DEP.2 Antikörper
  • Depdc2 Antikörper
  • P-Rex2 Antikörper

Bezeichner auf Proteinebene für DEPDC2

DEP domain-containing protein 2 , PtdIns(3,4,5)-dependent Rac exchanger 2 , phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein , DEP domain containing 2 , ptdIns(3,4,5)-dependent Rac exchanger 2

GENE ID SPEZIES
80243 Homo sapiens
109294 Mus musculus
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