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May be involved in Rab6-mediated GTPase signaling..
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identification of an epileptic encephalopathy additionally featuring cerebral calcifications and coarse facial features caused by recessive loss-of-function mutations in DENND5A
A RUN Domain from DENND5/Rab6IP1 binds sorting Nexin 1 (zeige SNX1 Antikörper) and is involved in the trafficking of vesicles at the level of Golgi.
crystal structure of Rab6a (zeige RAB6A Antikörper)(GTP (zeige AK3 Antikörper)) in complex with a 378-residue internal fragment of the effector Rab6IP1 was solved at 3.2 angstroms resolution. This Rab6IP1 region encompasses an all alpha-helical RUN domain followed in tandem by a PLAT (zeige PLAT Antikörper) domain
In contrast to wild-type R6IP1-Rab6 crystals, which took several weeks to grow to full size, the engineered R6IP1 (RPdel)-Rab6 crystals could be grown in a matter of days
May couple Rab6 and Rab11 function throughout the cell cycle; R6IP1 overexpression alters the distribution of peripheral recycling endosomes.
May be involved in Rab6-mediated GTPase signaling.
DENN domain-containing protein 5A
, RAB6 interacting protein 1
, rab6-interacting protein 1
, Rab6 interacting protein 1