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The protein encoded by DCP2 is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). Zusätzlich bieten wir Ihnen DCP2 Antikörper (58) und viele weitere Produktgruppen zu diesem Protein an.
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ERK (zeige EPHB2 Proteine)-phosphorylated Dcp1a (zeige DCP1A Proteine) enhances its interaction with the decapping enzyme (zeige DCP1A Proteine) Dcp2 during early differentiation of 3T3-L1 cells.
Recruitment of DCP1A (zeige DCP1A Proteine) and DCP2 increases the mRNA degradation capacity of the maturing oocyte so that by the 2-cell stage, most of the maternal mRNA is degraded.
The results showed that DCP1A (zeige DCP1A Proteine) and DCP2 are critical in the transition from mRNA stability to instability during meiotic maturation and that mRNA degradation must be successful to execute the oocyte-to-zygote transition.
In this study the increase in Irf-7 (zeige IRF7 Proteine) mRNA within the background of reduced Dcp2 levels was attributed to a stabilization of the Irf-7 (zeige IRF7 Proteine) mRNA, suggesting that Dcp2 normally modulates Irf-7 (zeige IRF7 Proteine) mRNA stability.
Like Dcp2, Nudt16 (zeige NUDT16 Proteine) also regulates the stability of a subset of mRNAs including a member of the motin family of proteins involved in angiogenesis.
Human Dcp2 levels and activity are controlled by a competition between decapping complex assembly and Dcp2 degradation.
The data indicates that DCP2 activation by DCP1 (zeige ACE Proteine) occurs preferentially on the EDC4 (zeige EDC4 Proteine) scaffold, which may serve to couple DCP2 activation by DCP1 (zeige ACE Proteine) with 5'-to-3' mRNA degradation by XRN1 (zeige XRN1 Proteine) in human cells.
Data show that Y14 (zeige RBM8A Proteine) interacts directly with the decapping factor Dcp2 and the 5' cap structure of mRNAs via different but overlapping domains.
PNRC2 (zeige PNRC2 Proteine) acts in synergy with Dcp1a (zeige DCP1A Proteine) to stimulate the decapping activity of Dcp2 by bridging the interaction between Dcp1a (zeige DCP1A Proteine) and Dcp2.
an mRNA decapping enzyme (zeige DCPS Proteine) demonstrated to contain intrinsic decapping activity
Human Dcp2 is a catalytically active mRNA decapping enzyme (zeige DCPS Proteine) that localizes to the cytoplasm
LSm1 (zeige LSM1 Proteine)-7 proteins colocalize with DCP1 (zeige ACE Proteine),DCP2 and Xrn1 (zeige XRN1 Proteine) in cytoplasmic foci
These data support the novel notion of the association between Ro52 (zeige TRIM21 Proteine) with hDCP2 protein in cytoplasmic p-bodies, playing a role in mRNA metabolism in response to cellular stimulation.
The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
mRNA-decapping enzyme 2
, DCP2 decapping enzyme homolog
, m7GpppN-mRNA hydrolase
, nudix (nucleoside diphosphate linked moiety X)-type motif 20