D-2-Hydroxyglutarate Dehydrogenase Proteine (D2HGDH)

D2HGDH encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. Zusätzlich bieten wir Ihnen D2HGDH Antikörper (25) und D2HGDH Kits (7) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
D2HGDH 98314 Q8CIM3
D2HGDH 301624  
D2HGDH 728294 Q8N465
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Top D2HGDH Proteine auf antikoerper-online.de

Showing 8 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Escherichia coli (E. coli) REACT_Acidaminococcus fermentans Unkonjugiert   50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$285.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
Hefe Zebrafisch His tag   500 μg Anmelden zum Anzeigen 60 bis 71 Tage
$962.50
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,371.50
Details
Hefe Arabidopsis thaliana His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,393.50
Details
Escherichia coli (E. coli) Human S tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$672.00
Details

D2HGDH Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Rat (Rattus)

Human , ,
, ,

Weitere Proteine zu D-2-Hydroxyglutarate Dehydrogenase (D2HGDH) Interaktionspartnern

Human D-2-Hydroxyglutarate Dehydrogenase (D2HGDH) Interaktionspartner

  1. D2HGDH-GAL3ST2 (zeige GAL3ST2 Proteine) is more frequently seen in prostate cancer samples, and seems to be enriched in African Americans.

  2. D2HGDH elevates alpha-KG levels via IDH2 (zeige IDH2 Proteine) expression modulation, influencing histone and DNA methylation (zeige HELLS Proteine), and HIF1alpha (zeige HIF1A Proteine) hydroxylation. D2HGDH mutants found in diffuse large B-cell lymphoma are enzymatically inert.

  3. D2HGDH mutation is not associated with glioblastoma.

  4. We did not find evidence for mutations in the genes D2HGDH and L2HGDH (zeige L2HGDH Proteine) as an alternative mechanism for raised 2-hydroxyglutarate levels in brain tumours

  5. Two novel pathogenic mutations in D-2-hydroxyglutarate dehydrogenase gene in patient with a mild presentation and asymptomatic siblings with D-2-hydroxyglutaric aciduria with a splice error (IVS4-2A-->G) and a missense mutation (c.1315A-->G;p.Asn439Asp).

  6. This enzyme assay will have utility in differentiating patients with 2-hydroxyglutaric aciduria and in assessing the residual activities linked to pathogenic mutations in the D2HGDH gene

D2HGDH Protein Überblick

Protein Überblick

This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.

Genbezeichner und Symbole assoziert mit D2HGDH

  • D-2-hydroxyglutarate dehydrogenase (D2hgdh)
  • D-2-hydroxyglutarate dehydrogenase (D2HGDH)
  • D-2-hydroxyglutarate dehydrogenase (d2hgdh)
  • AA408776 Protein
  • AA408778 Protein
  • AI325464 Protein
  • D2HGD Protein
  • RGD1307976 Protein
  • zgc:158661 Protein

Bezeichner auf Proteinebene für D2HGDH

D-2-hydroxyglutarate dehydrogenase, mitochondrial

GENE ID SPEZIES
98314 Mus musculus
301624 Rattus norvegicus
728294 Homo sapiens
533003 Bos taurus
565889 Danio rerio
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