Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 Proteine (CYP2A6)

CYP2A6, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. Zusätzlich bieten wir Ihnen CYP2A6 Antikörper (113) und CYP2A6 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CYP2A6 1548 P11509
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$340.00
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$888.80
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CYP2A6 Proteine nach Spezies und Herkunft

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Human , ,
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Weitere Proteine zu Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6) Interaktionspartnern

Human Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6) Interaktionspartner

  1. The frequency of slow metabolizers CYP2A6*2 and CYP2A6*9 are poor in the studied Egyptian population. Study findings did not suggest any association between CYP2A6 genotypes and risk of lung cancer in Egyptian population.

  2. Plasma levels of letrozole and CYP2A6 genotype were not significantly associated with a change in pain score from baseline. CYP2A6 genotype was a significant predictor of letrozole plasma levels, but was not associated with the development of arthralgia.

  3. Results identified a significant association between CYP2A6 rs113288603 and hearing loss symptoms and confirm the role of tobacco smoking in age-related hearing loss mediated by CYP2A6.

  4. The aim of this study was to investigate the effects of the interaction between the CYP 2A6 and COMT genes on smoking behavior in young Taiwanese men. The odds ratio for starting smoking was significantly lower in subjects carrying a CYP2A6 low activity/variant COMT rs4680 genotype than in those possessing a CYP2A6 wild-type/variant COMT rs4680 genotype (0.44, 95% confidence interval = 0.19-0.98, P = 0.043).

  5. genetic association studies in population in China: Data suggest that SNPs in CYP2C9 and CYP2A6 are associated with hepatotoxicity due to antiepileptic drug valproate in the population studied. (CYP2C9 = cytochrome P450 family 2 subfamily C member 9; CYP2A6 = cytochrome P450 family 2 subfamily A member 6)

  6. Our results demonstrated the presence of functional variability in CYP2a6 activities resulting from amino acid substitutions caused by genetic polymorphisms.

  7. Cynomolgus monkey CYP2A24, which shows 95% amino acid identity to human CYP2A6.

  8. CYP2A6 rs60823196 and rs138978736 are possible risk factors for serious toxicity in Chinese gastric carcinoma patients treated with S-1 plus oxaliplatin chemotherapy.

  9. findings suggest that CYP1A2 alleles or haplotypes were not predictive of metabolic phenotypes in the Nigerian population; carriers of CYP2A6*9/*17 genotype are likely to be poor metabolisers of CYP2A6 substrates and may experience adverse reactions or poor efficacy while using drugs metabolised mainly by CYP2A6

  10. Genetic polymorphisms in CYP2B6 and CYP2A6 explained a significant proportion of variability in EFV plasma concentration in HIV-infected children in a multi-ethnic outpatient clinic.

  11. In a Mexican Mestizo population, rs1137115(A) and rs4105144(T) in CYP2A6 are associated with cigarette consumption

  12. CYP2B6/CYP2A6 genotypes were associated with increased reported suicidality among AIDS patients who had been randomly assigned to receive efavirenz-containing regimens in clinical trials. Strength of association varied by race/ethnicity.

  13. The CYP2A6 gene product plays a major role in the nicotine metabolism pathway, which influences nicotine intake.

  14. CYP2A6 activity provides information on lung cancer risk that is not captured by smoking history.

  15. CYP2A6*4 genetic polymorphisms may not strongly affect smoking behavior but may possibly have an effect on nicotine dependence

  16. CYP2A6 genetic variation alters striatal-cingulate circuits, network hubs, and executive processing in smokers. Because the CYP2A6 effect was seen only in smokers, these data suggest that the rate of nicotine metabolism-and thus the concentration of nicotine presented to the brain over the course of nicotine addiction-shapes brain circuits that, among other functions, compute reward and impulsivity processes.

  17. a greater CYP2A6 activity causes smokers to smoke more extensively and be exposed to higher levels of carcinogens, resulting in an increased risk for lung cancer.

  18. Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype

  19. We conducted a genome-wide association study (GWAS) of plasma caffeine, paraxanthine, theophylline, theobromine and paraxanthine/caffeine ratio. A single SNP at 6p23 (near CD83) and several SNPs at 7p21 (near AHR), 15q24 (near CYP1A2) and 19q13.2 (near CYP2A6) met GW-significance (P < 5 x 10-8) and were associated with one or more metabolites

  20. study demonstrated a strong dose-dependent association between reduced CYP2A6 activity determined by genotypes and reduced risk of lung cancer

CYP2A6 Protein Überblick

Protein Überblick

This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3\; however, it has been renamed CYP2A6.

Genbezeichner und Symbole assoziert mit CYP2A6

  • cytochrome P450 family 2 subfamily A member 6 (CYP2A6)
  • cytochrome P450 2A6 (CYP2A6)
  • cytochrome P450 family 2 subfamily A member 6 L homeolog (cyp2a6.L)
  • CPA6 Protein
  • CYP2A Protein
  • CYP2A3 Protein
  • cyp2a6 Protein
  • CYPIIA6 Protein
  • P450C2A Protein
  • P450PB Protein

Bezeichner auf Proteinebene für CYP2A6

1,4-cineole 2-exo-monooxygenase , coumarin 7-hydroxylase , cytochrome P450 2A6 , cytochrome P450 IIA3 , cytochrome P450(I) , cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6 , flavoprotein-linked monooxygenase , xenobiotic monooxygenase , cytochrome P450 2A13 , cytochrome P-450 , cytochrome P450 family 2 subfamily A member 6 L homeolog , cytochrome P450, family 2, subfamily A, polypeptide 6

GENE ID SPEZIES
1548 Homo sapiens
100568289 Ovis aries musimon
100036770 Xenopus laevis
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