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CDA encodes an enzyme involved in pyrimidine salvaging. Zusätzlich bieten wir Ihnen CDA Antikörper (83) und CDA Kits (15) und viele weitere Produktgruppen zu diesem Protein an.
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The observed incomplete sister chromatid disjunction may be due to the accumulation of unreplicated DNA during mitosis in CDA-deficient cells, as reflected in the changes in centromeric DNA structure associated with the decrease in basal PARP-1 (zeige PARP1 Proteine) activity.
Intracerebral microdialysis revealed that clonal NSC line to stably express cytosine deaminase (CD-NSCs) produced 5-FU locally in the brain in a 5-FC dose-dependent manner. Collectively, our results from this first-in-human study demonstrate initial safety and proof of concept regarding the ability of NSCs to target brain tumors and locally produce chemotherapy.
results indicate that rs2072671 in CDA may be an important prognostic marker in NK-AML (zeige RUNX1 Proteine) patients.
tumor cell lines that are susceptible to epigenetic nucleosides overexpress cytidine deaminase (CDA); CDA converts 5hmdC and 5fdC into variants of uridine that are incorporated into DNA, resulting in accumulation of DNA damage, and ultimately, cell death
RNA expression of deoxycytidine kinase (DCK (zeige DCK Proteine)), human equilibrative nucleoside transporter-1 (ENT1 (zeige SLC29A1 Proteine)) and ribonucleotide reductase M1 (RRM1 (zeige RRM1 Proteine)) were significantly higher and cytidine deaminase (CDA) was significantly lower in ex vivo Ara (zeige FOXC1 Proteine)-C sensitive samples.
stimulation of PARP-1 (zeige PARP1 Proteine) activity in CDA-deficient cells restores replication and, thus, chromosome segregation. Moreover, increasing intracellular dCTP levels generates under-replication-induced sister-chromatid bridges as efficiently as PARP-1 (zeige PARP1 Proteine) knockdown
n the multivariate Cox (zeige COX8A Proteine) regression analysis, we found that age at diagnosis, wild-type genotype of the CDA A79C polymorphism, and wild-type genotype of the dCK (zeige DCK Proteine) C360G polymorphism were the most significant prognostic factors for predicting the risk of death
Single nucleotide polymorphisms in cytidine deaminase gene were associated with the efficacy of gemcitabine in Biliary Tract Cancer.
Polymorphisms in ABCB1 (zeige ABCB1 Proteine), CDA, ENOSF1 (zeige ENOSF1 Proteine),and TYMS (zeige TYMS Proteine) could help to predict specific and overall severe adverse reactions to capecitabine.
miR (zeige MLXIP Proteine)-484-modulated cytidine deaminase has a dual impact in promoting chemoresistance and suppressing cell proliferation in breast cancer
Data indicate that a combination cytosine deaminase (CDA)/uracil phosphoribosyltransferase (zeige UPP Proteine) protein (UPRT (zeige UPRT Proteine))-expressing adipose tissue-derived mesenchymal stem cells (AT-MSCs) with lysomustine has a superior antitumor effect in the lung carcinoma model compared to monotherapies with transfected AT-MSCs or lysomustine alone.
Activation-induced cytidine deaminase (zeige AICDA Proteine) plays an important role in the containment of autoimmune diseases by negative regulation of autoreactive B cells.
This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.
, CytiDine Deaminase family member (cdd-1)
, CytiDine Deaminase family member (cdd-2)
, cytidine aminohydrolase
, cytosine nucleoside deaminase
, small cytidine deaminase