Cyt-b5, Proteine (CYT-B5)

The protein encoded by CYT-B5 is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Zusätzlich bieten wir Ihnen Cyt-b5, Antikörper (49) und Cyt-b5, Kits (16) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CYT-B5 1528 P00167
Ratte CYT-B5 CYT-B5 64001 P00173
Maus CYT-B5 CYT-B5 109672 P56395
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human GST tag Cytochrome B5 Type A (Microsomal) (CYB5A) (AA 2-97), (partial) protein (GST tag) 50 μg Anmelden zum Anzeigen 13 bis 16 Tage
Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 4 Days
Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Anmelden zum Anzeigen 8 bis 11 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
Escherichia coli (E. coli) Human GST tag 50 μg Anmelden zum Anzeigen 11 Days

CYT-B5 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
, ,

Weitere Proteine zu Cyt-b5, (CYT-B5) Interaktionspartnern

Human Cyt-b5, (CYT-B5) Interaktionspartner

  1. A homodimer model can resolve the conundrum as to how cytochrome P450 oxidoreductase (zeige TXNRD1 Proteine) and cytochrome b5 (zeige CYB5A Proteine) compete for the same binding site on cytochrome P450c17 (zeige CYP17A1 Proteine). (Review)

  2. Data suggest CYP17A1 (zeige CYP17A1 Proteine), with electron donor NADPH-P450 reductase (zeige POR Proteine), is inherently distributive enzyme but that some processivity is present; some 17alpha-hydroxy pregnenolone formed does not dissociate from CYP17A1 (zeige CYP17A1 Proteine) before conversion to dehydroepiandrosterone; CYB5A (zeige CYB5A Proteine) does not enhance reaction by decreasing k(off) of ligands of CYP17A1 (zeige CYP17A1 Proteine). (CYP17A1 (zeige CYP17A1 Proteine) = cytochrome P450, family 17, subfamily A, polypeptide 1; CYB5A (zeige CYB5A Proteine) = cytochrome b5 (zeige CYB5A Proteine))

  3. Data suggest that cytochrome b5 (CYB5 (zeige CYB5A Proteine)) and cytochrome b5 reductase 3 (CYB5R3 (zeige CYB5R3 Proteine)) can reduce human cytoglobin (CYGB (zeige CYGB Proteine)) and zebrafish cytoglobins at rates up to 250-fold higher than those reported for the known physiological substrates, hemoglobin (zeige HBB Proteine) and myoglobin (zeige MB Proteine); the three proteins (CYB5 (zeige CYB5A Proteine)+CYB5R3 (zeige CYB5R3 Proteine)+CYGB (zeige CYGB Proteine)) appear to constitute a metabolon involved in generation of nitric oxide.

  4. Thus, although Mn-b5 binds to CYP17A1 (zeige CYP17A1 Proteine), it is unable to enhance the lyase reaction, strongly suggesting that cyt b5 has a redox effector role in enhancement of the CYP17A1 (zeige CYP17A1 Proteine) mediated lyase reaction necessary for androgen synthesis.

  5. This study constructed a model of the membrane-bound full-length human P450 (zeige CYP2B6 Proteine) 1A2-cyt b5 complex. The model was assembled from several parts using a multiscale modeling approach covering all-atom and coarse-grained molecular dynamics (MD).

  6. We conclude that cytochrome b5 (zeige CYB5A Proteine) can influence the electronic conductivity of cytochrome P450c17 (zeige CYP17A1 Proteine) via allosteric, protein-protein interactions.

  7. Variants in CYB5A (zeige CYB5A Proteine) and CYB5R3 (zeige CYB5R3 Proteine) should be considered in the evaluation of breast cancer risk in African American women.

  8. CYB5A (zeige CYB5A Proteine) is the first RA susceptibility gene involved in androgen synthesis. Our functional analysis of SNP rs1790834 indicates that it contributes to the sex bias observed in RA.

  9. both area and ratio of 3betaHSD (zeige HSD3B1 Proteine) and CYB5A (zeige CYB5A Proteine) double positive cells, which could represent the hybrid cells of zona fasciculate and zona reticularis, are correlated with adrenal development and could influence age-related serum androstenedione levels.

  10. Two acidic residues, Glu (zeige DCTN1 Proteine)-48 and Glu (zeige DCTN1 Proteine)-49, of cytochrome b5 (zeige CYB5A Proteine) are essential for stimulating the 17,20-lyase activity of CYP17A1 (zeige CYP17A1 Proteine).

Cow (Bovine) Cyt-b5, (CYT-B5) Interaktionspartner

  1. the conserved Tyr30 in Cyt b5 is not replaceable due to the presence of both the H-bond network and hydrophobic interaction in the secondary sphere of the heme active site.

  2. The study computes electron transfer rates for the [myoglobin (zeige MB Proteine)(wt), cytochrome b5 (zeige CYB5A Proteine)] complex.

  3. The solution structure of the oxidized cytochrome b(5 (zeige CYB5A Proteine)) mutant V61H.

  4. the effects on the heme microenvironment of cytochrome b(5 (zeige CYB5A Proteine)) caused by the mutation from Val45 to Tyr45, His45 and Glu45

  5. Results from three combined experiments demonstrate that the conserved negatively charged region of cytb5 surrounding the solvent-exposed heme edge is involved in the binding interaction with horse heart cytochrome c (zeige CYCS Proteine).

  6. From a series of site-directed mutations on Cyt b5 this report assesses the contributions of amino acid residues that are expected to influence the docking and electron transfer (ET) between Cyt b5 and horse heart Cyt c (zeige CYCS Proteine).

  7. simulations provided qualitative microscopic explanations of many of the differences in physical properties between outer mitochondrial membrane CYB5 (zeige CYB5A Proteine) isoform and microsomal CYB5 (zeige CYB5A Proteine) and two mutants in terms of localized changes in structure and flexibility

Mouse (Murine) Cyt-b5, (CYT-B5) Interaktionspartner

  1. Demonstration of the physiologic importance of cytochrome b5 (zeige CYB5A Proteine) activating the 17,20-lyase reaction and the production of 19-carbon sex steroids from 21-carbon precursors in mice.

  2. Cytochrome b5 (zeige CYB5A Proteine) and cytokeratin 17 (zeige KRT17 Proteine) are biomarkers in bronchoalveolar fluid signifying onset of acute lung injury.

Rabbit Cyt-b5, (CYT-B5) Interaktionspartner

  1. Data indicate not only that binding of b5 and P450 reductase (zeige POR Proteine) on the proximal surface of P450 (zeige POR Proteine) 2B4 (zeige CD244 Proteine) results in electron transfer but also that each redox partner transmits unique structural information to the active site proton delivery network.

  2. the observation of weak and nonspecific interactions between CYP2B4 and cytb5 in micelles suggests that lipid bilayer structures and low curvature membrane surface are preferable for CYP2B4-cytb5 complex formation.

  3. Data suggest that the cytb5-cytP4502B4 complex structure will help unravel the mechanism by which cytb5 regulates catalysis by cytP4502B4.

  4. Two different types of cytochrome b5 (zeige CYB5A Proteine) orientations are present within a MFO system: the first allowing potential cytochrome b5 (zeige CYB5A Proteine) electron donation to P450 (zeige POR Proteine), the second one inducing cytochrome b5 (zeige CYB5A Proteine) modulation of P450 (zeige POR Proteine) structural changes.

Fruit Fly (Drosophila melanogaster) Cyt-b5, (CYT-B5) Interaktionspartner

  1. Regulation of hemocytes in Drosophila requires dappled cytochrome b5

Cyt-b5, (CYT-B5) Protein Überblick

Protein Überblick

The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit Cyt-b5, Proteine (CYT-B5)

  • cytochrome b5 type A (CYB5A)
  • cytochrome b5 type A (Cyb5a)
  • cytochrome b5 type A (microsomal) (CYB5A)
  • cytochrome b5 type A (microsomal) (Cyb5a)
  • cytochrome b5 (LOC100328915)
  • cytochrome b5 (LOC100735904)
  • Cytochrome b5 (Cyt-b5)
  • cytochrome b5 (CYB5A)
  • 1857 Protein
  • 0610009N12Rik Protein
  • BcDNA:GH02503 Protein
  • BcDNA:RE66521 Protein
  • CG2140 Protein
  • Cyb5 Protein
  • CYB5A Protein
  • CYT-B5 Protein
  • CYTB5 Protein
  • Dmel\\CG2140 Protein
  • dpld Protein
  • l(2)01857 Protein
  • l(2)k00107 Protein
  • MCB5 Protein

Bezeichner auf Proteinebene für Cyt-b5, Proteine (CYT-B5)

cytochrome b5 , type 1 cyt-b5 , cytochrome b-5 , cytochrome b5A microsomal , CG2140-PA , CG2140-PB , Cyt-b5-PA , Cyt-b5-PB , dappled , lethal (2) k00107

1528 Homo sapiens
414798 Gallus gallus
64001 Rattus norvegicus
281110 Bos taurus
109672 Mus musculus
100328915 Oryctolagus cuniculus
100735904 Cavia porcellus
476167 Canis lupus familiaris
35688 Drosophila melanogaster
100861011 Capra hircus
Ausgewählte Anbieter für Cyt-b5, Proteine (CYT-B5)
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