The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009].
Gegunde, Alfonso, Alvariño, Alonso, Botana: "Cyclophilins A, B, and C Role in Human T Lymphocytes Upon Inflammatory Conditions." in: Frontiers in immunology, Vol. 12, pp. 609196, (2021) (PubMed).
Ray, Sullenger, White: "Further characterization of the target of a potential aptamer biomarker for pancreatic cancer: cyclophilin B and its posttranslational modifications." in: Nucleic acid therapeutics, Vol. 23, Issue 6, pp. 435-42, (2013) (PubMed).
Aliase für PPIB Proteine
peptidylprolyl isomerase B (ppib) Proteine peptidylprolyl isomerase B (PPIB) Proteine peptidylprolyl isomerase B (Ppib) Proteine peptidylprolyl isomerase B (CC1G_03223) Proteine peptidylprolyl isomerase B (cyclophilin B) (Ppib) Proteine peptidylprolyl isomerase B L homeolog (ppib.L) Proteine peptidylprolyl isomerase B (cyclophilin B) (PPIB) Proteine peptidylprolyl isomerase B (cyclophilin B) (ppib) Proteine AA408962 Proteine AA553318 Proteine ACYPI004891 Proteine AI844835 Proteine cb87 Proteine Cphn-2 Proteine Cphn2 Proteine CyP-20b Proteine cyp-s1 Proteine CYP-S1 Proteine cypb Proteine CypB Proteine CYPB Proteine OI9 Proteine PPIB Proteine Ppib Proteine sb:cb87 Proteine scylp Proteine Scylp Proteine SCYLP Proteine wu:fa97f08 Proteine zgc:73214 Proteine zgc:86796 Proteine