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The protein encoded by CDK2AP1 is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. Zusätzlich bieten wir Ihnen Cyclin-Dependent Kinase 2 Associated Protein 1 Proteine (12) und Cyclin-Dependent Kinase 2 Associated Protein 1 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 53 products:
Human Polyclonal CDK2AP1 Primary Antibody für IHC, IHC (p) - ABIN4305761
Dieterich, Mellberg, Langenkamp, Zhang, Zieba, Salomäki, Teichert, Huang, Edqvist, Kraus, Augustin, Olofsson, Larsson, Söderberg, Molema, Pontén, Georgii-Hemming, Alafuzoff, Dimberg: Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization. in The Journal of pathology 2012
Cdk2ap1 expression is primarily regulated by progesterone and the progesterone receptor (zeige PGR Antikörper) in uterus and is mainly localized to proliferating tissues.
Results indicate that DOC-1 (zeige CA6 Antikörper) is a bona fide subunit of the Mi-2 (zeige CHD4 Antikörper)/NuRD chromatin remodeling complex.
(CDK2 (zeige CDK2 Antikörper)-AP1 (zeige JUN Antikörper)) is a potential gene therapeutic agent for oral/head and neck cancer in conjunction with DNA-damaging agents such as cisplatin.
p12CDK2-AP1 (zeige JUN Antikörper) forms nuclear homodimers in contact inhibited normal diploid cells and dimerization of p12 is a necessary process for the growth inhibition effect by p12
Results suggest that overexpression of CDK2 (zeige CDK2 Antikörper)-associating protein 1 (p12CDK2AP1) leads to testicular and ovarian abnormalities, a phenotype closely related to that of cdk2 (zeige CDK2 Antikörper)-/- mice.
Cdk2ap1, a negative regulator of Cdk2 (zeige CDK2 Antikörper) function and cell cycle, promotes Oct4 (zeige POU5F1 Antikörper) promoter methylation during murine embryonic stem cell differentiation to down-regulate Oct4 (zeige POU5F1 Antikörper) expression.
Cdk2ap1 plays an essential role in the early stage of embryogenesis and has a potential role during craniofacial morphogenesis.
CDK2AP1-mediated differentiation of murine embryonic stem cell was elicited through the regulation of pRb (zeige PGR Antikörper).
The simultaneous overexpression of p12CDK2-AP1 (zeige FOSB Antikörper) and CD82 (zeige CD82 Antikörper) significantly suppressed the in vivo tumor growth.
knockdown of CDK2AP1 in primary human fibroblasts reduced proliferation and induced premature senescence, with the observed phenotype being p53 (zeige TP53 Antikörper) dependent
In summary, p12CDK2AP1 expression in myxofibrosarcoma cells induces G0/G1 arrest and mitochondria dependent proapoptotic activity and down-regulation of p12CDK2AP1 by shRNAi results in up-regulation of the CDK2 (zeige CDK2 Antikörper) transcript and protein.
Study reports that knockdown of CDK2AP1 by RNAi in glioma cells could effectively inhibit cell proliferation by inducing cell cycle arrest and apoptosis
CDK2AP1 plays an important role in modulating the growth and tumorigenesis of lung cancer cells.
Low CDK2AP1 expression is common and associated with adverse prognosis in nasopharyngeal carcinoma.
Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-terminal region
In comparison with the healthy gingiva, the expression of Doc-1 was decreased, whereas the expression of S100A7 (zeige S100A7 Antikörper) was upregulated in all oral lesions.
P12(CDK2AP1) is downregulated by miR (zeige MLXIP Antikörper)-21
Missing down-regulation of the tumor-suppressor gene DOC-1, might exert protective effects and counteract malignant transformation of benign, proliferating lesions of the oral cavity.
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
cyclin-dependent kinase 2 associated protein 1
, CDK2-associated protein 1
, CDK2 (cyclin-dependent kinase 2)-associated protein 1
, cyclin-dependent kinase 2-associated protein 1
, CDK2-associated protein1
, deleted in oral cancer 1
, putative oral cancer suppressor
, Deleted in oral cancer-1