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CCNF encodes a member of the cyclin family. Zusätzlich bieten wir Ihnen Cyclin F Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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A single missense mutation in cyclin F causes hyper-ubiquitylation of proteins that can indirectly impair the autophagy degradation pathway, which is implicated in amyotrophic lateral sclerosis pathogenesis.
Cyclin F and ribonucleotide reductase family member 2 (RRM2 (zeige RRM2 Antikörper)) compose a functional axis responsible for nucleotide metabolism. Impairment in this pathway may contribute to increased DNA damage repair and drug resistance. Additionally, we analyzed the expression of RRM2 (zeige RRM2 Antikörper) mRNA and discovered that high expression of RRM2 (zeige RRM2 Antikörper) is associated with worse overall survival.
Mutational spectrum of CCNF emphasizes the pathogenic role of CCNF mutations in ALS.
Our result indicates that the mutation of CCNF is rare in patients with amyotrophic lateral sclerosis and frontotemporal dementia from Mainland China
These data indicate that the coordinated, temporal ordering of cyclin F and Cdh1 (zeige CDH1 Antikörper) degradation, organized in a double-negative feedback loop, represents a fundamental aspect of cell-cycle control
Authors demonstrated a significant correlation between the severity of the CCNF-induced axonopathy and a reduced motor response to a light stimulus (photomotor response).
Cyclin F-mediated degradation of SLBP (zeige SLBP Antikörper) limits H2A.X (zeige H2AFX Antikörper) accumulation and apoptosis upon genotoxic stress in G2 cell cycle checkpoint.
cyclin F is a novel F-box protein (zeige FBXW10 Antikörper) that functions as an intrinsic cellular regulator of HIV-1 Vif (zeige BTG1 Antikörper) and has a negative regulatory effect on the maintenance of viral infectivity by restoring APOBEC3G (zeige APOBEC3G Antikörper) expression
The SCYL1- BP1 (zeige GORAB Antikörper) affects the cell cycle through increasing steady state levels of Cyclin F and RRM2 (zeige RRM2 Antikörper) proteins, thus constituting a dual regulatory circuit.
Data indicate that a missense mutation in cyclin F (CCNF) in a large Amyotrophic lateral sclerosis (ALS (zeige IGFALS Antikörper)) and frontotemporal dementia (FTD (zeige FTL Antikörper)) family.
SCF (zeige KITLG Antikörper)(Cyclin F)-mediated degradation of CP110 (zeige CCP110 Antikörper) is required for the fidelity of mitosis and genome integrity
CycF(-/-) animals, with a myriad of developmental anomalies due in large part to failures in yolk sac (zeige ADCY10 Antikörper) and chorioallantoic placentation, die around embryonic day 10.5.
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified.
, cyclin F
, G2/mitotic-specific cyclin-F
, G2/mitotic-specific cyclin-F-like
, g2/mitotic-specific cyclin-F-like
, F-box only protein 1