Crystallin, alpha B (CRYAB) ELISA Kits

Human Crystallin, alpha B (CRYAB) Interaktionspartner

1. alphaB-crystallin mutants carrying point substitutions in the C-terminal domain

2. Heparan sulfate mediates cell uptake of alphaB-crystallin fused to the glycoprotein C (zeige MUC15 ELISA Kits) cell penetration peptide

3. Our findings suggest that serum level of miR (zeige MLXIP ELISA Kits)-491 has potential as a biomarker for predicting OS progression and prognosis of OS patients. miR (zeige MLXIP ELISA Kits)-491 exerts its role by directly targeting alphaB-crystallin (CRYAB) in OS.

4. A missense mutation (p.D109G) in CRYAB causes restrictive cardiomyopathy (RCM (zeige Unc5c ELISA Kits)).

5. Using a combination of co-sedimentation centrifugation, viscometric assays and electron microscopy of negatively stained filaments to analyse the in vitro assembly of desmin (zeige DES ELISA Kits) filaments, this study shows that the binding of CRYAB to desmin (zeige DES ELISA Kits) is subject to its assembly status, to the subunit organization within filaments formed and to the integrity of the C-terminal tail domain of desmin (zeige DES ELISA Kits).

6. Overexpression of both HSPB5 and Hsp27 significantly reduced the intracellular aggregation of alpha-synuclein.

7. Glutathione-S-transferase (zeige GSTa2 ELISA Kits) - HspB1 (zeige HSPB1 ELISA Kits) fusion protein prevents more aggregation of malate dehydrogenase compared to glutathione-S-transferase (zeige GSTa2 ELISA Kits) -HspB5 fusion protein and wild type HspB1 (zeige HSPB1 ELISA Kits).

8. Mechanistic studies revealed KLF4 (zeige KLF4 ELISA Kits) specifically bound the promoter of CRYAB and upregulated CRYAB expression in human osteosarcoma cells.

9. mRNA levels of HSP family members (HSP70B', HSP72 (zeige HSPA1A ELISA Kits), HSP40/DNAJ (zeige DNAJB1 ELISA Kits), and HSP20 (zeige HSPB6 ELISA Kits)/CRYAB) are upregulated by the intracellular MMP3 (zeige MMP3 ELISA Kits) overload.

10. HspB5 maybe trigger the epithelial-mesenchymal transition in colorectal cancer (CRC (zeige CALR ELISA Kits)) by activating the ERK (zeige EPHB2 ELISA Kits) signaling pathway. It is a potential tumor biomarker for CRC (zeige CALR ELISA Kits) diagnosis and prognosis.

Mouse (Murine) Crystallin, alpha B (CRYAB) Interaktionspartner

1. findings offer additional insight into the early transcriptional changes caused by Cryaa (zeige CRYAA ELISA Kits) and Cryab mutations associated with autosomal dominant cataracts, and indicate that the transcript levels of certain genes are affected by the expression of mutant alpha-crystallin in vivo

2. desmin and alphaBeta-crystallin are localized at sarcoplasmic reticulum (SR)-mitochondria-associated membranes (MAMs), where they interact with VDAC, Mic60 - the core component of mitochondrial contact site and cristae organizing system (MICOS) complex - and ATP synthase, suggesting that these associations could be crucial in mitoprotection at different levels.

3. This study demonstrated that HspB5 mRNA localization in myelin-enriched white and gray matter

4. alphaB-crystallin is an important regulator of epithelial-mesenchymal transition, acting as a molecular chaperone (zeige HSP90AA1 ELISA Kits) for SMAD4 (zeige SMAD4 ELISA Kits) and as its potential therapeutic target for preventing subretinal fibrosis development in neovascular age-related macular degeneration

5. It is a non-Hsp gene, which is essential for HSF1 (zeige HSF1 ELISA Kits)-mediated maintenance of whole body homeostasis.

6. A previously unrecognized link between c-Jun (zeige JUN ELISA Kits) and Nrf2 (zeige NFE2L2 ELISA Kits) transcription factors and redox-induced CRYAB expression in muscle cells.

7. CryAB protects decidualization against stress conditions.

8. TNF-alpha (zeige TNF ELISA Kits)-induced endothelial adhesion molecule (zeige NCAM1 ELISA Kits) expression is reduced in inflamed vessels of alphaB-crystallin deficient mice, and leukocyte rolling velocity and IkappaB levels are increased.

9. Study shows that overexpression of Bcl-2 (zeige BCL2 ELISA Kits) is sufficient to reduce the levels and overall architecture of protein deposition in the transgenic CryABR120G/Bcl-2 (zeige BCL2 ELISA Kits) hearts.

10. alphaB-crystallin is over-expressed in fibrotic lung tissue and favors TGF-beta1 (zeige TGFB1 ELISA Kits) pathway via its role in modulating the cellular localization of Smad4 (zeige SMAD4 ELISA Kits).

Cow (Bovine) Crystallin, alpha B (CRYAB) Interaktionspartner

1. The alphaB-crystallin content of bovine type I muscle fibers is quantitatively similar to that in the predominantly type I fibers of rat soleus muscle.

2. In the presence of alpha-crystallin or GroEL the kinetic of GAPDH (zeige GAPDH ELISA Kits) aggregation is changed from the diffusion-limited cluster-cluster aggregation to the reaction-limited cluster-cluster aggregation.

3. one of the functions of alphaB-crystallin is to bind microtubules via microtubule binding proteins and to give the MTs (zeige NEU2 ELISA Kits) resistance to disassembly

4. The study provides evidence for the regulation of the chaperone activity of alphaB-crystallin by phosphorylation and indicates that this may play an important role in alleviating the pathogenic effects associated with protein conformational diseases.

Pig (Porcine) Crystallin, alpha B (CRYAB) Interaktionspartner

1. This study clearly demonstrated that both the length and electrostatic charge of the COOH-terminal segment play crucial roles in governing the structural stability and chaperone activity of alphaB-crystallin.