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The protein encoded by CNTN1 is a member of the immunoglobulin superfamily. Zusätzlich bieten wir Ihnen Contactin 1 Antikörper (76) und Contactin 1 Kits (61) und viele weitere Produktgruppen zu diesem Protein an.
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Human Contactin 1 Protein expressed in Human Cells - ABIN2002736
Peles, Nativ, Campbell, Sakurai, Martinez, Lev, Clary, Schilling, Barnea, Plowman, Grumet, Schlessinger: The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin. in Cell 1995
Show all 5 Pubmed References
CNTN-1 promotes cisplatin resistance in human cisplatin-resistant lung adenocarcinoma through inducing the Epithelial-Mesenchymal Transition process by activating the PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling pathway.
CNTN1 is a new gene which can be regulated by RET (zeige RET Proteine)/PTC3 (zeige NCOA4 Proteine) (Ret proto-oncogene (zeige RET Proteine) and Ret-activating protein ELE1 (zeige NCOA4 Proteine)) rearrangement gene and the protein level of CNTN1 is increasing in thyroid cancer.
Structurally, CASPR2 (zeige CNTNAP2 Proteine) is highly glycosylated and has an overall compact architecture. CASPR2 (zeige CNTNAP2 Proteine) associates with micromolar affinity with CNTN1 but, under the same conditions, it does not interact with any of the other members of the contactin family.
CNTN1 promotes prostate cancer progression.
High CNTN-1 expression is associated with metastasis in gastric cancer.
CNTN-1 is closely related with multidrug resistance of lung adenocarcinoma.
anti-CNTN1 IgG4 antibodies are associated with subacute onset of chronic inflammatory demyelinating polyneuropathy symptoms, sensory ataxia, and good response to corticosteroids.
under hypoxia conditions, elevated HIF-1alpha (zeige HIF1A Proteine) seems to up-regulate contactin-1 expression and by this activate RhoA (zeige RHOA Proteine) and facilitate migration of cancer cells.
activation of AKT (zeige AKT1 Proteine) plays a role in contactin-1-mediated downregulation of E-cadherin (zeige CDH1 Proteine).
A high expression of CNTN1 was markedly associated with the regional lymph node metastasis of patients with oral squamous cell carcinoma.
Data indicate that Contactin-1 expression is dependent upon EBF (zeige EBF1 Proteine) factors; Cntn1 gene belongs to the expanding regulatory cascade driven by these transcriptional regulators so that changes in its activation may contribute to the Ebf2 (zeige EBF2 Proteine) null mutant phenotype
Contactin-1 has roles in regulating myelination and nodal/paranodal domain organization in the central nervous system
The phenotype of the Cntn1 mice arises from dysfunction in the brain, spinal cord or peripheral nervous system.
Data show that TAG1 (zeige CNTN2 Proteine) and F3 act antagonistically to control SHH (zeige SHH Proteine)-induced proliferation: F3 suppresses SHH (zeige SHH Proteine)-induced GNP proliferation and induces differentiation, whereas TAG1 (zeige CNTN2 Proteine) antagonises F3.
these findings indicate that precise spatio-temporal regulation of TAG-1 (zeige CNTN2 Proteine) and F3/contactin expression is critical for normal cerebellar morphogenesis
F3/contactin and caspr/paranodin (zeige CNTNAP1 Proteine) traffic to the cell surface via a non-conventional pathway
These data provide evidence of a role for contactin in selectively regulating the cell surface expression and current densities of TTX-R but not TTX-S Na+ channel isoforms in nociceptive DRG neurons.
Contactin-1 is a functional receptor for neuroregulatory chondroitin sulfate-E.
Thus, our results suggest a contribution by DRG Na(v)1.6, and possibly Contactin to neuropathic pain in the neuroma model in mice.
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, contactin 1
, Neural cell surface protein F3
, glycoprotein gP135
, neural cell surface protein F3
, neural cell recognition molecule F11
, neural cell recognition protein