Cone-Rod Homeobox Proteine (CRX)

The protein encoded by CRX is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. Zusätzlich bieten wir Ihnen Cone-Rod Homeobox Antikörper (64) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CRX 1406 O43186
Ratte CRX CRX 60446  
CRX 12951 O54751
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Xenopus tropicalis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Hund His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

CRX Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
Mouse (Murine)

Am meisten referenzierte Cone-Rod Homeobox Proteine

  1. Human CRX Protein expressed in Wheat germ - ABIN5679752 : Santagata, Maire, Idbaih, Geffers, Correll, Holton, Quackenbush, Ligon: CRX is a diagnostic marker of retinal and pineal lineage tumors. in PLoS ONE 2009 (PubMed)

Weitere Proteine zu Cone-Rod Homeobox (CRX) Interaktionspartnern

Zebrafish Cone-Rod Homeobox (CRX) Interaktionspartner

  1. CRX can influence the development and opsin expression of photoreceptor outer segments in zebrafish.

  2. The CRX protein can recognize the BAT 1 regulatory region contains highly conserved OTX (GATTA) and OTX-like (TATTA) sequences.

  3. No mutation in crx were identified in homozygous mok(m632) or nie(m743). Consistent with the absence of identified mutations, linkage analysis excluded linkage of the mutant phenotypes to crx.

Human Cone-Rod Homeobox (CRX) Interaktionspartner

  1. Mutation in CRX gene is associated with macular dystrophy with intrafamilial variable expressivity.

  2. that two photoreceptor-specific transcription factors, NRL and CRX, are master regulators of this program and are required for tumor maintenance in this subgroup

  3. A novel CRX pathogenic variant has been identified in our patients. The novel pathogenic variant seems to have a different effect on the phenotype of cone-rod dystrophy.

  4. A sensitive and simple method of tumour cell assessment has been developed that can be used in the clinics to assess for potential extraocular dissemination after intravitreal injections to assure its performance.

  5. we revealed a novel frameshift mutation (NM_000554.4:c.538dupG:p.Val180fs) in exon 4 of the CRX gene in a Chinese family with Cone-rod dystrophy. This study broadens the known pathogenic mutation spectrum of the CRX gene and contributes to improved genetic counseling for Cone-rod dystrophy patients.

  6. analysis of a homozygous nonsense mutation in SAMD11 in five individuals diagnosed with adult-onset retinitis pigmentosa; SAMD11 interacts with CRX and is expressed in retina

  7. CRX mutations are associated with a variety of clinical phenotypes, including an adult-onset macular dystrophy that simulates benign concentric annular macular dystrophy with a bull's eye macular lesion and fairly well preserved visual acuity.

  8. data demonstrate the successful application of ZFN technology to generate CRX-GFP labeled hESC lines, which can be used to study and isolate photoreceptor precursors during hESC differentiation.

  9. Loss of OTX2 expression resulted in decreased expression of C-MYC and CRX, genes previously implicated in retinoblastoma tumorigenesis. Loss of OTX2 expression increased the phosphorylation of RB, a potential mechanism of modulating cell proliferation

  10. Mutations involving the CRX gene may demonstrate an autosomal dominant inheritance pattern for leber congenital amaurosis.

  11. Con rod homeobox protein mRNA is a novel marker for retinoblastoma at extraocular sites.

  12. Two de novo mutations in CRX were found in Chinese patients with Leber congenital amaurosis. The CRX mutation might create a dominantly inherited trait.

  13. Mutations in CRX demonstrate significant phenotypic heterogeneity both between and within pedigrees. A novel, adult-onset, macular dystrophy phenotype is characterized, further extending our knowledge of the etiology of dominant macular dystrophies.

  14. CRX could be useful in surgical neuropathology for the differential diagnosis of pineal region tumors, in particular to discriminate pineal tumors from glial tumors

  15. Data have identified a novel retinal SAM domain protein, Samd7, which could act as a transcriptional repressor involved in fine-tuning of Crx-regulated gene expression.

  16. the potential utility of CRX as a marker of pineal lineage in routine diagnostic neuropathology.

  17. In this study, three variations were detected in 3 of 130 families with CORD, including two novel mutations, c.239A>G (p.Glu80Gly) and c.362C>T (p.Ala121Val)

  18. These findings suggest that CRX is a useful marker to discriminate metastatic retinoblastoma from other, more common, malignant small round cell tumors of childhood

  19. Photosensitive photoreceptor cells can be generated by combinations of transcription factors. The combination of CRX and RX generate immature photoreceptors: and additional NEUROD promotes maturation.

  20. Data show no interaction of barrier-to-autointegration factor (BAF) with HIV-1 MA, cone-rod homeobox (Crx) or MAN1-C in absence of DNA.

Cow (Bovine) Cone-Rod Homeobox (CRX) Interaktionspartner

  1. OTR1, OTX2 and CRX act as positive modulators of the BEST1 promoter in the retinal pigment epithelium.

Mouse (Murine) Cone-Rod Homeobox (CRX) Interaktionspartner

  1. Results demonstrate that the activity of CRX binding sites is highly dependent on sequence context, providing insight into photoreceptor gene regulation and illustrating functional principles of homeodomain binding sites that may be conserved in other cell types.

  2. CRX is required for chromatin remodeling at only a subset of its binding sites, which undergo retina or neuronal specific activation during photoreceptor differentiation.

  3. proteins involved in phototransduction were not detected in the Crx(-/-) mouse; in this phenotype, however, proteins from spots showing diurnal rhythms were specifically identified as enzymes involved in glucose metabolism, Krebs cycle, and mitochondrial enzymes.

  4. The L253X mouse provides a valuable model for CRX-associated retinopathy. The pathogenicity of CRX frameshift mutations depends on the position of the premature termination codon, which in turn determines the degree of mutant mRNA/protein overproduction.

  5. CRX-associated retinopathies stem from graded changes in photoreceptor gene expression, which could significantly contribute to phenotypic variability.

  6. Rax and Crx cooperatively transactivate Rhodopsin and cone opsin promoters and an optimum Rax expression level to transactivate photoreceptor gene expression exists.

  7. E168d2 and R90W are mechanistically distinct mouse models for CRX-associated disease that will allow the elucidation of molecular mechanisms and testing of novel therapeutic approaches for different forms of CRX-associated disease.

  8. The rhythmic nature of pineal CRX protein may directly modulate the daily profile of Aanat expression by inducing nighttime expression of this enzyme, facilitating nocturnal melatonin synthesis

  9. We conclude that nucleotide changes in evolutionary conserved crx binding site could impact retina-specific expression levels of Kcnv2.

  10. In Crx-knockout mice vasopressin mRNA expression in the suprachiasmatic nucleus shows significant daily rhythm.

  11. Data have identified a novel retinal SAM domain protein, Samd7, which could act as a transcriptional repressor involved in fine-tuning of Crx-regulated gene expression.

  12. Our results show that NRL and CRX together control the expression of most, if not all, genes involved in rod phototransduction through a cis-regulatory module

  13. Crx broadly modulates the pineal transcriptome and also influences differential night/day gene expression in this tissue

  14. A change in the suprachiasmatic nuclei of the Crx-deficient mouse might explain the observed circadian differences between the knockout mouse and wild-type mouse.

  15. CRX combinatorially orchestrates the transcriptional networks of both rods and cones by coordinating the expression of photoreceptor genes including most retinal disease genes.

  16. Studies isolated Panky/Ankrd33, a gene encoding an ankyrin repeat-containing protein and that PANKY inhibited the DNA-binding activity of CRX.

  17. CRX has a role in retinal and pineal lineage tumors

  18. Crx is expressed very soon after a cell fated to be a photoreceptor cell becomes postmitotic.

  19. the mouse Crx 5'-upstream genomic sequence is capable of directing a cell-specific and developmentally regulated expression of Crx in photoreceptor cells

  20. both Nrl and Crx are required for full transcriptional activity of the PDE6A gene

Cone-Rod Homeobox (CRX) Protein Überblick

Protein Überblick

The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.

Genbezeichner und Symbole assoziert mit Cone-Rod Homeobox Proteine (CRX)

  • cone-rod homeobox (crx)
  • cone-rod homeobox (CRX)
  • cone-rod homeobox (Crx)
  • CORD2 Protein
  • CRD Protein
  • CRX Protein
  • Crx1 Protein
  • LCA7 Protein
  • OTX3 Protein
  • otx5 Protein
  • otx5b Protein
  • rx Protein
  • Xotx5 Protein
  • Xotx5b Protein

Bezeichner auf Proteinebene für Cone-Rod Homeobox Proteine (CRX)

cone-rod homeobox , homeobox protein otx5 , orthodenticle homolog 5 , cone-rod homeobox protein , orthodenticle homeobox 3 , crx gene for cone-rod homeobox protein , photoreceptor-specific cone-rod homeobox protein , cone-rod homeobox containing

81881 Danio rerio
468934 Pan troglodytes
548775 Xenopus (Silurana) tropicalis
554246 Monodelphis domestica
717550 Macaca mulatta
100379624 Felis catus
1406 Homo sapiens
280756 Bos taurus
403577 Canis lupus familiaris
60446 Rattus norvegicus
12951 Mus musculus
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