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COLEC11 encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains.
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High CLK1 (zeige CDK11B Proteine) expression is associated with cardiovascular disease.
The exclusion of the MASP1 (zeige MASP1 Proteine) and COLEC11 Loci in two individuals from different consanguineous families and the absence of mutations in four further individuals sequenced for both genes raises the possibility that that there is further genetic heterogeneity of 3MC syndrome
identify collectin (zeige MBL2 Proteine) CL-LK as a novel soluble C-type lectin (zeige MBL2 Proteine) able to bind M. tuberculosis, and characterize mycobacterial mannose-capped lipoarabinomannan as a primary ligand for CL-LK
Data indicate differences in the plasma concentrations of collectin liver 1 (zeige COLEC10 Proteine) and collectin (zeige MBL2 Proteine) kidney 1 (zeige ZNF354A Proteine), M-ficolin (zeige FCN1 Proteine) and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls.
promoter polymorphism COLEC11-9570C>T (rs3820897) was associated with decreased levels of CL-K1.
the sugar specificity of CL-K1 was established.
These results suggest that specific diseases may affect CL-K1 synthesis in an organ dependent manner and that elevated plasma CL-K1 levels are associated with the presence of DIC.
Most plasma CL-K1 was found in complex with CL-L1 (zeige COLEC10 Proteine) in a ratio suggesting a heteromeric subunit of 1 CL-L1 (zeige COLEC10 Proteine) & 2 CL-K1 polypeptides. It associated with MASPs 1, 2 & 3. On binding mannan or DNA in the presence of MASP-2 (zeige MASP2 Proteine), the complex deposited C4b (zeige C4B Proteine).
Data suggest that collectin 11 (CL-11), e.g. via complement, may play a role in response to particles and surfaces presenting extracellular DNA, such as apopototic cells.
collectin-11 associates with all the known MBL (zeige MBL2 Proteine)-associated serine proteases (MASP-1 (zeige MASP1 Proteine), MASP-2 (zeige MASP2 Proteine) and MASP-3 (zeige MASP1 Proteine)) as well as the lectin complement pathway regulator MAP-1 (zeige MASP1 Proteine).
CL-K1-/- mice revealed decreased phagocytosis of Streptococcus pneumoniae
intrarenal expression of COLEC11 rapidly increases in the postischemic period and colocalizes with complement deposited along the basolateral surface of the proximal renal tubule in association with L-fucose, the potential binding ligand for COLEC11.
identify collectin (zeige MBL2 Proteine) CL-LK as a novel soluble C-type lectin able to bind M. tuberculosis, and characterize mycobacterial mannose-capped lipoarabinomannan as a primary ligand for CL-LK
This profile of CL-K1 expression is unique among the collectins. [CL-K1]
This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
collectin sub-family member 11
, collectin kidney protein 1
, collectin 2