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COL15A1 encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices).
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Collagen XV is required for notochord differentiation and muscle development in the zebrafish embryo and it interplays with Shh (zeige SHH ELISA Kits) signalling.
COL15A1 mRNA was up-regulated in hepatocellular cancer (HCC) and collagen XV was expressed along the sinusoid-like endothelium of HCC but not in non-tumoral regions, which implies that collagen XV contributes to the capillarization of HCC.
we identified an epithelial ovarian cancer susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 x 10(-8))
COL15A1, provide evidence for concomitant epigenetic regulation and genetic susceptibility, and define a class of causal targets that sit at the intersection of genetic and epigenetic predisposition in the etiology of complex disease.
These results suggest genetic variation in COL15A1 and COL18A1 (zeige COL18A1 ELISA Kits) can modify the age of onset of both early and late onset POAG.
Collagen type XV and osteocalcin (zeige BGLAP ELISA Kits) expression are highly sensitive markers to extracellular calcium
the crystal structure of the trimerization domain of human type XV collagen
the primary determinant is the gene specifying collagen XV, a proteoglycan (zeige Vcan ELISA Kits) closely associated with the basement membrane
The neuroprotection observed in ColXV KO mice may be attributed to the increased VEGF-A (zeige VEGFA ELISA Kits) production following stroke in the ischemic territory.
Col (zeige HDAC1 ELISA Kits) XV is necessary for extracellular matrix organization in the heart, and for the structure and functions of microvessels. Col (zeige HDAC1 ELISA Kits) XV deficiency leads to a complex cardiac phenotype and predisposes the subject to pathological responses under cardiac stress.
This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.
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, alpha 1 type XV collagen
, collagen XV alpha 1
, collagen alpha-1(XVIII) chain
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, collagen alpha-1(XV) chain
, collagen alpha-1(XV) chain-like
, collagen XV, alpha-1 polypeptide
, collagen type XV proteoglycan
, procollagen type XV
, procollagen, type XV
, type XV collagen