Collagen, Type XV, alpha 1 (COL15A1) ELISA Kits

Zebrafish Collagen, Type XV, alpha 1 (COL15A1) Interaktionspartner

1. Collagen XV is required for notochord differentiation and muscle development in the zebrafish embryo and it interplays with Shh signalling.

Human Collagen, Type XV, alpha 1 (COL15A1) Interaktionspartner

1. This study identified collagen XV as a new low O2 tension sensitive gene, and provided a novel mechanistic evidence that directly HIF-1alpha (hypoxia-inducible factor-1 alpha) mediates collagen XV expression in response to hypoxia, since it was found specifically in vivo recruited at collagen XV promoter, in hypoxia-preconditioned mesenchymal stromal cells.

2. COL15A1 mRNA was up-regulated in hepatocellular cancer (HCC) and collagen XV was expressed along the sinusoid-like endothelium of HCC but not in non-tumoral regions, which implies that collagen XV contributes to the capillarization of HCC.

3. This study demonstrated that novel role for collagen XV in motor axon pathfinding and neuromuscular development.

4. we identified an epithelial ovarian cancer susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 x 10(-8))

5. The obtained results indicate that the changes in gene expression in bone marrow progenitor cells can be involved into space flight-induced osteopenia.

6. COL15A1, provide evidence for concomitant epigenetic regulation and genetic susceptibility, and define a class of causal targets that sit at the intersection of genetic and epigenetic predisposition in the etiology of complex disease.

7. These results suggest genetic variation in COL15A1 and COL18A1 can modify the age of onset of both early and late onset POAG.

8. Collagen type XV and osteocalcin expression are highly sensitive markers to extracellular calcium

9. the crystal structure of the trimerization domain of human type XV collagen

10. type XV and XVIII collagens are expressed in specialized basement membranes.

11. Results show that the molecular structure of human tissue type XV presents a unique conformation among the collagens.

12. the primary determinant is the gene specifying collagen XV, a proteoglycan closely associated with the basement membrane

13. Polymorphisms in COL15 (collagen XV) gene are not associated with systemic sclerosis

14. Data represent the first evidence of the expression of collagen type XV in human osteoblasts, a calcium-regulated protein which correlates to a specific functional state of these cells.

Mouse (Murine) Collagen, Type XV, alpha 1 (COL15A1) Interaktionspartner

1. The neuroprotection observed in ColXV KO mice may be attributed to the increased VEGF-A production following stroke in the ischemic territory.

2. loss of Col15a1resulted in marked attenuation rather than exacerbation of lesion pathogenesis

3. Basement membrane zone collagens XV and XVIII mediate leukocyte influx in renal ischemia-reperfusion.

4. Col XV is necessary for extracellular matrix organization in the heart, and for the structure and functions of microvessels. Col XV deficiency leads to a complex cardiac phenotype and predisposes the subject to pathological responses under cardiac stress.

5. Collagen XV thus contributes to peripheral nerve maturation and C-fiber formation

6. collagens XV and XVIII have distinct roles as revealed by double knockout mice